scholarly journals Microwave-assisted green construction of imidazole-fused hybrid scaffolds using 2-aminobenzimidazoles as building blocks

RSC Advances ◽  
2021 ◽  
Vol 11 (35) ◽  
pp. 21367-21374
Author(s):  
Jung Pyo Kwak ◽  
Pham Duy Quang Dao ◽  
Nam Sik Yoon ◽  
Chan Sik Cho
Keyword(s):  
Transition Metal ◽  
Microwave Irradiation ◽  
Green Synthesis ◽  
Building Blocks ◽  
Metal Free ◽  
Microwave Assisted ◽  
Green Construction ◽  
Hybrid Scaffolds

A green synthesis of trinuclear imidazole-fused hybrid scaffolds has been developed by transition metal-free double C(sp2)–N coupling and cyclization of 2-(2-bromoaryl)- and 2-(2-bromovinyl)imidazoles with 2-aminobenzimidazoles as building blocks under microwave irradiation.

Transition metal-free construction of trinuclear N-fused hybrid scaffolds by double nucleophilic aromatic substitution under microwave irradiation

2019 ◽  
Vol 21 (24) ◽  
pp. 6590-6593 ◽  
Author(s):  
Pham Duy Quang Dao ◽  
Ho-Jin Lim ◽  
Chan Sik Cho
Keyword(s):  
Transition Metal ◽  
Microwave Irradiation ◽  
Nucleophilic Aromatic Substitution ◽  
Aromatic Substitution ◽  
Metal Free ◽  
Green Construction ◽  
Free Construction ◽  
Hybrid Scaffolds

A green construction of trinuclear N-fused hybrid scaffolds by transition metal-free double C(sp2)–N coupling of 2-(2-bromoaryl)- and 2-(2-bromovinyl)benzimidazoles with 2-aminoazoles under microwave irradiation has been developed.

scholarly journals Empowering Transition-Metal-Free Cascade Protocol for the Green Synthesis of Biaryls and Alkynes

ACS Omega ◽  
2018 ◽  
Vol 3 (2) ◽  
pp. 1983-1990 ◽  
Author(s):  
Preet Kamal Walia ◽  
Manoj Kumar ◽  
Vandana Bhalla
Keyword(s):  
Transition Metal ◽  
Green Synthesis ◽  
Metal Free

scholarly journals Microwave-assisted green synthesis of bile acid derivatives and evaluation of glucocorticoid receptor binding

2020 ◽  
Author(s):  
Bojana R. Vasiljević ◽  
Edward T. Petri ◽  
Sofija S. Bekić ◽  
Andjelka S. Ćelić ◽  
Ljubica M. Grbović ◽  
...  
Keyword(s):  
Bile Acid ◽  
Microwave Irradiation ◽  
Glucocorticoid Receptor ◽  
Ligand Binding ◽  
Green Synthesis ◽  
Bile Acids ◽  
Receptor Binding ◽  
Microwave Assisted ◽  
Bile Acid Derivatives ◽  
Cholanic Acid

Green synthesis of bile acids derivatives and 5β-cholanic acid was achieved under microwave irradiation, and the binding affinity for the ligand binding domain of the glucocorticoid receptor was measured.

Microwave Assisted Synthesis of N-(ethoxycarbonylmethyl)-nucleobases: Building Blocks for PNAs

2005 ◽  
Vol 2005 (3) ◽  
pp. 167-168 ◽  
Author(s):  
Gui-Rong Qu ◽  
Yong Li ◽  
Su-Hui Han
Keyword(s):  
Microwave Irradiation ◽  
Nucleic Acids ◽  
Peptide Nucleic Acids ◽  
Building Blocks ◽  
Microwave Assisted Synthesis ◽  
Ethyl Bromoacetate ◽  
Microwave Assisted

The synthesis of N1/N9- (Ethoxycarbonylmethyl)pyrimidine/purine using as synthons for peptide nucleic acids has been described. Microwave irradiation provided the desired products by alkylation of the appropriately protected natural and substituted nucleobases with ethyl bromoacetate within 4–7 min in 48–85% yields.

