scholarly journals Consecutive reactions to construct tricarbonyl compounds and synthetic applications thereof

RSC Advances ◽  
2021 ◽  
Vol 11 (53) ◽  
pp. 33235-33244
Author(s):  
Diego Madroñero ◽  
Cesar A. Mujica-Martinez ◽  
Alfredo Vázquez
Keyword(s):  
Cascade Process ◽  
Condensation Reactions ◽  
Consecutive Reactions ◽  
Intramolecular Condensation ◽  
Acid Esters

A cascade process to construct synthetically valuable β-keto-β′-acylcycloalkanecarboxylic acid esters and their transformation into bicyclic and tricyclic systems through intramolecular condensation reactions.

scholarly journals One-Pot Synthesis of Novel Multisubstituted 1-Alkoxyindoles

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1466
Author(s):  
Ye Eun Kim ◽  
Hyunsung Cho ◽  
Yoo Jin Lim ◽  
Chorong Kim ◽  
Sang Hyup Lee
Keyword(s):  
Alkyl Halide ◽  
The Novel ◽  
Reaction Conditions ◽  
One Pot ◽  
One Pot Synthesis ◽  
Consecutive Reactions ◽  
Intramolecular Condensation ◽  
Synthetic Sequence ◽  
Novel Target

Studies on a one-pot synthesis of novel multisubstituted 1-alkoxyindoles 1 and their mechanistic investigations are presented. The synthesis of 1 was successfully achieved through consecutive four step reactions from substrates 2. The substrates 2, prepared through a two-step synthetic sequence, underwent three consecutive reactions of nitro reduction, intramolecular condensation, and nucleophilic 1,5-addition to provide the intermediates, 1-hydroxyindoles 8, which then were alkylated in situ with alkyl halide to afford the novel target products 1. We optimized the reaction conditions for 1 focusing on the alkylation step, along with the consideration of formation of intermediates 8. The optimized condition was SnCl2·2H2O (3.3 eq) and alcohols (R1OH, 2.0 eq) for 1–2 h at 40 °C and then, base (10 eq) and alkyl halides (R2Y, 2.0 eq) for 1–4 h at 25–50 °C. Notably, all four step reactions were performed in one-pot to give 1 in good to modest yields. Furthermore, the mechanistic aspects were also discussed regarding the reaction pathways and the formation of side products. The significance lies in development of efficient one-pot reactions and in generation of new 1-alkoxyindoles.

Selectivity Analysis for Networks Comprising Consecutive Reactions of Second and First Order

2018 ◽  
Vol 17 (5) ◽  
Author(s):  
Dmitry Yu. Murzin ◽  
Irina L. Simakova ◽  
Johan Wärnå
Keyword(s):  
Cascade Process ◽  
Reaction Parameters ◽  
One Pot ◽  
First Order ◽  
Consecutive Reactions

Abstract Coupling of second and first order reactions in one pot fashion through a cascade process is an often encountered process. Consecutive reactions of this type are considered and selectivity analysis is performed demonstrating dependence of selectivity pattern on reaction parameters.

Intramolecular Condensation Reactions of α, ω-BIS(Triethoxysilyl) Alkanes. Formation of Cyclic disilsesquioxanes

1996 ◽  
Vol 435 ◽  
Author(s):  
Douglas A. Loy ◽  
Joseph P. Carpenter ◽  
Sharon A. Myers ◽  
Roger A. Assink ◽  
James H. Small ◽  
...  
Keyword(s):  
Condensation Reactions ◽  
Intramolecular Condensation

Hydrolytische Bildung von Perchlorsiloxanen / Formation of Chlorosiloxanes by Hydrolysis

1999 ◽  
Vol 54 (5) ◽  
pp. 577-582 ◽  
Author(s):  
Heike Quellhorst ◽  
Andreas Wilkening ◽  
Nicola Söger ◽  
Michael Binnewies
Keyword(s):  
Mass Spectrometry ◽  
Gas Phase ◽  
Reactive Intermediates ◽  
Reaction Products ◽  
Condensation Reactions ◽  
Intramolecular Condensation ◽  
Hydrolysis Reactions

During the reaction of Si2OCl6 with H2O in the gas phase the intermediate Si2OCl5OH has been observed by mass-spectrometry. Reactive intermediates like this are responsible for the formation of higher chlorosilanes by slow hydrolysis reactions of chlorosilanes and -siloxanes. Reaction products of inter- and intramolecular condensation reactions have been observed by GC-MS-methods.

Click reactions and intramolecular condensation reactions on azido-adamantyl-functionalized tin sulfide clusters

2019 ◽  
Vol 6 (8) ◽  
pp. 1973-1976 ◽  
Author(s):  
Annikka Engel ◽  
Eike Dornsiepen ◽  
Stefanie Dehnen
Keyword(s):  
Tin Sulfide ◽  
Click Reactions ◽  
Condensation Reactions ◽  
Intramolecular Condensation ◽  
Sulfide Clusters

Azide–alkyl decorated organotin sulfide clusters were synthesized and further reacted to form peptide-decorated derivatives in solution via strain-promoted azide–alkyne cycloaddition as the key step.

Intramolecular Condensation Reactions of S-Methylmethionine Coordinated to Cobalt(III)

1994 ◽  
Vol 47 (3) ◽  
pp. 501 ◽  
Author(s):  
PM Angus ◽  
BT Golding ◽  
SS Jurisson ◽  
AM Sargeson ◽  
AC Willis
Keyword(s):  
Crystallographic Analysis ◽  
Monoclinic Space Group ◽  
Sulfonium Salt ◽  
Space Group ◽  
X Ray ◽  
Condensation Reactions ◽  
Aqueous Base ◽  
Intramolecular Condensation ◽  
R Factors

The sulfonium salt [(en)2CoO2CCH(NH2)(CH2)2S(CH3)2]3+ (en = ethane-1,2-diamine), prepared by methylation of the thioether group of N,O-coordinated methionine , undergoes a set of complex, intramolecular condensations, oxidations, and rearrangements in aqueous base to give a novel pentadentate cobalt(III) complex (c. 20%) of the 1,9-diamino-4-hydroxy-3,7-diazanonane-4-carboxylate ion ( dhnc ). Its structure has been determined by X-ray crystallographic analysis as trans(O,O)-[Co( dhnc )(OH2)](ClO4)2.2H2O. The crystals were monoclinic, space group P 21/c with a 9.053(2), b 29.437(7), c 7.661(1) Ǻ, β 106.63(1)°, and Z 4; 2383 data with I ≥ 3σ(I) were refined to conventional R factors of 0.046 and 0.060. Investigations concerning the mechanism for the formation of this complex are described.

scholarly journals Intramolecular condensation reactions in protonated dipeptides: Carbon monoxide, water, and ammonia losses in competition

2004 ◽  
Vol 15 (7) ◽  
pp. 1025-1038 ◽  
Author(s):  
Francesco Pingitore ◽  
Michael J. Polce ◽  
Ping Wang ◽  
Chrys Wesdemiotis ◽  
Béla Paizs
Keyword(s):  
Carbon Monoxide ◽  
Condensation Reactions ◽  
Intramolecular Condensation
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