ChemInform Abstract: Deep Eutectic Solvent: A Simple, Environmentally Benign Reaction Media for Regioselective Synthesis of 2,3,4-Trisubstituted 1H-Pyrroles.

ChemInform ◽  
2015 ◽  
Vol 46 (35) ◽  
pp. no-no
Author(s):  
Hanuman P. Kalmode ◽  
Kamlesh S. Vadagaonkar ◽  
Kaliyappan Murugan ◽  
Sattey Prakash ◽  
Atul C. Chaskar
Keyword(s):  
Deep Eutectic Solvent ◽  
Regioselective Synthesis ◽  
Environmentally Benign ◽  
Reaction Media

Deep eutectic solvent: a simple, environmentally benign reaction media for regioselective synthesis of 2,3,4-trisubstituted 1H-pyrroles

RSC Advances ◽  
2015 ◽  
Vol 5 (44) ◽  
pp. 35166-35174 ◽  
Author(s):  
Hanuman P. Kalmode ◽  
Kamlesh S. Vadagaonkar ◽  
Kaliyappan Murugan ◽  
Sattey Prakash ◽  
Atul C. Chaskar
Keyword(s):  
Deep Eutectic Solvent ◽  
Regioselective Synthesis ◽  
Environmentally Benign ◽  
Highly Efficient ◽  
Reaction Media

A greener, rapid and highly efficient synthetic protocol for the construction of pyrroles has been achieved.

Naturally Occurring Organic Acid-catalyzed Facile Diastereoselective Synthesis of Biologically Active (E)-3-(arylimino)indolin-2-one Derivatives in Water at Room Temperature

2019 ◽  
Vol 23 (16) ◽  
pp. 1778-1788 ◽  
Author(s):  
Gurpreet Kaur ◽  
Arvind Singh ◽  
Kiran Bala ◽  
Mamta Devi ◽  
Anjana Kumari ◽  
...  
Keyword(s):  
Room Temperature ◽  
Biologically Active ◽  
Environmentally Benign ◽  
Diastereoselective Synthesis ◽  
Substituted Anilines ◽  
Reaction Conditions ◽  
Naturally Occurring ◽  
Acid Catalyzed ◽  
Reaction Media ◽  
Column Chromatographic

A simple, straightforward and efficient method has been developed for the synthesis of (E)-3-(arylimino)indolin-2-one derivatives and (E)-2-((4-methoxyphenyl)imino)- acenaphthylen-1(2H)-one. The synthesis of these biologically-significant scaffolds was achieved from the reactions of various substituted anilines and isatins or acenaphthaquinone, respectively, using commercially available, environmentally benign and naturally occurring organic acids such as mandelic acid or itaconic acid as catalyst in aqueous medium at room temperature. Mild reaction conditions, energy efficiency, good to excellent yields, environmentally benign conditions, easy isolation of products, no need of column chromatographic separation and the reusability of reaction media are some of the significant features of the present protocol.

Application of Deep Eutectic Solvent (DES) as a Reaction Media for the Esterification of Acrylic Acid with n-Butanol

2015 ◽  
Vol 13 (3) ◽  
pp. 389-393 ◽  
Author(s):  
Emine Sert
Keyword(s):  
Catalytic Activity ◽  
Acrylic Acid ◽  
Batch Reactor ◽  
Choline Chloride ◽  
Deep Eutectic Solvent ◽  
Molar Ratio ◽  
Catalyst Loading ◽  
Toluene Sulfonic Acid ◽  
Effects Of Temperature ◽  
Reaction Media

Abstract Within the framework of green chemistry, catalysts should be met different criteria such as biodegradability, recyclability, flammability, non-toxicity and low price. Acidic deep eutectic solvent (DES) have been synthesized for this purpose, by mixing para-toluene sulfonic acid and choline chloride. The catalytic activity of DES was studied in the esterification of acrylic acid with n-butanol. The usage of DES as catalyst is simple, safe and cheap. The effects of temperature, catalyst loading, n-butanol/acrylic acid molar ratio on the conversion of acrylic acid were performed. The batch reactor experiments were carried out at temperatures of 338, 348, 358 and 368 K, molar ratio of butanol to acrylic acid of 1, 2,3 and catalyst loading of 10, 15, 20 and 90 g/L. 90.2% of acrylic acid conversion was achieved at a temperature of 358 K and catalyst loading of 20 g/L. Reusability of DES was investigated. Reusability and catalytic activity makes DES efficient as catalyst.

