Synthesis of Indolo[2,1-α]isoquinoline Derivatives via Metal-free Radical Cascade Cyclization

2021 ◽  
Author(s):  
Jianzhong Chen ◽  
Hu Xu-yang ◽  
Haifeng Xu ◽  
Qiang Chen ◽  
You-lu Pan
Keyword(s):  
Free Radical ◽  
Core Structure ◽  
Metal Free ◽  
Cascade Cyclization ◽  
Radical Cascade ◽  
Isoquinoline Derivatives

In the present studies, we described a convenient and efficient protocol for the synthesis of the indolo[2,1-]isoquinoline core structure through the reaction of 2-aryl-N-acryloyl indoles and aryl or alkyl -keto...

Synthesis of indolo[2,1-a]isoquinoline derivatives via visible-light-induced radical cascade cyclization reactions

2019 ◽  
Vol 55 (42) ◽  
pp. 5922-5925 ◽  
Author(s):  
Yun-Long Wei ◽  
Jian-Qiang Chen ◽  
Bo Sun ◽  
Peng-Fei Xu
Keyword(s):  
Visible Light ◽  
Core Structure ◽  
Cyclization Reactions ◽  
Cascade Cyclization ◽  
Radical Cascade ◽  
Isoquinoline Derivatives

We describe a photocatalyzed transformation for the synthesis of the indolo[2,1-a]isoquinoline core structure.

A metal-free radical cascade reaction of phosphine oxides with 2-aryloxy phenylacetylenes to assemble diphosphonyl xanthene derivatives

2021 ◽  
Author(s):  
Tao Fan ◽  
Yan Liu ◽  
Caina Jiang ◽  
Yanli Xu ◽  
Yan-Yan Chen
Keyword(s):  
Free Radical ◽  
Transition Metal ◽  
Cascade Reaction ◽  
Phosphine Oxides ◽  
Metal Free ◽  
Mild Conditions ◽  
Xanthene Derivatives ◽  
Reaction Proceeds ◽  
Radical Cascade

A radical cascade reaction of 2-aryloxy phenylacetylene with phosphine oxides promoted by K2S2O8 was developed, provided diphosphonyl xanthenes as products. This reaction proceeds under transition metal-free and mild conditions with...

Metal-Free Cascade Methylation/Cyclization of N-Alkyl-N-methacryloylbenzamides with Dicumyl Peroxide

Synlett ◽  
2017 ◽  
Vol 29 (05) ◽  
pp. 617-620 ◽  
Author(s):  
Yan-Ning Niu ◽  
Xiao-Feng Xia ◽  
Yuan Yuan
Keyword(s):  
Free Radical ◽  
Dicumyl Peroxide ◽  
Metal Free ◽  
Wide Range ◽  
Radical Cascade ◽  
Convenient Access

A metal-free radical cascade methylation/cyclization of a wide range of N-alkyl-N-methacryloylbenzamides by using dicumyl peroxide as the methylating reagent provides a convenient access to a series of methylated isoquinoline-1,3-diones in moderate yields.

Metal-free radical cascade dichloromethylation of activated alkenes using CH2Cl2: highly selective activation of the C–H bond

RSC Advances ◽  
2014 ◽  
Vol 4 (110) ◽  
pp. 64855-64859 ◽  
Author(s):  
Yunfei Tian ◽  
Zhong-Quan Liu
Keyword(s):  
Free Radical ◽  
Dicumyl Peroxide ◽  
Cascade Process ◽  
Selective Activation ◽  
Metal Free ◽  
Efficient Access ◽  
Radical Cascade

A dicumyl peroxide-initiated highly selective activation of the (sp3)C–H bond in dichloromethane (DCM, CH2Cl2) has been achieved, which allows efficient access to dichloronated oxindoles via a free-radical cascade process.

ChemInform Abstract: A Free Radical Cascade Cyclization of Isocyanides with Simple Alkanes and Alcohols.

ChemInform ◽  
2014 ◽  
Vol 45 (50) ◽  
pp. no-no
Author(s):  
Zejiang Li ◽  
Fenghua Fan ◽  
Jie Yang ◽  
Zhong-Quan Liu
Keyword(s):  
Free Radical ◽  
Cascade Cyclization ◽  
Radical Cascade

Aerobic radical-cascade cycloaddition of isocyanides, selenium and imidamides: facile access to 1,2,4-selenadiazoles under metal-free conditions

2017 ◽  
Vol 19 (7) ◽  
pp. 1613-1618 ◽  
Author(s):  
Yi Fang ◽  
Zheng-Lin Zhu ◽  
Pei Xu ◽  
Shun-Yi Wang ◽  
Shun-Jun Ji
Keyword(s):  
Metal Free ◽  
Cascade Cyclization ◽  
Radical Cascade ◽  
Novel Method

A facile and novel method for the synthesis of functionalized 1,2,4-selenadiazoles through aerobic radical-cascade cyclization of isocyanides, selenium and imidamides is established.

scholarly journals Metal-free synthesis of 1,N6-ethenoadenines from N6-propargyl-adenines via NIS mediated radical cascade reaction

RSC Advances ◽  
2019 ◽  
Vol 9 (66) ◽  
pp. 38897-38901
Author(s):  
Ruchun Yang ◽  
Si Deng ◽  
Xiang-you Dong ◽  
Xianrong Song ◽  
Hu Cai ◽  
...  
Keyword(s):  
Cascade Reaction ◽  
Metal Free ◽  
Efficient Approach ◽  
Cascade Cyclization ◽  
Radical Cascade

An efficient approach for the construction of 1,N6-ethenoadenines is developed through the metal-free mediated radical cascade cyclization of conveniently prepared N6-propargyl-adenines.

Metal-free radical cascade chloromethylation of unactivated alkenes: synthesis of polychloro-substituted indolines

2018 ◽  
Vol 16 (32) ◽  
pp. 5752-5755 ◽  
Author(s):  
Changduo Pan ◽  
Du Gao ◽  
Zhenkun Yang ◽  
Chao Wu ◽  
Jin-Tao Yu
Keyword(s):  
Free Radical ◽  
Metal Free ◽  
Radical Cascade

The di- and trichloromethylation of N-allyl anilines with CH2Cl2, CHCl3 and CCl4 was developed, leading to di- and trichloromethylated indolines.

Facile synthesis of carbamoylated benzimidazo[2,1-a]isoquinolin-6(5H)-ones via radical cascade cyclization under metal-free conditions

2021 ◽  
Author(s):  
Qi Liu ◽  
Lei Wang ◽  
Jie Liu ◽  
Shuchen Ruan ◽  
Pinhua Li
Keyword(s):  
Efficient Synthesis ◽  
Facile Synthesis ◽  
Metal Free ◽  
Cascade Cyclization ◽  
Highly Efficient ◽  
Radical Cascade

A highly efficient synthesis of carbamoylated benzimidazo[2,1-a]isoquinolin-6(5H)-ones using 2-arylbenzoimidazoles and oxamic acids was developed. This strategy tolerated various substrates on the starting materials to generate the corresponding products in good...

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