A Chloride-Doped Silver-Sulfide Cluster [Ag148S26Cl30(C≡CBut)60]6+: Hierarchical Assembly, Enhanced Luminescence and Cytotoxicity to Cancer Cells

Nanoscale ◽  
2022 ◽  
Author(s):  
Zhan-Guo Jiang ◽  
Wei-Hong Wu ◽  
Bo-Xing Jin ◽  
Hui-Min Zeng ◽  
Zhi-Gang Jin ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Silver Sulfide ◽  
Hierarchical Assembly ◽  
Potential Applications ◽  
Enhanced Luminescence ◽  
Sulfide Cluster

The formation of high-nuclear silver(I) clusters remains elusive and their potential applications are still underdeveloped. Herein, we report a unprecedented gigantic Ag148 ([Ag148S26Cl30(C≡CBut)60](SbF6)6) cluster co-templated by Cl- and S2-, which...

scholarly journals Enhanced luminescence properties of Ca1+xSr2−xAl2O6:Eu3+ (0 ≤ x ≤ 1) red phosphors based on composition modulation

RSC Advances ◽  
2021 ◽  
Vol 11 (21) ◽  
pp. 12981-12989
Author(s):  
Biao Shen ◽  
Jianghang Xu ◽  
Qinan Mao ◽  
Jiasong Zhong
Keyword(s):  
Optical Properties ◽  
Quantum Efficiency ◽  
Luminescence Properties ◽  
Composition Modulation ◽  
Red Phosphors ◽  
Potential Applications ◽  
Enhanced Luminescence

A series of Ca1+xSr2−xAl2O6:Eu3+ (0 ≤ x ≤ 1) red-emitting phosphors with adjustable optical properties and excellent quantum efficiency was developed for potential applications in warm WLEDs.

scholarly journals Demethylzeylasteral (T-96) Initiates Extrinsic Apoptosis Against Prostate Cancer cells by Inducing ROS-Mediated ER Stress and Suppressing Autophagic Flux

2021 ◽  
Author(s):  
Dong-Lin Yang ◽  
Ya-jun Zhang ◽  
Liu-jun He ◽  
Chun-sheng Hu ◽  
Li-xia Gao ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Er Stress ◽  
Cancer Cells ◽  
Autophagic Flux ◽  
Dependent Manner ◽  
Mechanistic Investigation ◽  
Potential Applications ◽  
Extrinsic Apoptosis ◽  
Pharmacologically Active

Abstract Demethylzeylasteral (T-96), a pharmacologically active triterpenoid monomer extracted from Tripterygiumwilfordii Hook F (TWHF), has been reported to exhibit anti-neoplastic effect on several types of cancer cells. However,whether it has the anti-tumour capability in human Prostate cancer (CaP)cells and what’s the precise regulatory mechanisms underlying the anti-proliferation effect of T-96 on human CaP. In the current study, T-96 exerted significant cytotoxicity to CaP cells in vitro and induced cell cycle arrest at S-phase in a dose-dependent manner. Furthermore, mechanistic investigation indicated that through inducing endoplasmic reticulum (ER) stress caused by intracellular accumulation of reactive oxygen species (ROS), T-96 significantly promoted autophagy initiation while blocked the autophagic flux and finally caused extrinsic apoptosis in CaP cells, implying that ER stress induced byT-96 initiated caspase dependent apoptosis to inhibit CaP cells. Moreover, as a novel lethal ER stress inducer, T-96 was capable to enhance the sensitivity of CaP cells to chemotherapeutic drug cisplatin. Taken together, our data implied that T-96 is a novel ER stress and autophagy modulator, and has the potential applications for CaP therapy in clinic.

scholarly journals ID: 1038 Hydrothermal synthesis of carbon nanodots from millets for cancer cells imaging

2017 ◽  
Vol 4 (S) ◽  
pp. 116
Author(s):  
Quang Ngo Khoa ◽  
Tran Thi Xuan Thuy ◽  
Che Thi Cam Ha
Keyword(s):  
Hydrothermal Synthesis ◽  
Cancer Cells ◽  
Biomedical Application ◽  
Average Diameter ◽  
Optical Measurements ◽  
Carbon Nanodots ◽  
Excitation Wavelength ◽  
Economical Method ◽  
Potential Applications ◽  
Multicolor Fluorescence

We presented a green, simple and economical method to synthesize carbon nanodots (C-dots) from millets using hydrothermal synthesis route. The obtained C-dots have average diameter ranging from 6 to 8 nm. Optical measurements showed the formation of hydroxyl, carbonyl/carboxyl, amino functional groups on the particle surfaces, resulting in their high hydrophilicity and bioconjugation. After treatment with C-dots, human cervical and lung cancer cells became bright and exhibited multicolor fluorescence under different excitation wavelength. The achievement demonstrated potential applications of fluorescent C-dots in the field of biomedical application, especially in diagnostic disease techniques.

Synthesis of surface functionalized hollow microporous organic capsules for doxorubicin delivery to cancer cells

2020 ◽  
Vol 11 (12) ◽  
pp. 2110-2118 ◽  
Author(s):  
Shumaila Razzaque ◽  
Ying Cheng ◽  
Irshad Hussain ◽  
Bien Tan
Keyword(s):  
Cancer Cells ◽  
Anticancer Drugs ◽  
Targeted Delivery ◽  
Potential Applications ◽  
Doxorubicin Delivery

Functionalized hypercrosslinked hollow microporous capsules are demonstrated to have potential applications in targeted delivery of anticancer drugs.

