An environmentally benign regioselective synthesis of 2-benzyl-4-arylquinoline derivatives using aryl amines, styrene oxides and aryl acetylenes

2021 ◽  
Author(s):  
Saghir Ali ◽  
Abu T. Khan
Keyword(s):  
Regioselective Synthesis ◽  
Environmentally Benign ◽  
Aryl Amines ◽  
Aryl Acetylenes

2-Benzyl-4-aryl/heteroaryl quinolines.

Environmentally benign nucleophilic substitution reaction of arylalkyl halides in water using CTAB as the inverse phase transfer catalyst

2019 ◽  
Vol 43 (40) ◽  
pp. 16041-16045 ◽  
Author(s):  
Atul K. Godha ◽  
Jayaraman Thiruvengadam ◽  
Viswanadhan Abhilash ◽  
Prajwal Balgi ◽  
A. V. Narayanareddy ◽  
...  
Keyword(s):  
Nucleophilic Substitution ◽  
Substitution Reaction ◽  
Phase Transfer ◽  
Phase Transfer Catalyst ◽  
Regioselective Synthesis ◽  
Environmentally Benign ◽  
Nucleophilic Substitution Reaction ◽  
Active Methylene Compounds ◽  
Active Methylene ◽  
Inverse Phase Transfer Catalyst

An environmentally benign, scalable and highly selective C-arylalkylation of active methylene compounds is developed using CTAB as the inverse phase transfer catalyst. The methodology is also applicable to the regioselective synthesis of N-aralkyl/alkyl 2-pyridones.

Regioselective synthesis of substituted thiazoles via cascade reactions from 3-chlorochromones and thioamides

2020 ◽  
Vol 18 (31) ◽  
pp. 6162-6170
Author(s):  
Tianzi Dai ◽  
Chen Cui ◽  
Xueyu Qi ◽  
Yanshu Cheng ◽  
Qian He ◽  
...  
Keyword(s):  
Cascade Reactions ◽  
Cascade Reaction ◽  
Regioselective Synthesis ◽  
Environmentally Benign

An efficient and regioselective strategy to synthesize substituted thiazoles via a cascade reaction in an environmentally benign medium was developed.

ChemInform Abstract: An Expeditious and Environmentally Benign Preparation of Aryl Halides from Aryl Amines by Solvent-Free Grinding.

ChemInform ◽  
2011 ◽  
Vol 42 (13) ◽  
pp. no-no
Author(s):  
Mi Eun Moon ◽  
Younghwa Choi ◽  
Young Min Lee ◽  
Vaishali Vajpayee ◽  
Marina Trusova ◽  
...  
Keyword(s):  
Solvent Free ◽  
Aryl Halides ◽  
Environmentally Benign ◽  
Aryl Amines

Efficient and Regioselective Synthesis of Phenothiazine via Ferric Citrate Catalyzed C-S/C-N Cross-Coupling

2018 ◽  
Vol 16 (1) ◽  
pp. 16-24
Author(s):  
Tonmoy Chitta Das ◽  
Syed Aziz Imam Quadri ◽  
Mazahar Farooqui
Keyword(s):  
Cross Coupling ◽  
Ferric Citrate ◽  
Regioselective Synthesis ◽  
Environmentally Benign ◽  
Coupling Reactions ◽  
Atom Economy ◽  
Phenothiazine Derivatives ◽  
First Report ◽  
Cross Coupling Reactions ◽  
Benign Synthesis

Efficient C-S and C-N cross-coupling reactions have been developed for regioselective, scalable and environmentally benign synthesis of substituted phenothiazine derivatives. Cross-coupling reactions were demonstrated on various challenging substrates using non-toxic, highly economical, readily available ferric citrate as a catalyst to get desired product with high regioselectivity. Atom economy is the added advantage of this protocol since additional N-protection step before coupling and eventual deprotection of the same to obtain the desired product arenot required. To the best of our knowledge, this is the first report on the use of inexpensive ferric citrate as a catalyst without involving any ligand for the synthesis of regioselectively substituted phenothiazine.

Convenient KI-catalyzed regioselective synthesis of 2-sulfonylindoles using water as solvent

2017 ◽  
Vol 41 (11) ◽  
pp. 4277-4280 ◽  
Author(s):  
Hongjie Li ◽  
Xiaolong Wang ◽  
Jie Yan
Keyword(s):  
Regioselective Synthesis ◽  
Environmentally Benign ◽  
Water As Solvent

An environmentally benign procedure is developed for the preparation of 2-sulfonylindoles catalyzed by KI in water.

An expeditious and environmentally benign preparation of aryl halides from aryl amines by solvent-free grinding

2010 ◽  
Vol 51 (51) ◽  
pp. 6769-6771 ◽  
Author(s):  
Mi Eun Moon ◽  
Younghwa Choi ◽  
Young Min Lee ◽  
Vaishali Vajpayee ◽  
Marina Trusova ◽  
...  
Keyword(s):  
Solvent Free ◽  
Aryl Halides ◽  
Environmentally Benign ◽  
Aryl Amines

Synthesis and Characterization of GO-Chit-Ni Nanocomposite as a Recoverable Nanocatalyst for Reducing Nitroarenes in Water

