scholarly journals Novel potentiometric sensors for determination of ondansetron hydrochloride in pure and dosage form

RSC Advances ◽  
2021 ◽  
Vol 11 (55) ◽  
pp. 34820-34827
Author(s):  
Amina M. Abass ◽  
Sahar S. M. Alabdullah ◽  
Omar Salih Hassan ◽  
Ahmed Ahmed
Keyword(s):  
Dosage Form ◽  
Potentiometric Method ◽  
Potentiometric Sensors ◽  
Ondansetron Hydrochloride

A new and sensitive potentiometric method has been developed and characterized for four novel sensors responsive to ondansetron hydrochloride.

scholarly journals New potentiometric sensors for methylphenidate detection based on host–guest interaction

BMC Chemistry ◽  
2019 ◽  
Vol 13 (1) ◽  
Author(s):  
Haitham AlRabiah ◽  
Mohammed Abounassif ◽  
Haya I. Aljohar ◽  
Gamal Abdel-Hafiz Mostafa
Keyword(s):  
Dosage Form ◽  
Fast Response ◽  
High Accuracy ◽  
Hplc Method ◽  
Dioctyl Phthalate ◽  
Potentiometric Sensors ◽  
Routine Laboratory ◽  
Electroactive Materials ◽  
Ph Range

Abstract The study aims to develop simple, sensitive, and selective methods for detecting methylphenidate in its bulk, dosage form and human urine. Sensing materials include β-cyclodextrin (β-CD), γ-cyclodextrin (γ-CD), and 4-tertbutylcalix[8]arene as ionophores or electroactive materials have been used for construction of sensors 1, 2, and 3, respectively; Potassium tetrakis (4-chlorophenyl)borate (KTpClPB) as an ion additive was used and dioctyl phthalate as a plasticizer. The sensors displayed a fast, stable response over a wide concentration range of methylphenidate (8 × 10−6 M to 1 × 10−3 M) with 10−6 M detection limit over the pH range of 4–8. The developed sensors displayed a Near-Nernstian cationic response for methylphenidate at 59.5, 51.37, and 56.5 mV/decade for sensors β-CD, γ-CD, or 4-tertbutylcalix[8]arene respectively. Validation of the proposed sensors is supported by high accuracy, precision, stability, fast response, and long lifetimes, as well as selectivity for methylphenidate in the presence of different species. Sensitive and practical sensors for the determination of methylphenidate in bulk, in pharmaceutical forms and urine were developed and validated for routine laboratory use. The results were comparable to those obtained by HPLC method.

High-performance thin-layer chromatographic determination of rosiglitazone in its dosage form

2002 ◽  
Vol 15 (3) ◽  
pp. 192-195 ◽  
Author(s):  
Ramesh Sane ◽  
Mary Francis ◽  
Atul Moghe ◽  
Sachin Khedkar ◽  
Ajit Anerao
Keyword(s):  
Thin Layer ◽  
High Performance ◽  
Dosage Form ◽  
Chromatographic Determination
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