Environmentally benign nucleophilic substitution reaction of arylalkyl halides in water using CTAB as the inverse phase transfer catalyst

2019 ◽  
Vol 43 (40) ◽  
pp. 16041-16045 ◽  
Author(s):  
Atul K. Godha ◽  
Jayaraman Thiruvengadam ◽  
Viswanadhan Abhilash ◽  
Prajwal Balgi ◽  
A. V. Narayanareddy ◽  
...  
Keyword(s):  
Nucleophilic Substitution ◽  
Substitution Reaction ◽  
Phase Transfer ◽  
Phase Transfer Catalyst ◽  
Regioselective Synthesis ◽  
Environmentally Benign ◽  
Nucleophilic Substitution Reaction ◽  
Active Methylene Compounds ◽  
Active Methylene ◽  
Inverse Phase Transfer Catalyst

An environmentally benign, scalable and highly selective C-arylalkylation of active methylene compounds is developed using CTAB as the inverse phase transfer catalyst. The methodology is also applicable to the regioselective synthesis of N-aralkyl/alkyl 2-pyridones.

Deep Eutectic Solvent Promoted Regioselective Synthesis of Densely Functionalized Mono and Bisindolylalkenes from β ‐Ketodithioesters

2020 ◽  
Vol 5 (42) ◽  
pp. 13351-13357
Author(s):  
Thokchom Jeeta Devi ◽  
Thokchom Prasanta Singh ◽  
Rajkumar Romeshkumar Singh ◽  
Elangbam Holender Singh ◽  
Okram Mukherjee Singh
Keyword(s):  
Deep Eutectic Solvent ◽  
Regioselective Synthesis

ChemInform Abstract: Novel Broensted Acidic Deep Eutectic Solvent as Reaction Media for Esterification of Carboxylic Acid with Alcohols.

ChemInform ◽  
2012 ◽  
Vol 43 (52) ◽  
pp. no-no
Author(s):  
Valerio De Santi ◽  
Fabio Cardellini ◽  
Lucia Brinchi ◽  
Raimondo Germani
Keyword(s):  
Carboxylic Acid ◽  
Deep Eutectic Solvent ◽  
Reaction Media

Ionic Liquid Promoted Eco-friendly and Efficient Synthesis of Six-membered Npolyheterocycles

2018 ◽  
Vol 15 (8) ◽  
pp. 1124-1146 ◽  
Author(s):  
Navjeet Kaur
Keyword(s):  
Organic Chemistry ◽  
Ionic Liquid ◽  
Ionic Liquids ◽  
Organic Solvents ◽  
Review Article ◽  
Environmentally Benign ◽  
Wide Range ◽  
Catalyzed Reactions ◽  
Metal Catalyzed ◽  
Reaction Media

Background: The synthesis of N-polyheterocycles by environmentally benign method is highly attractive but challenging proposition. New strategies have been developed for the preparation of polycyclic heterocycles in the last decades. In this review article, the synthesis of nitrogen containing six-membered polycyclic heterocyclic compounds is presented with the application of ionic liquids. This contribution focuses on the literature related to the total synthesis of six-membered N-polyheterocycles. Objective: Ionic liquids not only acted as environmentally benign reaction media but also as catalysts which afforded the very promising replacements of traditional molecular solvents in organic chemistry due to their stability, non-flammability, non-volatility and ease of recyclability. Ionic liquids are utilized in metal catalyzed reactions in place of organic solvents in the last years. It has attracted considerable attention in recent years. Ionic liquids acted as alternatives of organic solvents and these ILs are environment friendly. Conclusion: In the area of green chemistry ionic liquid assisted synthesis is a very promising technique which afforded a flexible platform for the formation of heterocycles. The influence of ILs on the development of efficient and new synthetic protocols over the last decade for the construction of N-polyheterocycles is featured in this review article. These synthetic strategies will continue to attract more attention and will find a wide range of applications in organic synthesis. In conclusion, ionic liquids assisted syntheses have become an efficient and powerful tool in organic chemistry quickly.

Ionic liquid Mediated Synthesis of Schiff bases bearing thiazole and indole moieties

2020 ◽  
Vol 17 ◽  
Author(s):  
Dhanaji Jawale ◽  
Devendra Wagare ◽  
Dinesh Lingampalle ◽  
Prashant Netankar
Keyword(s):  
Ionic Liquid ◽  
Schiff Bases ◽  
Heterocyclic Compounds ◽  
Ammonium Acetate ◽  
Biologically Active ◽  
Environmentally Benign ◽  
Melting Points ◽  
Peg 400 ◽  
Reaction Media ◽  
Layer Chromatography

