The changes of antioxidant defense system caused by quercetin administration do not lead to DNA damage and apoptosis in the spleen and bone marrow cells of rats

2008 ◽  
Vol 46 (9) ◽  
pp. 3053-3058 ◽  
Author(s):  
M.A. Papiez ◽  
A. Cierniak ◽  
W. Krzysciak ◽  
M. Bzowska ◽  
H.M. Taha ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Dna Damage ◽  
Antioxidant Defense ◽  
Bone Marrow Cells ◽  
Antioxidant Defense System ◽  
Defense System ◽  
Marrow Cells

scholarly journals Friend Leukemia Virus Infection Enhances DNA Damage-Induced Apoptosis of Hematopoietic Cells, Causing Lethal Anemia in C3H Hosts

2002 ◽  
Vol 76 (15) ◽  
pp. 7790-7798 ◽  
Author(s):  
Masanobu Kitagawa ◽  
Shuichi Yamaguchi ◽  
Maki Hasegawa ◽  
Kaoru Tanaka ◽  
Toshihiko Sado ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Dna Damage ◽  
Knockout Mice ◽  
Bone Marrow Cells ◽  
Leukemia Virus ◽  
Hematopoietic Cells ◽  
Friend Leukemia ◽  
C3h Mice ◽  
Friend Leukemia Virus ◽  
Marrow Cells

ABSTRACT Exposure of hematopoietic progenitors to gamma irradiation induces p53-dependent apoptosis. However, host responses to DNA damage are not uniform and can be modified by various factors. Here, we report that a split low-dose total-body irradiation (TBI) (1.5 Gy twice) to the host causes prominent apoptosis in bone marrow cells of Friend leukemia virus (FLV)-infected C3H mice but not in those of FLV-infected DBA mice. In C3H mice, the apoptosis occurs rapidly and progressively in erythroid cells, leading to lethal host anemia, although treatment with FLV alone or TBI alone induced minimal apoptosis in bone marrow cells. A marked accumulation of P53 protein was demonstrated in bone marrow cells from FLV-infected C3H mice 12 h after treatment with TBI. Although a similar accumulation of P53 was also observed in bone marrow cells from FLV-infected DBA mice treated with TBI, the amount appeared to be parallel to that of mice treated with TBI alone and was much lower than that of FLV- plus TBI-treated C3H mice. To determine the association of p53 with the prominent enhancement of apoptosis in FLV- plus TBI-treated C3H mice, p53 knockout mice of the C3H background (C3H p53−/− ) were infected with FLV and treated with TBI. As expected, p53 knockout mice exhibited a very low frequency of apoptosis in the bone marrow after treatment with FLV plus TBI. Further, C3H p53−/− → C3H p53+/+ bone marrow chimeric mice treated with FLV plus TBI survived even longer than the chimeras treated with FLV alone. These findings indicate that infection with FLV strongly enhances radiation-induced apoptotic cell death of hematopoietic cells in host animals and that the apoptosis occurs through a p53-associated signaling pathway, although the response was not uniform in different host strains.

An oxovanadium(IV) complex protects murine bone marrow cells against cisplatin-induced myelotoxicity and DNA damage

2016 ◽  
Vol 40 (3) ◽  
pp. 359-367 ◽  
Author(s):  
Abhishek Basu ◽  
Arin Bhattacharjee ◽  
Amalesh Samanta ◽  
Sudin Bhattacharya
Keyword(s):  
Bone Marrow ◽  
Dna Damage ◽  
Bone Marrow Cells ◽  
Murine Bone Marrow ◽  
Marrow Cells

Increased oxidative DNA damage and impaired antioxidant defense system in patients with gastrointestinal cancer

2012 ◽  
Vol 23 (4) ◽  
pp. 350-354 ◽  
Author(s):  
Aymelek Gönenç ◽  
Aysun Hacışevki ◽  
Sabahattin Aslan ◽  
Meral Torun ◽  
Bolkan Şimşek
Keyword(s):  
Dna Damage ◽  
Gastrointestinal Cancer ◽  
Oxidative Dna Damage ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Defense System

Prolonged Quercetin Administration Diminishes the Etoposide-Induced DNA Damage in Bone Marrow Cells of Rats

2007 ◽  
Vol 30 (1) ◽  
pp. 67-81 ◽  
Author(s):  
Maria Kapiszewska ◽  
Agnieszka Cierniak ◽  
Monika A. Papiez ◽  
Agata Pietrzycka ◽  
Marek Stepniewski ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Dna Damage ◽  
Bone Marrow Cells ◽  
Marrow Cells

Pendimethalin induces oxidative stress, DNA damage, and mitochondrial dysfunction to trigger apoptosis in human lymphocytes and rat bone-marrow cells

2017 ◽  
Vol 149 (2) ◽  
pp. 127-141 ◽  
Author(s):  
Sabiha M. Ansari ◽  
Quaiser Saquib ◽  
Sabry M. Attia ◽  
Eslam M. Abdel-Salam ◽  
Hend A. Alwathnani ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Bone Marrow ◽  
Dna Damage ◽  
Mitochondrial Dysfunction ◽  
Bone Marrow Cells ◽  
Human Lymphocytes ◽  
Rat Bone ◽  
Marrow Cells

scholarly journals Antioxidant defense system responses, lysosomal membrane stability and DNA damage in earthworms (Eisenia fetida) exposed to perfluorooctanoic acid: an integrated biomarker approach to evaluating toxicity

RSC Advances ◽  
2021 ◽  
Vol 11 (43) ◽  
pp. 26481-26492
Author(s):  
Zhifeng Wang ◽  
Chaona Li ◽  
Yuanyuan Shao ◽  
Weina Xue ◽  
Ning Wang ◽  
...  
Keyword(s):  
Dna Damage ◽  
Eisenia Fetida ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Lysosomal Membrane ◽  
Defense System ◽  
Integrated Biomarker Response ◽  
Toxicological Effects ◽  
Biomarker Response ◽  
Lysosomal Membrane Stability

The integrated biomarker response (IBR) index was calculated to evaluate the integrated toxicological effects of PFOA on earthworm Eisenia fetida.

A Case-Control Study of Involvement of Oxidative DNA Damage and Alteration of Antioxidant Defense System in Patients with Basal Cell Carcinoma: Effect of Tumor Removal

2015 ◽  
Vol 87 ◽  
pp. S70
Author(s):  
Uraiwan Panich ◽  
Lapatsanant Chaisiriwong Chaisiriwong ◽  
Rungsima Wanitphakdeedecha ◽  
Panitta Sitthinamsuwan ◽  
Somruedee Chatsiricharoenkul ◽  
...  
Keyword(s):  
Dna Damage ◽  
Basal Cell Carcinoma ◽  
Oxidative Dna Damage ◽  
Antioxidant Defense ◽  
Case Control Study ◽  
Antioxidant Defense System ◽  
Case Control ◽  
Defense System ◽  
Tumor Removal ◽  
Control Study
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