ChemInform Abstract: A Free Radical Cascade Cyclization of Isocyanides with Simple Alkanes and Alcohols.

ChemInform ◽  
2014 ◽  
Vol 45 (50) ◽  
pp. no-no
Author(s):  
Zejiang Li ◽  
Fenghua Fan ◽  
Jie Yang ◽  
Zhong-Quan Liu
Keyword(s):  
Free Radical ◽  
Cascade Cyclization ◽  
Radical Cascade

A Free Radical Cascade Cyclization of Isocyanides with Simple Alkanes and Alcohols

2014 ◽  
Vol 16 (12) ◽  
pp. 3396-3399 ◽  
Author(s):  
Zejiang Li ◽  
Fenghua Fan ◽  
Jie Yang ◽  
Zhong-Quan Liu
Keyword(s):  
Free Radical ◽  
Cascade Cyclization ◽  
Radical Cascade

Synthesis of Indolo[2,1-α]isoquinoline Derivatives via Metal-free Radical Cascade Cyclization

2021 ◽  
Author(s):  
Jianzhong Chen ◽  
Hu Xu-yang ◽  
Haifeng Xu ◽  
Qiang Chen ◽  
You-lu Pan
Keyword(s):  
Free Radical ◽  
Core Structure ◽  
Metal Free ◽  
Cascade Cyclization ◽  
Radical Cascade ◽  
Isoquinoline Derivatives

In the present studies, we described a convenient and efficient protocol for the synthesis of the indolo[2,1-]isoquinoline core structure through the reaction of 2-aryl-N-acryloyl indoles and aryl or alkyl -keto...

Fe-Catalyzed Conjunctive Cross-Couplings of Unactivated Alkenes with Grignard Reagents

2020 ◽  
Author(s):  
Lei Liu ◽  
Wes Lee ◽  
Cassandra R. Youshaw ◽  
Mingbin Yuan ◽  
Michael B. Geherty ◽  
...  
Keyword(s):  
Functional Groups ◽  
Cross Coupling ◽  
Alkyl Halides ◽  
Grignard Reagents ◽  
Turnover Frequency ◽  
Diverse Range ◽  
Cascade Cyclization ◽  
Radical Cascade

The first iron-catalyzed three-component cross-coupling of unactivated olefins with alkyl halides and Grignard reagents is reported. The reaction operates under fast turnover frequency and tolerates a diverse range of sp2-hybridized nucleophiles, alkyl halides, and unactivated olefins bearing diverse functional groups to yield the desired 1,2-alkylarylated products with high regiocontrol. Further, we demonstrate that this protocol is amenable for the synthesis of new (hetero)carbocycles including tetrahydrofurans and pyrrolidines via a three-component radical cascade cyclization/arylation that forges three new C-C bonds.

A metal-free radical cascade reaction of phosphine oxides with 2-aryloxy phenylacetylenes to assemble diphosphonyl xanthene derivatives

2021 ◽  
Author(s):  
Tao Fan ◽  
Yan Liu ◽  
Caina Jiang ◽  
Yanli Xu ◽  
Yan-Yan Chen
Keyword(s):  
Free Radical ◽  
Transition Metal ◽  
Cascade Reaction ◽  
Phosphine Oxides ◽  
Metal Free ◽  
Mild Conditions ◽  
Xanthene Derivatives ◽  
Reaction Proceeds ◽  
Radical Cascade

A radical cascade reaction of 2-aryloxy phenylacetylene with phosphine oxides promoted by K2S2O8 was developed, provided diphosphonyl xanthenes as products. This reaction proceeds under transition metal-free and mild conditions with...

