scholarly journals Role of tribochemistry reactions of B4C on tribofilm growth at a PEEK–steel interface in simulated body fluids

RSC Advances ◽  
2021 ◽  
Vol 11 (52) ◽  
pp. 32717-32729
Author(s):  
Gen Liu ◽  
Guitao Li ◽  
Fuyan Zhao ◽  
Nikolai K. Myshkin ◽  
Ga Zhang
Keyword(s):  
Barrier Layer ◽  
Body Fluids ◽  
Corrosion Performance ◽  
Phosphate Ions ◽  
Simulated Body Fluids ◽  
Hydrolysis Of

Hydrolysis of B4C particles triggered by friction and deposition of Ca2+ and phosphate ions dominate formation of the barrier layer. The barrier layer endows the PEEK–metal sliding pair enhanced anti-wear and anti-corrosion performance.

MINERALOGY DRIVEN LEACHING OF URANIUM FROM AIRBORNE DUST IN SIMULATED BODY FLUIDS, AND POSSIBLE HEALTH IMPLICATIONS

2020 ◽  
Author(s):  
Eshani Hettiarachchi ◽  
◽  
Shaylene Paul ◽  
Shaylene Paul ◽  
Milton Das ◽  
...  
Keyword(s):  
Body Fluids ◽  
Airborne Dust ◽  
Health Implications ◽  
Simulated Body Fluids

Appropriate regulation of magnesium on hydroxyapatite crystallization in simulated body fluids

CrystEngComm ◽  
2021 ◽  
Author(s):  
Shuqin Jiang ◽  
Yuanyuan Cao ◽  
Chenxi Zong ◽  
Yuanfeng Pang ◽  
Zhiwen Sun
Keyword(s):  
Body Fluids ◽  
Regulation Effect ◽  
Simulated Body Fluids

The regulation effect of Mg2+ on HAP crystallization is closely related to the adding time of Mg2+. The introduction of Mg2+ in the ACP unstable stage is unable to inhibit HAP crystallization.

scholarly journals Steroid Sulphatase and Its Inhibitors: Past, Present and Future

Molecules ◽  
2021 ◽  
Vol 26 (10) ◽  
pp. 2852
Author(s):  
Paul A. Foster
Keyword(s):  
Good Evidence ◽  
The Past ◽  
Steroid Sulphatase ◽  
University Of Oxford ◽  
Therapeutic Value ◽  
Breast And Prostate Cancer ◽  
The University ◽  
Further Development ◽  
Hydrolysis Of

Steroid sulphatase (STS), involved in the hydrolysis of steroid sulphates, plays an important role in the formation of both active oestrogens and androgens. Since these steroids significantly impact the proliferation of both oestrogen- and androgen-dependent cancers, many research groups over the past 30 years have designed and developed STS inhibitors. One of the main contributors to this field has been Prof. Barry Potter, previously at the University of Bath and now at the University of Oxford. Upon Prof. Potter’s imminent retirement, this review takes a look back at the work on STS inhibitors and their contribution to our understanding of sulphate biology and as potential therapeutic agents in hormone-dependent disease. A number of potent STS inhibitors have now been developed, one of which, Irosustat (STX64, 667Coumate, BN83495), remains the only one to have completed phase I/II clinical trials against numerous indications (breast, prostate, endometrial). These studies have provided new insights into the origins of androgens and oestrogens in women and men. In addition to the therapeutic role of STS inhibition in breast and prostate cancer, there is now good evidence to suggest they may also provide benefits in patients with colorectal and ovarian cancer, and in treating endometriosis. To explore the potential of STS inhibitors further, a number of second- and third-generation inhibitors have been developed, together with single molecules that possess aromatase–STS inhibitory properties. The further development of potent STS inhibitors will allow their potential therapeutic value to be explored in a variety of hormone-dependent cancers and possibly other non-oncological conditions.

scholarly journals Regulation of the synthesis and hydrolysis of ATP by mitochondrial ATPase. Role of Mg2+.

1983 ◽  
Vol 258 (22) ◽  
pp. 13673-13679 ◽  
Author(s):  
A Gómez-Puyou ◽  
G Ayala ◽  
U Muller ◽  
M Tuena de Gómez-Puyou
Keyword(s):  
Mitochondrial Atpase ◽  
Hydrolysis Of

The role of pretreatment in improving the enzymatic hydrolysis of lignocellulosic materials

2016 ◽  
Vol 199 ◽  
pp. 49-58 ◽  
Author(s):  
Shaoni Sun ◽  
Shaolong Sun ◽  
Xuefei Cao ◽  
Runcang Sun
Keyword(s):  
Enzymatic Hydrolysis ◽  
Lignocellulosic Materials ◽  
Hydrolysis Of

scholarly journals “Newton’s cradle” proton relay with amide–imidic acid tautomerization in inverting cellulase visualized by neutron crystallography

2015 ◽  
Vol 1 (7) ◽  
pp. e1500263 ◽  
Author(s):  
Akihiko Nakamura ◽  
Takuya Ishida ◽  
Katsuhiro Kusaka ◽  
Taro Yamada ◽  
Shinya Fushinobu ◽  
...  
Keyword(s):  
Glycoside Hydrolases ◽  
Side Chain ◽  
Enzymatic Reactions ◽  
X Ray Diffraction ◽  
Peptide Bonds ◽  
Proton Relay ◽  
Newton’S Cradle ◽  
Dynamics Simulations ◽  
Hydrolysis Of

Hydrolysis of carbohydrates is a major bioreaction in nature, catalyzed by glycoside hydrolases (GHs). We used neutron diffraction and high-resolution x-ray diffraction analyses to investigate the hydrogen bond network in inverting cellulase PcCel45A, which is an endoglucanase belonging to subfamily C of GH family 45, isolated from the basidiomycete Phanerochaete chrysosporium. Examination of the enzyme and enzyme-ligand structures indicates a key role of multiple tautomerizations of asparagine residues and peptide bonds, which are finally connected to the other catalytic residue via typical side-chain hydrogen bonds, in forming the “Newton’s cradle”–like proton relay pathway of the catalytic cycle. Amide–imidic acid tautomerization of asparagine has not been taken into account in recent molecular dynamics simulations of not only cellulases but also general enzyme catalysis, and it may be necessary to reconsider our interpretation of many enzymatic reactions.

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