Octanuclear Silver Sulfide Cluster [Ag8(µ8-S)(µ-mimt)12](NO3)6Containing the First Thione-Stabilized Ag8Cube Caging a Sulfide Anion

2016 ◽  
Vol 2016 (21) ◽  
pp. 3380-3383 ◽  
Author(s):  
Yali Shen ◽  
Shuzhen Liu ◽  
Peipei Sun ◽  
Chunying Tang ◽  
Dingxian Jia
Keyword(s):  
Silver Sulfide ◽  
Sulfide Cluster

scholarly journals A Small Vimentin-Binding Molecule Blocks Cancer Exosome Release and Reduces Cancer Cell Mobility

2021 ◽  
Vol 12 ◽  
Author(s):  
Jianping Wu ◽  
Qian Xie ◽  
Yanjun Liu ◽  
Yanan Gao ◽  
Zhipeng Qu ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cancer Cell ◽  
Migration And Invasion ◽  
Intermediate Filament Protein ◽  
Cancer Cell Growth ◽  
Potential Applications ◽  
Health And Disease ◽  
Quantitative Analyses ◽  
Filament Protein

Vimentin is an intermediate filament protein with diverse roles in health and disease far beyond its structural functions. Exosomes or small extracellular vesicles (sEVs) are key mediators for intercellular communication, contributing to tissue homeostasis and the progression of various diseases, especially the metastasis of cancers. In this study, we evaluated a novel vimentin-binding compound (R491) for its anti-cancer activities and its roles in cancer exosome release. The compound R491 induced a rapid and reversible intracellular vacuolization in various types of cancer cells. This phenotype did not result in an inhibition of cancer cell growth, which was consistent with our finding from a protein array that R491 did not reduce levels of major oncoproteins in cancer cells. Morphological and quantitative analyses on the intracellular vacuoles and extracellular exosomes revealed that in response to R491 treatment, the exosomes released from the cells were significantly reduced, while the exosomes retained as intra-luminal vesicles inside the cells were subsequently degraded. Vim+/− cells had lower amounts of vimentin and accordingly, lower amounts of both the retained and the released exosomes than Vim+/+ cells had, while the vimentin-binding compound R491 inhibited only the release of exosomes. Further functional tests showed that R491 significantly reduced the migration and invasion of cancer cells in vitro and decreased the amount of exosome in the blood in mice. Our study suggests that vimentin promotes exosome release, and small-molecule compounds that target vimentin are able to both block cancer exosome release and reduce cancer cell motility, and therefore could have potential applications for inhibiting cancer invasive growth.

Hierarchical Assembly of DNA Origami Nanostructures Using Coiled-coil Peptides

2019 ◽  
Author(s):  
Alex Buchberger ◽  
Chad Simmons ◽  
Nour Fahmi ◽  
Ronit Freeman ◽  
Nicholas Stephanopoulos
Keyword(s):  
Self Assembly ◽  
Coiled Coil ◽  
Dna Origami ◽  
Hybrid Nanostructures ◽  
Hierarchical Assembly ◽  
Alternating Copolymer ◽  
Self Assembling ◽  
Potential Applications ◽  
Multiple Routes ◽  
Stepwise Assembly

DNA and peptides are two of the most commonly used biomolecules for building self-assembling materials, but few examples exist of hybrid nanostructures that contain both components. Here we report the modification of two peptides that comprise a coiled-coil heterodimer pair with orthogonal DNA handles in order to link DNA origami nanostructures bearing complementary strands into micrometer long one-dimensional arrays. We probed the effect of number of coils on self-assembly and demonstrated the formation of self-assembled structures through multiple routes, to form dimers and trimers, an alternating copolymer of two different origami bundles, and stepwise assembly of purified structures with coiled-coil conjugates. Our results demonstrate the successful merging of two distinct self-assembly modes to create hybrid bionanomaterials expected to have a range of potential applications in the future.

Multimodal evaluation of 19F-BPA internalization in pancreatic cancer cells for boron capture and proton therapy potential applications

2022 ◽  
Vol 94 ◽  
pp. 75-84
Author(s):  
Andrea Ciardiello ◽  
Saverio Altierix ◽  
Francesca Ballarini ◽  
Valerio Bocci ◽  
Silva Bortolussi ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Proton Therapy ◽  
Pancreatic Cancer Cells ◽  
Potential Applications

The Role of Adhesion in Gold Nanoparticles for Cancer Detection and Treatment

2015 ◽  
Vol 1132 ◽  
pp. 72-86
Author(s):  
Y. Oni ◽  
J.D. Obayemi ◽  
K. Kao ◽  
S. Dozie-Nwachukwu ◽  
S. Odusanya ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gold Nanoparticles ◽  
Cancer Cells ◽  
Cancer Detection ◽  
Breast Cancer Cells ◽  
Au Nanoparticle ◽  
Adhesion Forces ◽  
Force Microscopy ◽  
Nanoparticle Clusters ◽  
Potential Applications

This paper presents the results of an experimental study of the effects of adhesion between gold nanoparticles and surfaces that are relevant to the potential applications in cancer detection and treatment. Adhesion is measured using a dip coating/atomic force microscopy (DC/AFM) technique. The adhesion forces are obtained for dip-coated gold nanoparticles that interact with peptide or antibody-based molecular recognition units (MRUs) that attach specifically to breast cancer cells. They include MRUs that attach specifically to receptors on breast cancer cells. Adhesion forces between anti-cancer drugs such as paclitaxel, and the constituents of MRU-conjugated Au nanoparticle clusters, are measured using force microscopy techniques. The implications of the results are then discussed for the design of robust gold nanoparticle clusters and for potential applications in localized drug delivery and hyperthermia.

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