scholarly journals A reduction-responsive drug delivery with improved stability: disulfide crosslinked micelles of small amiphiphilic molecules

RSC Advances ◽  
2021 ◽  
Vol 11 (21) ◽  
pp. 12757-12770
Author(s):  
Man Li ◽  
Longbing Ling ◽  
Qing Xia ◽  
Xinsong Li
Keyword(s):  
Drug Delivery ◽  
Triggered Release ◽  
Improved Stability ◽  
Crosslinked Micelles

Reduction-responsive crosslinked di-LA-PC micelles from amphiphilic bis-LA-PC conjugate for PTX loading and GSH-triggered release of PTX.

pH-Triggered release of gemcitabine from polymer coated nanodiamonds fabricated by RAFT polymerization and copper free click chemistry

2016 ◽  
Vol 7 (40) ◽  
pp. 6220-6230 ◽  
Author(s):  
Haiwang Lai ◽  
Mingxia Lu ◽  
Hongxu Lu ◽  
Martina H. Stenzel ◽  
Pu Xiao
Keyword(s):  
Drug Delivery ◽  
Pancreatic Cancer ◽  
Click Chemistry ◽  
Raft Polymerization ◽  
Stimuli Responsive ◽  
Triggered Release

Prodrug (gemcitabine)-based polymer coated nanodiamonds as stimuli-responsive drug delivery platforms for the treatment of pancreatic cancer.

Photo-triggered release of 5-fluorouracil from a MOF drug delivery vehicle

2018 ◽  
Vol 54 (55) ◽  
pp. 7617-7620 ◽  
Author(s):  
Kristina Roth Stefaniak ◽  
Charity C. Epley ◽  
Joshua J. Novak ◽  
Margaret L. McAndrew ◽  
Hannah D. Cornell ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Small Molecules ◽  
Metal Organic Framework ◽  
Delivery Vehicle ◽  
Triggered Release ◽  
Drug Delivery Vehicle ◽  
Metal Organic ◽  
Organic Framework

A nano metal–organic-framework (nanoMOF) was employed as a first-of-its kind drug delivery vehicle (DDV) for the photo-controlled release of therapeutics with simultaneous breakdown of the carrier into small molecules.

scholarly journals Hyperthermia and Temperature-Sensitive Nanomaterials for Spatiotemporal Drug Delivery to Solid Tumors

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1007
Author(s):  
Mohamadreza Amin ◽  
Wenqiu Huang ◽  
Ann L. B. Seynhaeve ◽  
Timo L. M. ten Hagen
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Cellular Level ◽  
Advanced Technology ◽  
Temperature Sensitive ◽  
Triggered Release ◽  
Adjuvant Effect ◽  
Triggered Drug Release ◽  
High Level ◽  
External Stimuli

Nanotechnology has great capability in formulation, reduction of side effects, and enhancing pharmacokinetics of chemotherapeutics by designing stable or long circulating nano-carriers. However, effective drug delivery at the cellular level by means of such carriers is still unsatisfactory. One promising approach is using spatiotemporal drug release by means of nanoparticles with the capacity for content release triggered by internal or external stimuli. Among different stimuli, interests for application of external heat, hyperthermia, is growing. Advanced technology, ease of application and most importantly high level of control over applied heat, and as a result triggered release, and the adjuvant effect of hyperthermia in enhancing therapeutic response of chemotherapeutics, i.e., thermochemotherapy, make hyperthermia a great stimulus for triggered drug release. Therefore, a variety of temperature sensitive nano-carriers, lipid or/and polymeric based, have been fabricated and studied. Importantly, in order to achieve an efficient therapeutic outcome, and taking the advantages of thermochemotherapy into consideration, release characteristics from nano-carriers should fit with applicable clinical thermal setting. Here we introduce and discuss the application of the three most studied temperature sensitive nanoparticles with emphasis on release behavior and its importance regarding applicability and therapeutic potentials.

Redox Sensitive Polysaccharide Based Nanoparticles for Improved Cancer Treatment: A Comprehensive Review

2018 ◽  
Vol 24 (28) ◽  
pp. 3303-3319 ◽  
Author(s):  
Erfaneh Ghassami ◽  
Jaleh Varshosaz ◽  
Somayeh Taymouri
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Drug Delivery Systems ◽  
Chemical Properties ◽  
Delivery Systems ◽  
Exchange Reactions ◽  
Triggered Release ◽  
Redox Responsive

Background: Among the numerous bio-responsive polymeric drug delivery systems developed recently, redox-triggered release of molecular payloads have gained great deal of attention, especially in the field of anticancer drug delivery. In most cases, these systems rely on disulfide bonds located either in the matrix crosslinks, or in auxiliary chains to achieve stimuli-responsive drug release. These bonds keep their stability in extracellular environments, yet, rapidly break by thiol–disulfide exchange reactions in the cytosol, due to the presence of greater levels of glutathione. Polysaccharides are macromolecules with low cost, natural abundance, biocompatibility, biodegradability, appropriate physical and chemical properties, and presence of numerous functional groups which facilitate chemical or physical cross-linking. Methods: With regards to the remarkable advantages of polysaccharides, in the current study, various polysaccharide-based redox-responsive drug delivery systems are reviewed. In most cases the in vitro/in vivo effects of the developed system were also evaluated. Results: Considering the hypoxic and reducing nature of the tumor microenvironment, with several folds higher glutathione levels than the systemic tissues, redox-sensitive polymeric systems could be implemented for tumorspecific drug delivery and the results of the previous researches in this field indicated satisfactory achievements. Conclusion: According to the reviewed papers, the efficiency of diverse redox-responsive polysaccharide-based nanoparticles with therapeutic payloads in cancer chemotherapy could be concluded. Nevertheless, more comprehensive studies are required to understand the exact intracellular and systemic fate of these nano-carriers, as well as their clinical efficacy for cancer treatment.

Triggered-release polymeric conjugate micelles for on-demand intracellular drug delivery

2015 ◽  
Vol 26 (11) ◽  
pp. 115101 ◽  
Author(s):  
Yanwu Cao ◽  
Min Gao ◽  
Chao Chen ◽  
Aiping Fan ◽  
Ju Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Triggered Release ◽  
On Demand ◽  
Intracellular Drug Delivery ◽  
Polymeric Conjugate

pH-Sensitive, N-ethoxybenzylimidazole (NEBI) bifunctional crosslinkers enable triggered release of therapeutics from drug delivery carriers

2010 ◽  
Vol 8 (22) ◽  
pp. 5105 ◽  
Author(s):  
Alice Luong ◽  
Tawny Issarapanichkit ◽  
Seong Deok Kong ◽  
Rina Fong ◽  
Jerry Yang
Keyword(s):  
Drug Delivery ◽  
Ph Sensitive ◽  
Triggered Release
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