Recent advances in the functionalization of polyfluoro(aza)aromatics via C–C coupling strategies

2021 ◽  
Author(s):  
Timofey D. Moseev ◽  
Mikhail V. Varaksin ◽  
Denis A. Gorlov ◽  
Valery N. Charushin ◽  
Oleg N. Chupakhin
Keyword(s):  
Transition Metal ◽  
Coupling Reactions ◽  
Metal Free ◽  
Recent Advances ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed ◽  
Coupling Strategies

This review highlights the recent advances in the functionalization of polyfluoro(aza)aromatics via both transition metal-catalyzed and metal-free C–C coupling reactions for the period from 2006 to the beginning of 2021.

Formal nucleophilic borylation and borylative cyclization of organic halides

2017 ◽  
Vol 15 (2) ◽  
pp. 285-300 ◽  
Author(s):  
K. Kubota ◽  
H. Iwamoto ◽  
H. Ito
Keyword(s):  
Transition Metal ◽  
Metal Free ◽  
Recent Advances ◽  
Organic Halides ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

Recent advances in borylations of organic halides, including both transition-metal-catalyzed and metal-free methods are summarized. Borylative cyclization is also discussed.

Recent Advances in Direct C–H Functionalization of Pyrimidines

Synthesis ◽  
2017 ◽  
Vol 50 (02) ◽  
pp. 193-210 ◽  
Author(s):  
Egor Verbitskiy ◽  
Gennady Rusinov ◽  
Oleg Chupakhin ◽  
Valery Charushin
Keyword(s):  
Transition Metal ◽  
Pyrimidine Derivatives ◽  
Metal Free ◽  
Recent Advances ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

Data spanning the period 2000–2017 on the direct C–H functionalization of pyrimidines are collected and discussed in this review. This demonstrates the surge of interest and creativity that this field of chemistry has experienced during the last two decades. Plausible applications of highly functionalized pyrimidines are also discussed.1 Introduction2 Transition-Metal-Catalyzed C–H Functionalization of Pyrimidine Derivatives3 Transition-Metal-Free Direct C–H Functionalization of Pyrimidine Derivatives4 Deprotonative Metalation of Pyrimidine Derivatives5 Conclusions

scholarly journals Recent Advances of Transition Metal-Catalyzed P-C Coupling Reactions

2017 ◽  
Vol 37 (2) ◽  
pp. 335 ◽  
Author(s):  
Changwei Shao ◽  
Weigang Xu ◽  
Liang Li ◽  
Xinghua Zhang
Keyword(s):  
Transition Metal ◽  
Coupling Reactions ◽  
Recent Advances ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

scholarly journals Recent Advances in the Addition of Amide/Sulfonamide Bonds to Alkynes

Molecules ◽  
2019 ◽  
Vol 24 (1) ◽  
pp. 164 ◽  
Author(s):  
Fei Zhao ◽  
Pinyi Li ◽  
Xiaoyan Liu ◽  
Xiuwen Jia ◽  
Jiang Wang ◽  
...  
Keyword(s):  
Transition Metal ◽  
Present Review ◽  
Reaction Conditions ◽  
Metal Free ◽  
Triple Bonds ◽  
Recent Advances ◽  
Direct Functionalization ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

The addition of amide/sulfonamide bonds to alkynes is not only one of the most important strategies for the direct functionalization of carbon–carbon triple bonds, but also a powerful tool for the downstream transformations of amides/sulfonamides. The present review provides a comprehensive summary of amide/sulfonamide bond addition to alkynes, including direct and metal-free aminoacylation, based-promoted aminoacylation, transition-metal-catalyzed aminoacylation, organocatalytic aminoacylation and transition-metal-catalyzed aminosulfonylation of alkynes up to December 2018. The reaction conditions, regio- and stereoselectivities, and mechanisms are discussed and summarized in detail.

scholarly journals Recent advances on the transition-metal-catalyzed synthesis of imidazopyridines: an updated coverage

2019 ◽  
Vol 15 ◽  
pp. 1612-1704 ◽  
Author(s):  
Gagandeep Kour Reen ◽  
Ashok Kumar ◽  
Pratibha Sharma
Keyword(s):  
Transition Metal ◽  
Transition Metals ◽  
Method Development ◽  
Deep Understanding ◽  
Catalyst Loading ◽  
Coupling Reactions ◽  
Reaction Conditions ◽  
Recent Advances ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

A comprehensive account of recent advances in the synthesis of imidazopyridines, assisted through transition-metal-catalyzed multicomponent reactions, C–H activation/functionalization and coupling reactions are highlighted in this review article. The basic illustration of this review comprises of schemes with concise account of explanatory text. The schemes depict the reaction conditions along with a quick look into the mechanism involved to render a deep understanding of the catalytic role. At some instances optimizations of certain features have been illustrated through tables, i.e., selectivity of catalyst, loading of the catalyst and percentage yield with different substrates. Each of the reported examples has been rigorously analyzed for reacting substrates, reaction conditions and transition metals used as the catalyst. This review will be helpful to the chemists in understanding the challenges associated with the reported methods as well as the future possibilities, both in the choice of substrates and catalysts. This review would be quite appealing to a wider range of organic chemists in academia and industrial R&D sectors working in the field of heterocyclic syntheses. In a nutshell, this review will be a guiding torch to envisage: (i) the role of various transition metals in the domain dedicated towards method development and (ii) for the modifications needed thereof in the R&D sector.

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