Metal-Free Cascade Methylation/Cyclization of N-Alkyl-N-methacryloylbenzamides with Dicumyl Peroxide

Synlett ◽  
2017 ◽  
Vol 29 (05) ◽  
pp. 617-620 ◽  
Author(s):  
Yan-Ning Niu ◽  
Xiao-Feng Xia ◽  
Yuan Yuan
Keyword(s):  
Free Radical ◽  
Dicumyl Peroxide ◽  
Metal Free ◽  
Wide Range ◽  
Radical Cascade ◽  
Convenient Access

A metal-free radical cascade methylation/cyclization of a wide range of N-alkyl-N-methacryloylbenzamides by using dicumyl peroxide as the methylating reagent provides a convenient access to a series of methylated isoquinoline-1,3-diones in moderate yields.

Eosin Y photoredox catalyzed net redox neutral reaction for regiospecific annulation to 3-sulfonylindoles via anion oxidation of sodium sulfinate salts

2018 ◽  
Vol 16 (4) ◽  
pp. 536-540 ◽  
Author(s):  
Rajendra S. Rohokale ◽  
Shrikant D. Tambe ◽  
Umesh A. Kshirsagar
Keyword(s):  
Visible Light ◽  
Eosin Y ◽  
Cascade Cyclization ◽  
Neutral Reaction ◽  
Neutral Process ◽  
Radical Cascade

An eosin Y photoredox catalyzed net redox neutral process for 3-sulfonylindoles via the anionic oxidation of sodium sulfinate salts and its radical cascade cyclization with 2-alkynyl-azidoarenes was developed with visible light as a mediator.

Decoding the Complex Free Radical Cascade by Using a DNA Framework‐Based Artificial DNA Encoder

2021 ◽  
Author(s):  
Lili Zhang ◽  
Linlin Wang ◽  
Xi Yuan ◽  
Minjuan Zhong ◽  
Hong Chen ◽  
...  
Keyword(s):  
Free Radical ◽  
Artificial Dna ◽  
Radical Cascade

Metal-free radical cascade dichloromethylation of activated alkenes using CH2Cl2: highly selective activation of the C–H bond

RSC Advances ◽  
2014 ◽  
Vol 4 (110) ◽  
pp. 64855-64859 ◽  
Author(s):  
Yunfei Tian ◽  
Zhong-Quan Liu
Keyword(s):  
Free Radical ◽  
Dicumyl Peroxide ◽  
Cascade Process ◽  
Selective Activation ◽  
Metal Free ◽  
Efficient Access ◽  
Radical Cascade

A dicumyl peroxide-initiated highly selective activation of the (sp3)C–H bond in dichloromethane (DCM, CH2Cl2) has been achieved, which allows efficient access to dichloronated oxindoles via a free-radical cascade process.

Iron-catalyzed radical cascade cyclization of oxime esters with isocyanides: synthesis of 1-cyanoalkyl isoquinolines and 6-cyanoalkyl phenanthridines

2021 ◽  
Vol 19 (39) ◽  
pp. 8597-8606
Author(s):  
Dengqi Xue ◽  
Rongqi Liu ◽  
Denggao Zhang ◽  
Ning Li ◽  
Yijie Xue ◽  
...  
Keyword(s):  
Cascade Cyclization ◽  
Radical Cascade

An iron-catalyzed radical cascade cyclization of oxime esters with isocyanides for the synthesis of 1-cyanoalkyl isoquinolines and 6-cyanoalkyl phenanthridines has been developed.

Catalytic Radical Cascade Cyclization of Alkene-Tethered Enones to Fused Bicyclic Cyclopropanols

2021 ◽  
Author(s):  
Ying Xie ◽  
Wei Huang ◽  
Song Qin ◽  
Shaomin Fu ◽  
Bo Liu
Keyword(s):  
Hydrogen Atom ◽  
Cascade Reaction ◽  
Hydrogen Atom Transfer ◽  
Atom Transfer ◽  
Trimethyl Borate ◽  
Cascade Cyclization ◽  
Radical Cascade ◽  
Privileged Scaffolds

An unprecedented hydrogen atom transfer-triggered intramolecular cascade reaction between alkene and enone is developed, using Fe(acac)3, PhSiH2(Oi-Pr) and trimethyl borate, to efficiently construct cis-fused bicyclic cyclopropanols, privileged scaffolds often found...

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