Aims: Ionic liquid Mediated Synthesis of Schiff bases bearing thiazole and indole moieties. Background: Synthesis of biologically active heterocyclic compounds using environmentally benign method. Materials and Methods: A mixture of amino thiazoles (3a-i) (20 mmol), indole-3-carboxyaldehyde (4) (20 mmol) and ionic liquid (80 mmol) was stirred in ethanol (30 mL) at r.t. The progress of the reaction was monitored by thin layer chromatography. After stirring the reaction mass for 2h the solid mass appeared in the reaction was filtered and crystalized using ethanol. The melting points and the yields of the derivatives are recorded in the Table 2. The filtrate was distilled and residue, ionic liquid was reused for the further reactions of the same batch and noted that it gave moderate to good yields of the products. Results and Discussion: Thus a convenient synthetic protocol for the synthesis of new Schiff bases, N-(4-(3-(4-(4- phenylthiazol-2-ylimino) methyl) phenoxy) propoxy) benzylidene)-4-phenylthiazol-2-amines, (8a-i) and N-((1H-indol-3-yl) methylene)-4-phenylthiazol-2-amines,(5a-i) has been developed by separately allowing the interactions of bis aldehyde (7) and 3-formyl indole (4) with amino thiazoles, (3a-i) in 2-hydroxy ethyl ammonium acetate, an ionic liquid, at r. t. (Scheme 1). Acetophenones, (1a-i) and thiourea were allowed to condense in PEG-400 in the presence of NBS and obtained better yields of aminothiazoles, (3a-i). Amino thiazoles when separately condensed with indole-3-carboxyaldehyde (4) and bis aldehyde (7) in ionic liquid, 2-hydroxy ethyl ammonium acetate (9) gave respective new azomethines, N-((1H-indol-3-yl) methylene)-4-phenylthiazol-2-amines, (5a-i) and N-(4-(3-(4-(4-phenylthiazol-2-ylimino) methyl) phenoxy) propoxy) benzylidene)-4-phenylthiazol-2-amine, (8a-i), respectively. Conclusion: We have synthesized new Schiff bases at r.t. using freshly prepared ionic liquid as medium. This method useful for the preparation of library of Schiff bases. The starting, material required for the synthesis of the Schiff bases, amino thiazoles have been prepared using green reaction media.

Solvent-mediated Highly Efficient Synthesis of [1,2,4]triazolo/benzimidazoloquinazolinone Derivatives

2020 ◽  
Vol 16 (8) ◽  
pp. 1185-1190 ◽  
Author(s):  
Fatemeh Malamiri ◽  
Samad Khaksar ◽  
Rashid Badri ◽  
Elham Tahanpesar
Keyword(s):  
Deep Eutectic Solvent ◽  
Efficient Synthesis ◽  
Melting Points ◽  
Reaction Conditions ◽  
Catalyst Free ◽  
Highly Efficient ◽  
Reaction Media

Objective: An efficient and catalyst-free procedure for the synthesis of [1,2,4]triazolo/benzimidazolo quinazolinones has been developed in 2,2,2-trifluoroethanol or deep eutectic solvent(DESs) as a clean reaction media. Methods: All of the obtained products are known compounds and identified by IR, 1HNMR,13CNMR, and melting points. Results: Various products were obtained in good to excellent yields under reaction conditions. Conclusion: We have efficiently developed a practical and catalyst-free approach for the synthesis of [1,2,4]triazolo/benzimidazolo quinazolinones employing TFE as a clean and reusable media.

Advances in the Synthesis of Xanthenes: An Overview

2018 ◽  
Vol 15 (3) ◽  
pp. 341-369 ◽  
Author(s):  
Ankita Chaudhary ◽  
Jitender M. Khurana
Keyword(s):  
Heterogeneous Catalysts ◽  
Biological Activities ◽  
Reaction Times ◽  
Environmentally Benign ◽  
Central Nucleus ◽  
Diversity Oriented Synthesis ◽  
Wide Range ◽  
Privileged Scaffold ◽  
Synthetic Methodologies ◽  
Reaction Media

Background: Xanthene is pharmacologically important oxygen containing heterocyclic moeity exhibiting an array of potent biological activities like antibacterial, antiviral, antiinflammatory, antitumor, antioxidant, antiplasmodial etc. Other useful applications of these heterocycles are as fluorescent materials for the visualization of biomolecules and in laser technology. Objective: This review gives an insight of the literature available on the methods for the construction of xanthene nucleus. This review article can be reasonably encouraging for those involved in the synthesis of molecules exhibiting a wide range of biological activities involving xanthene as central nucleus and would provide them assistance in developing new eco-friendly, efficient and economical viable methods. Conclusion: Owing to diverse applications of xanthenes, various synthetic methodologies have been developed, whether to construct this privileged scaffold. Many of the reported methods involve the use of various harsh catalysts/reagents that are not environmentally benign, produce a large amount of waste and need longer reaction times. The sustainable and diversity oriented synthesis of xanthene scaffold which incorporates Green Chemistry tools like multicomponent reaction approach, heterogeneous catalysts, alternate reaction media such as water, ionic liquids, polyethylene glycol etc. has also been developed.

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