Integration of a Capacitor to 3-D DNA Walker and Biofuel Cell-Based Self-Powered System for Ultrasensitive Bioassays of MicroRNA

Nanoscale ◽  
2021 ◽  
Author(s):  
Fu-Ting Wang ◽  
Ke-Jing Huang ◽  
Yangyang Hou ◽  
Xuecai Tan ◽  
Xu Wu ◽  
...  

A self-powered microRNAs biosensor with triple signal amplification systems is assembled through integration of three-dimensional DNA walker, enzymatic biofuel cells and capacitor. The DNA walker is designed from an enzyme-free...

2020 ◽  
Vol 8 (7) ◽  
pp. 1389-1395 ◽  
Author(s):  
Fu-Ting Wang ◽  
Yi-Han Wang ◽  
Jing Xu ◽  
Ke-Jing Huang

A high-energy self-powered sensing platform for the ultrasensitive detection of proteins is developed based on enzymatic biofuel cells (EBFCs) by using DNA bioconjugate assisted signal amplification.


2020 ◽  
Vol 5 (41) ◽  
pp. eaaz7946 ◽  
Author(s):  
You Yu ◽  
Joanna Nassar ◽  
Changhao Xu ◽  
Jihong Min ◽  
Yiran Yang ◽  
...  

Existing electronic skin (e-skin) sensing platforms are equipped to monitor physical parameters using power from batteries or near-field communication. For e-skins to be applied in the next generation of robotics and medical devices, they must operate wirelessly and be self-powered. However, despite recent efforts to harvest energy from the human body, self-powered e-skin with the ability to perform biosensing with Bluetooth communication are limited because of the lack of a continuous energy source and limited power efficiency. Here, we report a flexible and fully perspiration-powered integrated electronic skin (PPES) for multiplexed metabolic sensing in situ. The battery-free e-skin contains multimodal sensors and highly efficient lactate biofuel cells that use a unique integration of zero- to three-dimensional nanomaterials to achieve high power intensity and long-term stability. The PPES delivered a record-breaking power density of 3.5 milliwatt·centimeter−2 for biofuel cells in untreated human body fluids (human sweat) and displayed a very stable performance during a 60-hour continuous operation. It selectively monitored key metabolic analytes (e.g., urea, NH4+, glucose, and pH) and the skin temperature during prolonged physical activities and wirelessly transmitted the data to the user interface using Bluetooth. The PPES was also able to monitor muscle contraction and work as a human-machine interface for human-prosthesis walking.


2020 ◽  
Vol 56 (14) ◽  
pp. 2135-2138 ◽  
Author(s):  
Xue-Jiao Yang ◽  
Mei-Rong Cui ◽  
Xiang-Ling Li ◽  
Hong-Yuan Chen ◽  
Jing-Juan Xu

We construct a target-triggered, self-powered 3D DNA walker for achieving intracellular signal amplification and sensitive imaging analysis of microRNAs.


2014 ◽  
Vol 20 (39) ◽  
pp. 12453-12462 ◽  
Author(s):  
Yanhu Wang ◽  
Lei Ge ◽  
Chao Ma ◽  
Qingkun Kong ◽  
Mei Yan ◽  
...  

Biosensors ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 41
Author(s):  
Jefferson Honorio Franco ◽  
Shelley D. Minteer ◽  
Adalgisa R. De Andrade

Biofuel cells use chemical reactions and biological catalysts (enzymes or microorganisms) to produce electrical energy, providing clean and renewable energy. Enzymatic biofuel cells (EBFCs) have promising characteristics and potential applications as an alternative energy source for low-power electronic devices. Over the last decade, researchers have focused on enhancing the electrocatalytic activity of biosystems and on increasing energy generation and electronic conductivity. Self-powered biosensors can use EBFCs while eliminating the need for an external power source. This review details improvements in EBFC and catalyst arrangements that will help to achieve complete substrate oxidation and to increase the number of collected electrons. It also describes how analytical techniques can be employed to follow the intermediates between the enzymes within the enzymatic cascade. We aim to demonstrate how a high-performance self-powered sensor design based on EBFCs developed for ethanol detection can be adapted and implemented in power devices for biosensing applications.


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