Microwave-assisted transition-metal-free intramolecular Ullmann-type O-arylation in water for the synthesis of xanthones and azaxanthones

2014 ◽  
Vol 55 (35) ◽  
pp. 4883-4887 ◽  
Author(s):  
Xiaojin Zhang ◽  
Li Yang ◽  
Yue Wu ◽  
Jianyao Du ◽  
Yingle Mao ◽  
...  
Keyword(s):  
Transition Metal ◽  
Metal Free ◽  
Microwave Assisted

scholarly journals Microwave irradiation: a green approach for the synthesis of functionalizedN-methyl-1,4-dihydropyridines

RSC Advances ◽  
2018 ◽  
Vol 8 (73) ◽  
pp. 41892-41903 ◽  
Author(s):  
M. Musawwer Khan ◽  
Saigal Saigal ◽  
Sarfaraz Khan ◽  
Sumbulunnisan Shareef ◽  
Subash C. Sahoo
Keyword(s):  
Microwave Irradiation ◽  
Green Synthesis ◽  
Microwave Assisted ◽  
Green Approach

Microwave-assisted green synthesis ofN-methyl-1,4-dihydropyridines under eco-friendly conditions.

The highly efficient air oxidation of aryl and alkyl boronic acids by a microwave-assisted protocol under transition metal-free conditions

2019 ◽  
Vol 21 (17) ◽  
pp. 4614-4618 ◽  
Author(s):  
Weiyan Yin ◽  
Xizhi Pan ◽  
Wenxi Leng ◽  
Jian Chen ◽  
Haifeng He
Keyword(s):  
Transition Metal ◽  
Boronic Acids ◽  
Air Oxidation ◽  
Metal Free ◽  
Microwave Assisted ◽  
Highly Efficient

A rapid, green and efficient microwave-assisted protocol is developed for the air oxidation of boronic acids to phenols and alcohols under transition metal-free conditions.

scholarly journals Microwave-assisted, ligand-free, direct C–H arylation of thiophenes in biomass-derived γ-valerolactone

2017 ◽  
Vol 41 (17) ◽  
pp. 9210-9215 ◽  
Author(s):  
Silvia Tabasso ◽  
Emanuela Calcio Gaudino ◽  
Laura Rinaldi ◽  
Audrey Ledoux ◽  
Paolo Larini ◽  
...  
Keyword(s):  
Microwave Irradiation ◽  
Green Synthesis ◽  
Microwave Assisted ◽  
Ligand Free

We report a ligand-free green synthesis of arylthiophenes and poly(3-hexyl)thiophene in GVL under microwave irradiation.

Sonication and Microwave-Assisted Primary Amination of Potassium­ Aryltrifluoroborates and Phenylboronic Acids under Metal-Free Conditions

Synthesis ◽  
2017 ◽  
Vol 49 (11) ◽  
pp. 2555-2561 ◽  
Author(s):  
Dale Kuik ◽  
J. McCubbin ◽  
Geoffrey Tranmer
Keyword(s):  
Transition Metal ◽  
Reaction Times ◽  
Aqueous Sodium Hydroxide ◽  
Metal Free ◽  
Microwave Assisted ◽  
Free Generation ◽  
Phenylboronic Acids ◽  
Microwave Assisted Method ◽  
General Method ◽  
Electron Withdrawing Substituents

The transition-metal-free generation of a series of primary arylamines from potassium aryltrifluoroborates and phenylboronic acids­ is reported. The method uses a mild, inexpensive source of nitrogen (hydroxylamine-O-sulfonic acid) in cooperation with aqueous sodium hydroxide in acetonitrile. Both a sonication and a microwave-assisted method were developed, which are capable of converting ArBF3K functionalities into primary arylamines (ArNH2) in isolated yields of up to 78% (10 examples for each method). This report represents the first general method for the conversion of aryltrifluoroborates into primary arylamines under mild, transition-metal-free conditions in moderate to very good yields. The method is applicable to a wide array of substrates containing electron-donating, electron-neutral, or electron-withdrawing substituents. Both the sonication and microwave methods were also applied to the generation of anilines from phenylboronic acids in isolated yields of up to 96% (12 examples for each method) that were superior to existing room temperature methods in terms of yield, while also offering much shorter reaction times (15 min vs 16 h). In particular, the microwave method is the first to allow for the conversion of arylboronic acids containing strongly electron-withdrawing substituents into the corresponding anilines in good yields, along with electron-donating­ substituents in very good to excellent yields.

Sign in / Sign up

Export Citation Format

Share Document