2020 ◽  
Vol 17 (7) ◽  
pp. 523-531
Author(s):  
Mosayeb Sarvestani ◽  
Roya Azadi
Keyword(s):  
Fourier Transforms ◽  
Considerable Change ◽  
Environmentally Benign ◽  
X Ray Diffraction ◽  
Simple Method ◽  
Transmission Electron ◽  
Ir Transmission ◽  
Aryl Amines ◽  
Ft Ir

In the present study, nickel nanoparticles (Ni-NPs) immobilized on graphene oxide-chitosan (GO-Chit-Ni) have been synthesized and characterized as a catalyst for reduction of nitroarenes in water. For this purpose, GO has been functionalized with chitosan (GO-Chit). Then, Ni-NPs were immobilized on the surface of GO-Chit using a simple method. The GO-Chi-Ni nanocomposites were characterized using Fourier Transforms Infrared Spectroscopy (FT-IR), Transmission Electron Microscopy (TEM), X-Ray Diffraction Measurements (XRD), and Atomic Adsorption Spectrometry (AAS). The GO-Chi-Ni nanoparticles demonstrated appropriate catalytic activity in reducing nitroarenes to aryl amines in the existence of sodium borohydride (NaBH4) aqueous solution as a hydrogen source at 80oC. This catalytic system applies environmentally benign water as a solvent that is cheap, easily accessible, non-toxic, non-volatile, non-flammable and thermally stable. This type of catalyst can be applied several times with no considerable change in its performance.

scholarly journals Synthesis of Benzenesulfonamide Derivatives Via Ring Opening of Aziridines In The Presence of Magnetically Retrievable Graphene Based (CoFe@rGO) Nanohybrid.

2021 ◽  
Author(s):  
Ankush Sheoran ◽  
Komal ◽  
Jaspreet Kaur ◽  
Paramdeep Kaur ◽  
Jyoti Agarwal ◽  
...  
Keyword(s):  
Significant Loss ◽  
Solvent Free ◽  
Environmentally Benign ◽  
Nucleophilic Attack ◽  
Catalyst Loading ◽  
Aziridine Ring ◽  
Solvent Free Conditions ◽  
Aryl Amines ◽  
Ft Ir ◽  
Low Catalyst Loading

Abstract Graphene based magnetic nanohybrids have engrossed considerable research curiosity because of their exceptional properties and diverse applications associated with green chemistry. In this regard, a practical, facile and regioselective preparation of 1,2-diamines from N-tosylaziridine/(S)-(+)-2-Benzyl-1-(p-tolylsulfonyl)aziridine and aryl amines in the presence of magnetically separable graphene based nanohybrid (CoFe@rGO) has been proposed under mild and solvent free conditions. The FT-IR, FE-SEM, XRD and EDX spectroscopic analysis confirmed the formation of the CoFe@rGO nanohybrids. For unsymmetrical aziridine, nucleophilic attack of aryl amines was observed to take place selectively at the more substituted carbon atom of aziridine ring. Environmentally benign, efficient, shorter reaction time, solvent-free conditions, low catalyst loading, excellent reaction yields and reusability of the catalyst for six consecutive runs without significant loss in its activity are the key advantages of this protocol.

An Effective Heterogeneous Copper Catalyst System for C–N Coupling and Its Application in the Preparation of 2-Methyl-4-methoxydiphenylamine (MMDPA)

Synthesis ◽  
2018 ◽  
Vol 50 (19) ◽  
pp. 3911-3920 ◽  
Author(s):  
Manna Huang ◽  
Zhou Yi ◽  
Yiqian Wan ◽  
Xinhai Zhu
Keyword(s):  
Heterogeneous Catalyst ◽  
Copper Catalyst ◽  
Catalyst System ◽  
Environmentally Benign ◽  
Homogeneous Catalyst ◽  
Practical Application ◽  
Aryl Bromides ◽  
Aryl Amines ◽  
Type C ◽  
Work Up

A ligand-recyclable, environmentally benign heterogeneous catalyst system composed of CuI and polystyrene-supported N(-(4-(aminomethyl)naphthalen-1-yl)-N(-phenyl-1H-pyrrole-2-carbohydrazide (PSAP) has been established for Ullmann type C–N coupling based on the homogeneous catalyst system N′,N′-diphenyl-1H-pyrrole-2-carbohydrazide/CuI. This heterogeneous catalyst system maintained the catalytic effectiveness of the homogeneous catalyst. A variety of functionalized aryl bromides can be efficiently aminated with aryl amines and aliphatic amines with high selectivity for amines over alcohols. Moreover, a practical application of this catalyst system to promote the reaction of commercially available 4-methoxy-2-methylaniline and bromobenzene in 10 mmol scale, provided 2-methyl-4-methoxydiphenylamine (MMDPA) with 93% yield with the merit of the approach being simple operation for work-up and purification.

ChemInform Abstract: Deep Eutectic Solvent: A Simple, Environmentally Benign Reaction Media for Regioselective Synthesis of 2,3,4-Trisubstituted 1H-Pyrroles.

ChemInform ◽  
2015 ◽  
Vol 46 (35) ◽  
pp. no-no
Author(s):  
Hanuman P. Kalmode ◽  
Kamlesh S. Vadagaonkar ◽  
Kaliyappan Murugan ◽  
Sattey Prakash ◽  
Atul C. Chaskar
Keyword(s):  
Deep Eutectic Solvent ◽  
Regioselective Synthesis ◽  
Environmentally Benign ◽  
Reaction Media
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