Current progress, challenges and future prospects of indazoles as protein kinase inhibitors for the treatment of cancer

Nitin Tandon; Vijay Luxami; Divya Kant; Runjhun Tandon; Kamaldeep Paul

doi:10.1039/d1ra03979b

Current progress, challenges and future prospects of indazoles as protein kinase inhibitors for the treatment of cancer

RSC Advances ◽

10.1039/d1ra03979b ◽

2021 ◽

Vol 11 (41) ◽

pp. 25228-25257

Author(s):

Nitin Tandon ◽

Vijay Luxami ◽

Divya Kant ◽

Runjhun Tandon ◽

Kamaldeep Paul

Keyword(s):

Protein Kinase ◽

Medicinal Chemistry ◽

Kinase Inhibitors ◽

Protein Kinase Inhibitors ◽

Future Prospects

The indazole core is an interesting pharmacophore due to its applications in medicinal chemistry.

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ChemInform Abstract: Biologically Driven Synthesis of Pyrazolo[3,4-d]pyrimidines as Protein Kinase Inhibitors: An Old Scaffold as a New Tool for Medicinal Chemistry and Chemical Biology Studies

ChemInform ◽

10.1002/chin.201440235 ◽

2014 ◽

Vol 45 (40) ◽

pp. no-no

Author(s):

Silvia Schenone ◽

Marco Radi ◽

Francesca Musumeci ◽

Chiara Brullo ◽

Maurizio Botta

Keyword(s):

Protein Kinase ◽

Chemical Biology ◽

Medicinal Chemistry ◽

Kinase Inhibitors ◽

Protein Kinase Inhibitors

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Discovery of a New Class of Synthetic Protein Kinase Inhibitors that Suppress Selective Aspects of Glial Activation and Protect Against β-Amyloid Induced Injury: A Foundation for Future Medicinal Chemistry Efforts Focused on Targeting Alzheimer's Disease Progression

Journal of Molecular Neuroscience ◽

10.1385/jmn:20:3:411 ◽

2003 ◽

Vol 20 (3) ◽

pp. 411-424 ◽

Cited By ~ 6

Author(s):

D. Martin Watterson ◽

Anastasia V. Velentza ◽

Magdalena Zasadzki ◽

Jeffrey M. Craft ◽

Jacques Haiech ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Protein Kinase ◽

Disease Progression ◽

Medicinal Chemistry ◽

Kinase Inhibitors ◽

Protein Kinase Inhibitors ◽

Glial Activation ◽

New Class ◽

Synthetic Protein ◽

Β Amyloid

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Biologically Driven Synthesis of Pyrazolo[3,4-d]pyrimidines As Protein Kinase Inhibitors: An Old Scaffold As a New Tool for Medicinal Chemistry and Chemical Biology Studies

Chemical Reviews ◽

10.1021/cr400270z ◽

2014 ◽

Vol 114 (14) ◽

pp. 7189-7238 ◽

Cited By ~ 67

Author(s):

Silvia Schenone ◽

Marco Radi ◽

Francesca Musumeci ◽

Chiara Brullo ◽

Maurizio Botta

Keyword(s):

Protein Kinase ◽

Chemical Biology ◽

Medicinal Chemistry ◽

Kinase Inhibitors ◽

Protein Kinase Inhibitors

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Editorial [Hot Topic: Protein Kinase Inhibitors: Current Strategies and Future Prospects (Executive Guest Editor: Julio Caballero)]

Current Pharmaceutical Design ◽

10.2174/138161212800672769 ◽

2012 ◽

Vol 18 (20) ◽

pp. 2851-2851

Author(s):

Julio Caballero

Keyword(s):

Protein Kinase ◽

Guest Editor ◽

Kinase Inhibitors ◽

Protein Kinase Inhibitors ◽

Future Prospects

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Faculty Opinions recommendation of Re-positioning protein-kinase inhibitors against schistosomiasis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725849707.793510456 ◽

2015 ◽

Author(s):

William Evan Secor

Keyword(s):

Protein Kinase ◽

Kinase Inhibitors ◽

Protein Kinase Inhibitors

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In silico Modeling of Antimalarial Protein Kinase Inhibitors

Letters in Drug Design & Discovery ◽

10.2174/1570180812666150723000621 ◽

2015 ◽

Vol 13 (2) ◽

pp. 129-134 ◽

Cited By ~ 1

Author(s):

Rahul Balasaheb Aher ◽

Kunal Roy

Keyword(s):

Protein Kinase ◽

In Silico ◽

Kinase Inhibitors ◽

Protein Kinase Inhibitors ◽

In Silico Modeling

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Thiazolidine-diones. Biochemical and biological activity of a novel class of tyrosine protein kinase inhibitors.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)45697-9 ◽

1990 ◽

Vol 265 (36) ◽

pp. 22255-22261

Author(s):

J F Geissler ◽

P Traxler ◽

U Regenass ◽

B J Murray ◽

J L Roesel ◽

...

Keyword(s):

Biological Activity ◽

Protein Kinase ◽

Kinase Inhibitors ◽

Protein Kinase Inhibitors ◽

Tyrosine Protein Kinase

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Protein kinase inhibitors for the treatment of prostate cancer

Expert Opinion on Pharmacotherapy ◽

10.1080/14656566.2021.1925250 ◽

2021 ◽

pp. 1-11

Author(s):

Vincent Chau ◽

Ravi A. Madan ◽

Jeanny B. Aragon-Ching

Keyword(s):

Prostate Cancer ◽

Protein Kinase ◽

Kinase Inhibitors ◽

Protein Kinase Inhibitors

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Astrocyte morphology altered by 1-(5-isoquinolinylsulfonyl) 2-methyl piperazine (H-7) and other protein kinase inhibitors

Brain Research ◽

10.1016/0006-8993(89)90242-4 ◽

1989 ◽

Vol 490 (2) ◽

pp. 243-254 ◽

Cited By ~ 16

Author(s):

Cynthia A. Bedoy ◽

Philip L. Mobley

Keyword(s):

Protein Kinase ◽

Kinase Inhibitors ◽

Protein Kinase Inhibitors

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Molecular hybrids: A five-year survey on structures of multiple targeted hybrids of protein kinase inhibitors for cancer therapy

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2021.113768 ◽

2021 ◽

pp. 113768

Author(s):

Osama M. Soltan ◽

Mai E. Shoman ◽

Salah A. Abdel-Aziz ◽

Atsushi Narumi ◽

Hiroyuki Konno ◽

...

Keyword(s):

Protein Kinase ◽

Cancer Therapy ◽

Kinase Inhibitors ◽

Protein Kinase Inhibitors ◽

Molecular Hybrids

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