Gemdimethyl Peptide Nucleic Acid (α/β/γ-gdm-PNA) Monomers: Synthesis and the Role of gdm-Substituents in Preferential Stabilisation of Z/E-Rotamers

2021 ◽  
Author(s):  
Pradnya Kulkarni ◽  
Dhrubajyoti Datta ◽  
Raghunath Ozhapakkam Ramabhadran ◽  
Krishna Ganesh
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Preferential Binding

The flexible backbone of aminoethylglycine (aeg) PNA upon substitution becomes sterically constrained to ordain conformational pre-organization for preferential binding to DNA or RNA. The bulky gemdimethyl (gdm) substitution on carbons...

Triplex-forming PNA modified with unnatural nucleobases: the role of protonation entropy in RNA binding

2016 ◽  
Vol 18 (47) ◽  
pp. 32002-32006 ◽  
Author(s):  
Tamaki Endoh ◽  
Chiara Annoni ◽  
Dziyana Hnedzko ◽  
Eriks Rozners ◽  
Naoki Sugimoto
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Rna Binding ◽  
Association Rate

Protonation entropy of 2-aminopyridine is responsible for decreased association rate and stability of triplex between peptide nucleic acid and RNA at higher pH.

Role of Different Receptor-Surface Binding Modes in the Morphological and Electrochemical Properties of Peptide-Nucleic-Acid-Based Sensing Platforms

Langmuir ◽  
2019 ◽  
Vol 35 (9) ◽  
pp. 3272-3283 ◽  
Author(s):  
Johannes D. Bartl ◽  
Paolo Scarbolo ◽  
Denis Brandalise ◽  
Martin Stutzmann ◽  
Marc Tornow ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Electrochemical Properties ◽  
Peptide Nucleic Acid ◽  
Binding Modes ◽  
Surface Binding ◽  
Sensing Platforms

Correction to Role of SbmA in the Uptake of Peptide Nucleic Acid (PNA)-Peptide Conjugates in E. coli

2014 ◽  
Vol 10 (2) ◽  
pp. 631-631 ◽  
Author(s):  
Anubrata Ghosal ◽  
Ally Vitali ◽  
James E. M. Stach ◽  
Peter E. Nielsen
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Peptide Conjugates ◽  
E Coli

Role of Nucleobase Energetics and Nucleobase Interactions in Single-Stranded Peptide Nucleic Acid Charge Transfer

2009 ◽  
Vol 131 (18) ◽  
pp. 6498-6507 ◽  
Author(s):  
Amit Paul ◽  
Silvia Bezer ◽  
Ravindra Venkatramani ◽  
Laura Kocsis ◽  
Emil Wierzbinski ◽  
...  
Keyword(s):  
Charge Transfer ◽  
Nucleic Acid ◽  
Peptide Nucleic Acid

Targeted gene delivery: the role of peptide nucleic acid

2003 ◽  
Vol 10 (3-4) ◽  
pp. 161-167 ◽  
Author(s):  
Kenneth W. Liang ◽  
Feng Liu ◽  
Leaf Huang
Keyword(s):  
Nucleic Acid ◽  
Gene Delivery ◽  
Peptide Nucleic Acid ◽  
Targeted Gene Delivery

Role of SbmA in the Uptake of Peptide Nucleic Acid (PNA)-Peptide Conjugates in E. coli

2012 ◽  
Vol 8 (2) ◽  
pp. 360-367 ◽  
Author(s):  
Anubrata Ghosal ◽  
Ally Vitali ◽  
James E.M. Stach ◽  
Peter E. Nielsen
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Peptide Conjugates ◽  
E Coli
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