scholarly journals RAFT polymerization mediated core–shell supramolecular assembly of PEGMA-co-stearic acid block co-polymer for efficient anticancer drug delivery

RSC Advances ◽  
2021 ◽  
Vol 11 (28) ◽  
pp. 16913-16923
Author(s):  
Priyatosh Sarkar ◽  
Santanu Ghosh ◽  
Rima Saha ◽  
Kishor Sarkar
Keyword(s):  
Drug Delivery ◽  
Stearic Acid ◽  
Anticancer Drug ◽  
Chain Transfer ◽  
Raft Polymerization ◽  
Supramolecular Assembly ◽  
Core Shell ◽  
Anticancer Drug Delivery ◽  
Reversible Addition

In this work, core–shell supramolecular assembly polymeric nano-architectures containing hydrophilic and hydrophobic segments were synthesized via reversible addition fragmentation chain transfer (RAFT) polymerization.

Core–shell tecto dendrimers formed via host–guest supramolecular assembly as pH-responsive intelligent carriers for enhanced anticancer drug delivery

Nanoscale ◽  
2019 ◽  
Vol 11 (46) ◽  
pp. 22343-22350 ◽  
Author(s):  
Jianhong Wang ◽  
Du Li ◽  
Yu Fan ◽  
Menghan Shi ◽  
Yunxia Yang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Supramolecular Assembly ◽  
Anticancer Therapy ◽  
Ph Sensitive ◽  
Core Shell ◽  
Ph Responsive ◽  
Anticancer Drug Delivery

Core–shell tecto dendrimers can be prepared via host–guest supramolecular assembly for encapsulation and pH-sensitive release of drugs for an improved anticancer therapy.

scholarly journals Functional Magnetic Core-Shell System-Based Iron Oxide Nanoparticle Coated with Biocompatible Copolymer for Anticancer Drug Delivery

Pharmaceutics ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 120 ◽  
Author(s):  
Thai Hoang Thi ◽  
Diem-Huong Nguyen Tran ◽  
Long Bach ◽  
Hieu Vu-Quang ◽  
Duy Nguyen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Anticancer Drug ◽  
Targeted Delivery ◽  
Superparamagnetic Iron Oxide ◽  
Proton Nuclear Magnetic Resonance ◽  
Iron Oxide Nanoparticle ◽  
Core Shell ◽  
Anticancer Drug Delivery ◽  
Shell System

Polymer coating has drawn increasing attention as a leading strategy to overcome the drawbacks of superparamagnetic iron oxide nanoparticles (SPIONs) in targeted delivery of anticancer drugs. In this study, SPIONs were modified with heparin-Poloxamer (HP) shell to form a SPION@HP core-shell system for anticancer drug delivery. The obtained formulation was characterized by techniques including transmission electron microscopy (TEM), Fourier transform infrared spectra (FT-IR), vibration sample magnetometer (VSM), proton nuclear magnetic resonance (1H-NMR), and powder X-ray diffraction (XRD). Results showed the successful attachment of HP shell on the surface of SPION core and the inability to cause considerable effects to the crystal structure and unique magnetic nature of SPION. The core-shell system maintains the morphological features of SPIONs and the desired size range. Notably, Doxorubicin (DOX), an anticancer drug, was effectively entrapped into the polymeric shell of SPION@HP, showing a loading efficiency of 66.9 ± 2.7% and controlled release up to 120 h without any initial burst effect. Additionally, MTT assay revealed that DOX-loaded SPION@HP exerted great anticancer effect against HeLa cells and could be safely used. These results pave the way for the application of SPION@HP as an effective targeted delivery system for cancer treatment.

Poly(N-isopropylacrylamide)-b-Poly(L-lysine)-b-Poly(L-histidine) Triblock Amphiphilic Copolymer Nanomicelles for Dual-Responsive Anticancer Drug Delivery

2020 ◽  
Vol 20 (11) ◽  
pp. 6959-6967
Author(s):  
Rimesh Augustine ◽  
Dae-Kyoung Kim ◽  
Ho An Kim ◽  
Jae Ho Kim ◽  
Il Kim
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Drug Loading ◽  
Anticancer Drug Delivery ◽  
Dual Responsive ◽  
Micellar Aggregates ◽  
Reversible Addition ◽  
Hydrogen Carbonate ◽  
Copolymer Micelle

A series of ABC triblock poly(N-isopropylacrylamide)75-block-poly(L-lysine)35-block-poly(L-histidine)n (p(NIPAM)75-b-p(Lys)35-b-p(His)N) (N = 35,50,75,100) copolymer bio-conjugates were prepared by combining reversible addition-fragmentation chain transfer polymerization and fast ring-opening polymerization of N-carboxyanhydride a-amino acid using 1,3-dicyclohexylimidazolium hydrogen carbonate as a catalyst. All the resulting triblock copolymers self-assembled into spherical micellar aggregates in aqueous solution, irrespective of the chain length of the histidine block. The micellar aggregates encapsulated the anticancer drug doxorubicin (Dox) and exhibited high drug loading efficiency. Temperature and pH stimuli were applied to investigate the controlled release of Dox. The non-cytotoxic nature of the polymers was investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Cellular uptake of the Dox-loaded micelles revealed that the micelles successfully release Dox in cancer cells in response to pH- and temperature-induced morphological change. In-vitro studies further confirmed that the Dox-loaded triblock copolymer micelle is an excellent platform for drug delivery.

Multifunctional Core-Shell-Corona-Type Polymeric Micelles for Anticancer Drug-Delivery and Imaging

2013 ◽  
Vol 19 (15) ◽  
pp. 4812-4817 ◽  
Author(s):  
Bishnu Prasad Bastakoti ◽  
Kevin C.-W. Wu ◽  
Masamichi Inoue ◽  
Shin-ichi Yusa ◽  
Kenichi Nakashima ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Polymeric Micelles ◽  
Core Shell ◽  
Anticancer Drug Delivery

Synthesis of Polylactide-Based Core-Shell Interface Cross-Linked Micelles for Anticancer Drug Delivery

2016 ◽  
Vol 17 (3) ◽  
pp. 1600191 ◽  
Author(s):  
Chih-Kuang Chen ◽  
Wei-Jen Lin ◽  
Yu Hsia ◽  
Leu-Wei Lo
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Core Shell ◽  
Anticancer Drug Delivery
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