scholarly journals Microwave irradiation: a green approach for the synthesis of functionalizedN-methyl-1,4-dihydropyridines

RSC Advances ◽  
2018 ◽  
Vol 8 (73) ◽  
pp. 41892-41903 ◽  
Author(s):  
M. Musawwer Khan ◽  
Saigal Saigal ◽  
Sarfaraz Khan ◽  
Sumbulunnisan Shareef ◽  
Subash C. Sahoo
Keyword(s):  
Microwave Irradiation ◽  
Green Synthesis ◽  
Microwave Assisted ◽  
Green Approach

Microwave-assisted green synthesis ofN-methyl-1,4-dihydropyridines under eco-friendly conditions.

Microwave Assisted Synthesis of Schiff Bases: A Green Approach

2012 ◽  
Vol 10 (1) ◽  
Author(s):  
Mousumi Chakraborty ◽  
Sanjay Baweja ◽  
Sunita Bhagat ◽  
TejpalSingh Chundawat
Keyword(s):  
Microwave Irradiation ◽  
Microwave Power ◽  
Mass Spectra ◽  
Molar Ratio ◽  
Microwave Assisted Synthesis ◽  
Schiff’S Bases ◽  
Microwave Assisted ◽  
Green Approach ◽  
Schiff's Bases ◽  
Effects Of Temperature

Abstract In the present study Schiff’s bases are synthesized by the conventional as well as by microwave irradiation. Excellent yield within short reaction time is obtained using microwave irradiation along with other advantages like mild reaction condition, non-hazardous and safer environmental conditions. The effects of temperature, reactant molar ratio, and microwave power variation on yield are observed. Mathematical model has been developed using matlab software to obtain the yield as a function of microwave power. Kinetic study of the reaction has also been attempted. Schiff’s bases structures are confirmed by IR, 1HNMR, Mass Spectra and elemental analysis.

scholarly journals Microwave-assisted green synthesis of bile acid derivatives and evaluation of glucocorticoid receptor binding

2020 ◽  
Author(s):  
Bojana R. Vasiljević ◽  
Edward T. Petri ◽  
Sofija S. Bekić ◽  
Andjelka S. Ćelić ◽  
Ljubica M. Grbović ◽  
...  
Keyword(s):  
Bile Acid ◽  
Microwave Irradiation ◽  
Glucocorticoid Receptor ◽  
Ligand Binding ◽  
Green Synthesis ◽  
Bile Acids ◽  
Receptor Binding ◽  
Microwave Assisted ◽  
Bile Acid Derivatives ◽  
Cholanic Acid

Green synthesis of bile acids derivatives and 5β-cholanic acid was achieved under microwave irradiation, and the binding affinity for the ligand binding domain of the glucocorticoid receptor was measured.

Ultrasonic and microwave assisted extraction as rapid and efficient techniques for plant mediated synthesis of quantum dots: green synthesis, characterization of zinc telluride and comparison study of some biological activities

2019 ◽  
Vol 43 (38) ◽  
pp. 15126-15138 ◽  
Author(s):  
Zinab Moradi Alvand ◽  
Hamid Reza Rajabi ◽  
Ali Mirzaei ◽  
Asad Masoumiasl
Keyword(s):  
Quantum Dots ◽  
Green Synthesis ◽  
Biological Activities ◽  
Zinc Telluride ◽  
Microwave Assisted Extraction ◽  
Comparison Study ◽  
Microwave Assisted ◽  
Green Approach ◽  
Assisted Extraction

In this study, a simple, rapid, and efficient plant-mediated green approach was presented for the synthesis of stable and ultra-small zinc telluride quantum dots (ZnTe QDs) using the aqueous extract of the Ficus johannis plant.

scholarly journals Microwave-assisted, ligand-free, direct C–H arylation of thiophenes in biomass-derived γ-valerolactone

2017 ◽  
Vol 41 (17) ◽  
pp. 9210-9215 ◽  
Author(s):  
Silvia Tabasso ◽  
Emanuela Calcio Gaudino ◽  
Laura Rinaldi ◽  
Audrey Ledoux ◽  
Paolo Larini ◽  
...  
Keyword(s):  
Microwave Irradiation ◽  
Green Synthesis ◽  
Microwave Assisted ◽  
Ligand Free

We report a ligand-free green synthesis of arylthiophenes and poly(3-hexyl)thiophene in GVL under microwave irradiation.

Novel one-pot green synthesis of graphene in aqueous medium under microwave irradiation using a regenerative catalyst and the study of its electrochemical properties

2015 ◽  
Vol 39 (1) ◽  
pp. 420-430 ◽  
Author(s):  
Badrayyana Subramanya ◽  
Denthaje Krishna Bhat
Keyword(s):  
Microwave Irradiation ◽  
Green Synthesis ◽  
Electrochemical Properties ◽  
Aqueous Medium ◽  
High Throughput ◽  
High Performance ◽  
One Pot ◽  
Green Approach

High throughput synthesis of superior quality graphene by a unified green approach for high performance supercapacitors.

scholarly journals Microwave-assisted green construction of imidazole-fused hybrid scaffolds using 2-aminobenzimidazoles as building blocks

RSC Advances ◽  
2021 ◽  
Vol 11 (35) ◽  
pp. 21367-21374
Author(s):  
Jung Pyo Kwak ◽  
Pham Duy Quang Dao ◽  
Nam Sik Yoon ◽  
Chan Sik Cho
Keyword(s):  
Transition Metal ◽  
Microwave Irradiation ◽  
Green Synthesis ◽  
Building Blocks ◽  
Metal Free ◽  
Microwave Assisted ◽  
Green Construction ◽  
Hybrid Scaffolds

A green synthesis of trinuclear imidazole-fused hybrid scaffolds has been developed by transition metal-free double C(sp2)–N coupling and cyclization of 2-(2-bromoaryl)- and 2-(2-bromovinyl)imidazoles with 2-aminobenzimidazoles as building blocks under microwave irradiation.

