scholarly journals Antioxidant defense system responses, lysosomal membrane stability and DNA damage in earthworms (Eisenia fetida) exposed to perfluorooctanoic acid: an integrated biomarker approach to evaluating toxicity

RSC Advances ◽  
2021 ◽  
Vol 11 (43) ◽  
pp. 26481-26492
Author(s):  
Zhifeng Wang ◽  
Chaona Li ◽  
Yuanyuan Shao ◽  
Weina Xue ◽  
Ning Wang ◽  
...  
Keyword(s):  
Dna Damage ◽  
Eisenia Fetida ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Lysosomal Membrane ◽  
Defense System ◽  
Integrated Biomarker Response ◽  
Toxicological Effects ◽  
Biomarker Response ◽  
Lysosomal Membrane Stability

The integrated biomarker response (IBR) index was calculated to evaluate the integrated toxicological effects of PFOA on earthworm Eisenia fetida.

Toxicological effects of pyraclostrobin on the antioxidant defense system and DNA damage in earthworms (Eisenia fetida)

2019 ◽  
Vol 101 ◽  
pp. 111-116 ◽  
Author(s):  
Junchao Ma ◽  
Chao Cheng ◽  
Zhongkun Du ◽  
Bing Li ◽  
Jinhua Wang ◽  
...  
Keyword(s):  
Dna Damage ◽  
Eisenia Fetida ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Defense System ◽  
Toxicological Effects

Increased oxidative DNA damage and impaired antioxidant defense system in patients with gastrointestinal cancer

2012 ◽  
Vol 23 (4) ◽  
pp. 350-354 ◽  
Author(s):  
Aymelek Gönenç ◽  
Aysun Hacışevki ◽  
Sabahattin Aslan ◽  
Meral Torun ◽  
Bolkan Şimşek
Keyword(s):  
Dna Damage ◽  
Gastrointestinal Cancer ◽  
Oxidative Dna Damage ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Defense System

A Case-Control Study of Involvement of Oxidative DNA Damage and Alteration of Antioxidant Defense System in Patients with Basal Cell Carcinoma: Effect of Tumor Removal

2015 ◽  
Vol 87 ◽  
pp. S70
Author(s):  
Uraiwan Panich ◽  
Lapatsanant Chaisiriwong Chaisiriwong ◽  
Rungsima Wanitphakdeedecha ◽  
Panitta Sitthinamsuwan ◽  
Somruedee Chatsiricharoenkul ◽  
...  
Keyword(s):  
Dna Damage ◽  
Basal Cell Carcinoma ◽  
Oxidative Dna Damage ◽  
Antioxidant Defense ◽  
Case Control Study ◽  
Antioxidant Defense System ◽  
Case Control ◽  
Defense System ◽  
Tumor Removal ◽  
Control Study

Toxicological effects of bisphenol A on growth and antioxidant defense system in Oryza sativa as revealed by ultrastructure analysis

2016 ◽  
Vol 124 ◽  
pp. 277-284 ◽  
Author(s):  
Imran Ali ◽  
Bohan Liu ◽  
Muhammad Ahsan Farooq ◽  
Faisal Islam ◽  
Azizullah Azizullah ◽  
...  
Keyword(s):  
Oryza Sativa ◽  
Bisphenol A ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Defense System ◽  
Toxicological Effects

scholarly journals Behavioural, Histopathological, Genetic and Organism-Wide Responses to Phenanthrene-Induced Oxidative Stress in Eisenia Fetida Earthworms in Natural Soil Microcosms

2021 ◽  
Author(s):  
Falin He ◽  
Hanmei Yu ◽  
Huijian Shi ◽  
Xiangxiang Li ◽  
Shanshan Chu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Oxidative Damage ◽  
Eisenia Fetida ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Natural Soil ◽  
High Dose ◽  
Soil Environment ◽  
Defense System ◽  
Toxicity Potential

Abstract Phenanthrene (PHE) contamination not only changes the quality of soil environment but also threatens to the soil organisms. There is lack of focus on the eco-toxicity potential of contaminants in real soil in the current investigation. Here, we assessed the toxic effects of PHE on earthworms (Eisenia fetida) in natural soil matrix. PHE exhibited a relatively high toxicity to E. fetida in natural soil, with the LC50 determined to be 56.68 mg kg−1 after a 14-day exposure. Excessive ROS induced by PHE, leading to oxidative damage to biomacromolecules in E. fetida, including lipid peroxidation, protein carbonylation, and DNA damage. The antioxidant defense system (total antioxidant capacity, glutathione S-transferase, peroxidase, catalase, carboxylesterase, and superoxide dismutase) in E. fetida responded quickly to scavenge excess ROS and free radicals. Exposure to PHE resulted in earthworm avoidance responses (2.5 mg kg−1) and habitat function loss (10 mg kg−1). Histological observations indicated that the intestine, body wall, and seminal vesicle in E. fetida were severely damaged after exposure to high-dose PHE. Moreover, earthworm growth (weight change) and reproduction (cocoon production and the number of juvenile) were also inhibited after exposure to this pollutant. Furthermore, the integrated toxicity of PHE toward E. fetida at different doses and exposure times was assessed by the integrated biomarker response (IBR), which confirm that PHE is more toxic to earthworms in the high-dose and long-term exposure groups. Our results showed that PHE exposure induced oxidative stress, disturbed antioxidant defense system, and caused oxidative damage in E. fetida. These effects can trigger behavior changes and damaged histological structure, finally cause growth inhibition, genotoxicity, and reproductive toxicity in earthworms. The strength of this study is the comprehensive toxicity evaluation of PHE to earthworms and highlights the need to investigate the t eco-toxicity potential of exogenous environmental pollutants in a real soil environment.

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