Selective photoredox direct arylations of aryl bromides in water in a microfluidic reactor

2021 ◽  
Vol 19 (13) ◽  
pp. 3016-3023
Author(s):  
Francesca Pallini ◽  
Elena Sangalli ◽  
Mauro Sassi ◽  
Philippe M. C. Roth ◽  
Sara Mattiello ◽  
...  
Keyword(s):  
High Selectivity ◽  
High Efficiency ◽  
Direct Arylation ◽  
Microfluidic Reactor ◽  
Aryl Bromides ◽  
Microflow Reactor

Performing photoredox direct arylation reactions under emulsion conditions in a microflow reactor enables high efficiency and high selectivity thanks to the favorable compartmentalization of the reagents and reactants.

scholarly journals Rhodium-catalyzed, P-directed selective C7 arylation of indoles

2018 ◽  
Vol 4 (12) ◽  
pp. eaau6468 ◽  
Author(s):  
Xiaodong Qiu ◽  
Hong Deng ◽  
Yue Zhao ◽  
Zhuangzhi Shi
Keyword(s):  
Present Method ◽  
Rational Design ◽  
High Selectivity ◽  
Vital Role ◽  
Direct Arylation ◽  
Formal Synthesis ◽  
Marine Alkaloid ◽  
Aryl Bromides ◽  
Directing Group ◽  
Selection Of

The indole scaffold will continue to play a vital role in the future of drug discovery and agrochemical development. Regioselective direct arylation of indoles on the benzenoid moiety is a challenging task due to the inherent reactivity of the C2 and C3 positions. Here, we have developed an effective strategy for the regioselective direct arylation of indoles at the C7 position with (hetero)aryl bromides by the rational design of a directing group. The key to the high selectivity and reactivity of this method is the appropriate selection of a class of directing groups, N-PR2(R =tBu andcHex), that are easily removed in the presence of the Wilkinson’s catalyst. Using the present method as a key step, formal synthesis of marine alkaloid dictyodendrin B has also been demonstrated.

scholarly journals Continuous-Flow Photocatalytic Microfluidic-Reactor for the Treatment of Aqueous Contaminants, Simplicity, and Complexity: A Mini-Review

Symmetry ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1325
Author(s):  
Zhongwei Gao ◽  
Changqing Pan ◽  
Chang-Ho Choi ◽  
Chih-Hung Chang
Keyword(s):  
Continuous Flow ◽  
Lower Energy ◽  
High Efficiency ◽  
Diffusion Length ◽  
Physical Adsorption ◽  
Chemical Oxidation ◽  
Microfluidic Reactor ◽  
Global Issue ◽  
The Individual ◽  
Aqueous Contaminants

Water pollution is a growing global issue; there are many approaches to treating wastewater, including chemical coagulation, physical adsorption, and chemical oxidation. The photocatalysis process has provided a solution for removing pollutants from wastewater, where the pair of the photoelectron and hole works through an asymmetric way to degrade the contaminants under UV irradiation. This method offers an alternative route for treating the pollutant with a lower energy cost, high efficiency, and fewer byproducts. A continuous-flow microfluidic reactor has a channel size from tens to thousands of micrometers, providing uniform irradiation and short diffusion length. It can enhance the conversion efficiency of photocatalysis due to the simple spatial symmetry inside the microreactor channel and among the individual channels. In addition, the bandgap of TiO2, ZnO, or other photocatalyst nanoparticles with symmetric crystal structure can be modified through doping or embedding. In this mini-review, a review of the reported continuous-flow photocatalytic microfluidic reactor is discussed from the perspective of both microreactor design and material engineering.

Direct Arylation of Heteroaromatic Compounds with Congested, Functionalised Aryl Bromides at Low Palladium/Triphosphane Catalyst Loading

2011 ◽  
Vol 17 (23) ◽  
pp. 6453-6461 ◽  
Author(s):  
David Roy ◽  
Sophal Mom ◽  
Dominique Lucas ◽  
Hélène Cattey ◽  
Jean‐Cyrille Hierso ◽  
...  
Keyword(s):  
Catalyst Loading ◽  
Direct Arylation ◽  
Heteroaromatic Compounds ◽  
Aryl Bromides

Metal-free graphdiyne doped with sp-hybridized boron and nitrogen atoms at acetylenic sites for high-efficiency electroreduction of CO2 to CH4 and C2H4

2019 ◽  
Vol 7 (8) ◽  
pp. 4026-4035 ◽  
Author(s):  
Jia Zhao ◽  
Zhe Chen ◽  
Jingxiang Zhao
Keyword(s):  
High Selectivity ◽  
High Efficiency ◽  
Metal Free

By carefully controlling the kinds and sites of the B or N dopant, graphdiyne can be utilized as a metal-free electrocatalyst with high-efficiency and high selectivity for CO2 reduction to C1 and C2 products.

Synthesis of conjugated polymers using aryl-bromides via Cu-catalyzed direct arylation polymerization (Cu-DArP)

2019 ◽  
Vol 10 (48) ◽  
pp. 6545-6550 ◽  
Author(s):  
Liwei Ye ◽  
Robert M. Pankow ◽  
Alexander Schmitt ◽  
Barry C. Thompson
Keyword(s):  
Conjugated Polymers ◽  
Copper Catalysts ◽  
Aryl Bromide ◽  
Direct Arylation ◽  
First Report ◽  
Aryl Bromides ◽  
Direct Arylation Polymerization

The first report on direct arylation polymerization with copper catalysts and aryl-bromide monomers expands the sustainability and practicality of DArP.

Tuning the electronic structures of monolayer triphosphides MP3 (M = Sn and Ge) for CO2 electroreduction through interface engineering: a theoretical prediction

2020 ◽  
Vol 22 (13) ◽  
pp. 6896-6905 ◽  
Author(s):  
Zhongxu Wang ◽  
Jingxiang Zhao
Keyword(s):  
Charge Transfer ◽  
Theoretical Prediction ◽  
Electronic Structures ◽  
High Selectivity ◽  
High Efficiency ◽  
Interface Engineering ◽  
Dft Computations ◽  
Co2 Electroreduction

By DFT computations, SnP3 and GeP3 monolayers were identified as hopeful electrocatalysts with high-efficiency and high-selectivity for CO2 reduction by interface engineering with graphene, which is ascribed to the charge transfer at the interface.

Direct Arylation of Porphyrins with π-Extended Aryl Bromides under Ligand-free Fagnou-Hartwig Conditions

2013 ◽  
Vol 2 (4) ◽  
pp. 320-324 ◽  
Author(s):  
Yutaro Yamamoto ◽  
Sumito Tokuji ◽  
Takayuki Tanaka ◽  
Hideki Yorimitsu ◽  
Atsuhiro Osuka
Keyword(s):  
Direct Arylation ◽  
Aryl Bromides ◽  
Ligand Free
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