Synthesis of Polylactide-Based Core-Shell Interface Cross-Linked Micelles for Anticancer Drug Delivery

2016 ◽  
Vol 17 (3) ◽  
pp. 1600191 ◽  
Author(s):  
Chih-Kuang Chen ◽  
Wei-Jen Lin ◽  
Yu Hsia ◽  
Leu-Wei Lo
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Core Shell ◽  
Anticancer Drug Delivery

scholarly journals Functional Magnetic Core-Shell System-Based Iron Oxide Nanoparticle Coated with Biocompatible Copolymer for Anticancer Drug Delivery

Pharmaceutics ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 120 ◽  
Author(s):  
Thai Hoang Thi ◽  
Diem-Huong Nguyen Tran ◽  
Long Bach ◽  
Hieu Vu-Quang ◽  
Duy Nguyen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Anticancer Drug ◽  
Targeted Delivery ◽  
Superparamagnetic Iron Oxide ◽  
Proton Nuclear Magnetic Resonance ◽  
Iron Oxide Nanoparticle ◽  
Core Shell ◽  
Anticancer Drug Delivery ◽  
Shell System

Polymer coating has drawn increasing attention as a leading strategy to overcome the drawbacks of superparamagnetic iron oxide nanoparticles (SPIONs) in targeted delivery of anticancer drugs. In this study, SPIONs were modified with heparin-Poloxamer (HP) shell to form a SPION@HP core-shell system for anticancer drug delivery. The obtained formulation was characterized by techniques including transmission electron microscopy (TEM), Fourier transform infrared spectra (FT-IR), vibration sample magnetometer (VSM), proton nuclear magnetic resonance (1H-NMR), and powder X-ray diffraction (XRD). Results showed the successful attachment of HP shell on the surface of SPION core and the inability to cause considerable effects to the crystal structure and unique magnetic nature of SPION. The core-shell system maintains the morphological features of SPIONs and the desired size range. Notably, Doxorubicin (DOX), an anticancer drug, was effectively entrapped into the polymeric shell of SPION@HP, showing a loading efficiency of 66.9 ± 2.7% and controlled release up to 120 h without any initial burst effect. Additionally, MTT assay revealed that DOX-loaded SPION@HP exerted great anticancer effect against HeLa cells and could be safely used. These results pave the way for the application of SPION@HP as an effective targeted delivery system for cancer treatment.

Multifunctional Core-Shell-Corona-Type Polymeric Micelles for Anticancer Drug-Delivery and Imaging

2013 ◽  
Vol 19 (15) ◽  
pp. 4812-4817 ◽  
Author(s):  
Bishnu Prasad Bastakoti ◽  
Kevin C.-W. Wu ◽  
Masamichi Inoue ◽  
Shin-ichi Yusa ◽  
Kenichi Nakashima ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Polymeric Micelles ◽  
Core Shell ◽  
Anticancer Drug Delivery

Hydrogen Sulfide-Activatable Prodrug-Backboned Block Copolymer Micelles for Delivery of Chemotherapeutics

2021 ◽  
Author(s):  
Jiajia Xiang ◽  
Peiwen Xing ◽  
Liu Xin ◽  
Peihong Shen ◽  
Shiqun Shao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hydrogen Sulfide ◽  
Block Copolymer ◽  
Anticancer Drug ◽  
Amphiphilic Block Copolymer ◽  
Core Shell ◽  
Anticancer Drug Delivery ◽  
Block Copolymer Micelles ◽  
Stable Core ◽  
Copolymer Micelles

Amphiphilic block copolymer prodrugs, which can self-assemble into stable core-shell micelles, have been widely used for anticancer drug delivery. However, a major challenge remains to design drug-conjugating linkers stable in...

Core/shell structured hollow mesoporous sSiO2@mSiO2 nanocapsules for anticancer drug delivery

2017 ◽  
Vol 182 (1) ◽  
pp. 134-138 ◽  
Author(s):  
Liang He ◽  
Yi-Fan Wang ◽  
Bing Yu ◽  
Hai-Lin Cong ◽  
Kai-Li Yuan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Core Shell ◽  
Anticancer Drug Delivery

Core/Shell Structured Hollow Mesoporous Nanocapsules: A Potential Platform for Simultaneous Cell Imaging and Anticancer Drug Delivery

ACS Nano ◽  
2010 ◽  
Vol 4 (10) ◽  
pp. 6001-6013 ◽  
Author(s):  
Yu Chen ◽  
Hangrong Chen ◽  
Deping Zeng ◽  
Yunbo Tian ◽  
Feng Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Cell Imaging ◽  
Core Shell ◽  
Anticancer Drug Delivery
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