scholarly journals Active targeting of cancer cells by CD44 binding peptide-functionalized oil core-based nanocapsules

RSC Advances ◽  
2021 ◽  
Vol 11 (40) ◽  
pp. 24487-24499
Author(s):  
A. De Capua ◽  
A. Palladino ◽  
M. Chino ◽  
C. Attanasio ◽  
A. Lombardi ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Multilayer Shell ◽  
Active Targeting ◽  
Binding Peptide ◽  
Biological Tests ◽  
Core Polymer

CD44 binding peptide was implemented onto an oil core–polymer multilayer shell of 100 nm size and completely biodegradable. Biological tests, demonstrated that the proposed nanocarrier selectively accumulates and internalizes in cancer cells.

scholarly journals Comparison Direct Synthesis of Hyaluronic Acid-Based Carbon Nanodots as Dual Active Targeting and Imaging of HeLa Cancer Cells

ACS Omega ◽  
2021 ◽  
Author(s):  
Yu-Yu Aung ◽  
Aswandi Wibrianto ◽  
Jefry S. Sianturi ◽  
Desita K. Ulfa ◽  
Satya. C. W. Sakti ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cancer Cells ◽  
Direct Synthesis ◽  
Active Targeting ◽  
Carbon Nanodots

scholarly journals Identification of the sAPRIL Binding Peptide and Its Growth Inhibition Effects in the Colorectal Cancer Cells

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0120564 ◽  
Author(s):  
Xiao-qing He ◽  
Jing Guan ◽  
Fang Liu ◽  
Jing Li ◽  
Mei-rong He
Keyword(s):  
Colorectal Cancer ◽  
Growth Inhibition ◽  
Cancer Cells ◽  
Binding Peptide ◽  
Colorectal Cancer Cells

scholarly journals Anti-ROR1 functionalised PLGA nanoparticles modulate metastatic and EMT biomarkers via cellular uptake of curcumin and ICA in colon cancer cells SW480

2020 ◽  
Author(s):  
Shamim Sufi ◽  
Muddasarul Hoda ◽  
Sankar Pajaniradje ◽  
Victor Mukherjee ◽  
Sultana Parveen ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Cellular Uptake ◽  
Isothermal Calorimetry ◽  
Cell Surface Receptor ◽  
In Vivo Studies ◽  
Active Targeting ◽  
Colon Cancer Cells ◽  
Mesenchymal Transition ◽  
Surface Functionalisation

The challenge of next-generation nanoparticles (NPs) includes limited cellular uptake and loss by phagocytosis. General surface modification of NPs potentially enhances evasion from phagocytosis. However, active targeting and enhanced cellular uptake of nanoparticles are possible by surface functionalisation with molecules that have selective affinity for cancer cells. ROR1 is a cell surface receptor that is over-expressed in cancer cells. Hence, its conjugate antibody could be a potential surface functionalisation molecule. In the current study, anti-ROR1 antibody has been covalently attached to nanoparticles’ surface, thereby imparting its active targeting potential. Physicochemical and in vitro characterisations of the antibody-conjugated nanoparticles were performed. Surface functionalisation of nanoparticles was confirmed by scanning electron microscopy, isothermal calorimetry, and elemental analysis. Additionally, biomarkers of metastasis and epithelial-mesenchymal transition (EMT) were studied. Anti-ROR1 mAb tagged nanoparticles further confirmed therapeutic efficacy against colon cancer cells, SW480, thus, opening scope for further in vivo studies.

Gene Delivery with Active Targeting to Ovarian Cancer Cells Mediated by Folate Receptor α

2013 ◽  
Vol 9 (5) ◽  
pp. 833-844 ◽  
Author(s):  
Zhiyao He ◽  
Yiyi Yu ◽  
Ying Zhang ◽  
Yongdong Yan ◽  
Yu Zheng ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Gene Delivery ◽  
Cancer Cells ◽  
Folate Receptor ◽  
Active Targeting ◽  
Ovarian Cancer Cells

Active targeting nano-scale bubbles enhanced ultrasound cavitation chemotherapy in Y1 receptor-overexpressed breast cancer

2020 ◽  
Vol 8 (31) ◽  
pp. 6837-6844
Author(s):  
Xuechen Qian ◽  
Yinjie Wang ◽  
Youfeng Xu ◽  
Ling Ma ◽  
Nianyu Xue ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Cancer Cells ◽  
Therapeutic Efficacy ◽  
Breast Cancer Cells ◽  
Ultrasound Irradiation ◽  
Active Targeting ◽  
Receptor Ligand ◽  
Y1 Receptor ◽  
Nano Scale

Y1 receptor ligand-modified nanobubbles could target breast cancer cells and improve therapeutic efficacy with reduced side effects under ultrasound irradiation during chemotherapy.

scholarly journals Does conjugation strategy matter? Cetuximab-conjugated gold nanocages for targeting triple-negative breast cancer cells

2019 ◽  
Vol 1 (9) ◽  
pp. 3626-3638 ◽  
Author(s):  
S. Avvakumova ◽  
L. Pandolfi ◽  
E. Soprano ◽  
L. Moretto ◽  
M. Bellini ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Active Targeting ◽  
Gold Nanocages

The efficient targeting of cancer cells depends on the success of obtaining the active targeting of overexpressed receptors.

scholarly journals MCP mediated active targeting calcium phosphate hybrid nanoparticles for the treatment of orthotopic drug-resistant colon cancer

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Shaobo Bai ◽  
Yang Sun ◽  
Ying Cheng ◽  
Weiliang Ye ◽  
Chenchao Jiang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Calcium Phosphate ◽  
Protein Expression ◽  
Cancer Cells ◽  
Active Targeting ◽  
Cancer Targeting ◽  
Drug Resistant ◽  
Colon Cancer Cells ◽  
Apoptosis Pathway ◽  
Calcium Phosphate Nanoparticles

Abstract Background Colon cancer is a most common malignant cancer in digestive system, and it is prone to develop resistance to the commonly used chemotherapy drugs, leading to local recurrence and metastasis. Paris saponin VII (PSVII) could not only inhibit the proliferation of colon cancer cells but also effectively induce apoptosis of drug-resistant colon cancer cells and reduce the metastasis of drug-resistant colon cancer cells as well. However, PSVII was insoluble in water and fat. It displayed no selective distribution in body and could cause severe hemolysis. Herein, colon cancer targeting calcium phosphate nanoparticles were developed to carry PSVII to treat drug-resistant colon cancer. Results PSVII carboxymethyl-β-cyclodextrin inclusion compound was successfully encapsulated in colon cancer targeting calcium phosphate nanoparticles (PSVII@MCP-CaP) by using modified citrus pectin as stabilizer agent and colon cancer cell targeting moiety. PSVII@MCP-CaP significantly reduced the hemolysis of PSVII. Moreover, by specific accumulating in orthotopic drug-resistant colon cancer tissue, PSVII@MCP-CaP markedly inhibited the growth of orthotopic drug-resistant colon cancer in nude mice. PSVII@MCP-CaP promoted the apoptosis of drug-resistant colon cancer cells through mitochondria-mediated apoptosis pathway. Moreover, PSVII@MCP-CaP significantly inhibited the invasion and migration of drug-resistant colon cancer cells by increasing E-cadherin protein expression and reducing N-cadherin and MMP-9 protein expression. Conclusion PSVII@MCP-CaP has great potential in the treatment of drug-resistant colon cancer. This study also explores a new method to prepare active targeting calcium phosphate nanoparticles loaded with a fat and water insoluble compound in water. Graphical Abstract

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