Regioselective Synthesis of Potent 4,5,6,7-Tetrahydroindazole Derivatives via Microwave-assisted Vilsmeier-Haack Reaction and their Antioxidant Activity Evaluation

2019 ◽  
Vol 16 (3) ◽  
pp. 194-201 ◽  
Author(s):  
Renu Bala ◽  
Vandana Devi ◽  
Pratibha Singh ◽  
Navjot Kaur ◽  
Pawandeep Kaur ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Microwave Irradiation ◽  
Biological Activities ◽  
Reaction Times ◽  
Conventional Heating ◽  
High Chemical ◽  
Microwave Assisted ◽  
Work Up ◽  
Active Methylene ◽  
By Products

Background: Tetrahydroindazole, a member of the fused-pyrazole system, is a least studied class of heterocyclic compounds owing to its scarcity in nature. However, a large number of synthetically prepared tetrahydroindazoles are known to show a variety of biological activities such as interleukin- 2 inducible T-Cell kinase inhibitors, AMPA receptor positive allosteric modulators, antitumor, antituberculosis, anti-inflammatory and antimicrobial activities. Vilsmeier-Haack reaction is one of the most important chemical reactions used for formylation of electron rich arenes. Even though Vilsmeier- Haack reaction was studied on a wide variety of hydrazones derived from active methylene compounds, literature lacks the examples of the use of 4-substituted cyclohexanones as a substrate for the synthesis of 4,5,6,7-tetrahydroindazoles. The study of the reaction of Vilsmeier-Haack reagent with hydrazones derived from cyclic keto compounds having active methylene has been considered the interested topic of investigation. In the present study, ethyl cyclohexanone-4-carboxylate was treated with one equivalent of various hydrazines for two hours and the resulted hydrazones were further treated with an OPC-VH reagent (Vilsmeier-Haack reagent isolated from phthaloyl dichloride and N,Ndimethylformamide) afforded 4,5,6,7-tetrahydroindazoles in excellent yields. The synthesized compounds 4a-f and 5a-f were screened for their antioxidant activities using the DPPH radical scavenging assay. The target compounds were synthesized regioselectively using 4+1 approach in excellent yields. A number of experiments using both conventional heating as well as microwave irradiation methods were tried and on comparison, microwave irradiation method was found excellent in terms of easy work up, high chemical yields, shortened reaction times, clean and, no by-products formation. Some of the synthesized compounds showed significant antioxidant activity. The microwave assisted synthesis of 4,5,6,7-tetrahydroindazoles from ethyl cyclohexanone-4-carboxylate has been reported under mild conditions in excellent yield. Easy work up, high chemical yield, shortened reaction times, clean and no by-products formation are the major advantages of this protocol. These advantages may make this method useful for chemists who are interested in developing novel 4,5,6,7-tetrahydroindazole based drugs.

Microwave-assisted Synthesis of Benzoxazoles Derivatives

2020 ◽  
Vol 7 (3) ◽  
pp. 183-195
Author(s):  
Musa Özil ◽  
Emre Menteşe
Keyword(s):  
Microwave Irradiation ◽  
Reaction Medium ◽  
Pharmaceutical Chemistry ◽  
Conventional Heating ◽  
High Yield ◽  
Microwave Assisted Synthesis ◽  
Microwave Assisted ◽  
Optical Brighteners ◽  
Chemistry Research ◽  
Extensive Class

Background: Benzoxazole, containing a 1,3-oxazole system fused with a benzene ring, has a profound effect on medicinal chemistry research owing to its important pharmacological activities. On the other hand, the benzoxazole derivative has exhibited important properties in material science. Especially in recent years, microwave-assisted synthesis is a technique that can be used to increase diversity and quick research in modern chemistry. The utilization of microwave irradiation is beneficial for the synthesis of benzoxazole in recent years. In this focused review, we provide a metaanalysis of studies on benzoxazole in different reaction conditions, catalysts, and starting materials by microwave technique so far, which is different from conventional heating. Methods: Synthesis of different kind of benzoxazole derivatives have been carried out by microwave irradiation. The most used method to obtain benzoxazoles is the condensation of 2-aminophenol or its derivatives with aldehydes, carboxylic acids, nitriles, isocyanates, and aliphatic amines. Results: Benzoxazole system and its derivatives have exhibited a broad range of pharmacological properties. Thus, many scientists have remarked on the importance of the synthesis of different benzoxazole derivatives. Conventional heating is a relatively inefficient and slow method to convey energy in orientation to the reaction medium. However, the microwave-assisted heating technique is a more effective interior heating by straight coupling of microwave energy with the molecules. Conclusion: In this review, different studies were presented on the recent details accessible in the microwave- assisted techniques on the synthesis of the benzoxazole ring. It presents all examples of such compounds that have been reported from 1996 to the present. Benzoxazoles showed an extensive class of chemical substances not only in pharmaceutical chemistry but also in dyestuff, polymer industries, agrochemical, and optical brighteners. Thus the development of fast and efficient achievement of benzoxazoles with a diversity of substituents in high yield is getting more noteworthy. As shown in this review, microwave-assisted synthesis of benzoxazoles is a very effective and useful technique.

Sign in / Sign up

Export Citation Format

Share Document