Effective Tumor Vessel Barrier Disruption Mediated by Perfluoro-N-(4-methylcyclohexyl) Piperidine Nanoparticles to Enhance the Efficacy of Photodynamic Therapy

Nanoscale ◽  
2021 ◽  
Author(s):  
Jianliang Shen ◽  
Wei Xiong ◽  
Lin Qi ◽  
Deli Si ◽  
Xin Jiang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Vessel ◽  
Drug Permeation ◽  
Barrier Disruption ◽  
Oxygen Perfusion

Currently, limited tumor drug permeation, poor oxygen perfusion and immunosuppression microenvironment are the most important bottlenecks that significantly reduce the efficacy of photodynamic therapy (PDT). The main cause of these...

Sialic acid-modified mesoporous polydopamine induces tumor vessel normalization to enhance photodynamic therapy by inhibiting VE-cadherin internalization

2021 ◽  
Vol 414 ◽  
pp. 128743
Author(s):  
Xiao-Ling Xu ◽  
Mei-Xuan Chen ◽  
Xue-Fang Lou ◽  
Yu-Yin Du ◽  
Gao-Feng Shu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Sialic Acid ◽  
Tumor Vessel ◽  
Vessel Normalization

scholarly journals Vascular Shutdown by Photodynamic Therapy Using Talaporfin Sodium

Cancers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2369
Author(s):  
Taketo Suzuki ◽  
Mamoru Tanaka ◽  
Makiko Sasaki ◽  
Hiroshi Ichikawa ◽  
Hirotada Nishie ◽  
...  
Keyword(s):  
Blood Flow ◽  
Photodynamic Therapy ◽  
Fiber Formation ◽  
Actin Dynamics ◽  
Pathological Examination ◽  
Tumor Blood Flow ◽  
Tumor Vessel ◽  
Talaporfin Sodium ◽  
Mlc Phosphorylation

Photodynamic therapy (PDT) is an attractive cancer treatment modality. Talaporfin sodium, a second-generation photosensitizer, results in lower systemic toxicity and relatively better selective tumor destruction than first-generation photosensitizers. However, the mechanism through which PDT induces vascular shutdown is unclear. In this study, the in vitro effects of talaporfin sodium-based PDT on human umbilical vein endothelial cells (HUVECs) were determined through cell viability and endothelial tube formation assays, and evaluation of the tubulin and F-actin dynamics and myosin light chain (MLC) phosphorylation. Additionally, the effects on tumor blood flow and tumor vessel destruction were assessed in vivo. In the HUVECs, talaporfin sodium-based PDT induced endothelial tube destruction and microtubule depolymerization, triggering the formation of F-actin stress fibers and a significant increase in MLC phosphorylation. However, pretreatment with the Rho-associated protein kinase (ROCK) inhibitor, Y27632, completely prevented PDT-induced stress fiber formation and MLC phosphorylation. The in vivo analysis and pathological examination revealed that the PDT had significantly decreased the tumor blood flow and the active area of the tumor vessel. We concluded that talaporfin sodium-based PDT induces the shutdown of existing tumor vessels via the RhoA/ROCK pathway by activating the Rho-GTP pathway and decreasing the tumor blood flow.

Construction of a near-infrared responsive upconversion nanoplatform against hypoxic tumors via NO-enhanced photodynamic therapy

Nanoscale ◽  
2020 ◽  
Vol 12 (14) ◽  
pp. 7875-7887 ◽  
Author(s):  
Ying Lan ◽  
Xiaohui Zhu ◽  
Ming Tang ◽  
Yihan Wu ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Upconversion Nanoparticles

A near-infrared (NIR) activated theranostic nanoplatform based on upconversion nanoparticles (UCNPs) is developed in order to overcome the hypoxia-associated resistance in photodynamic therapy by photo-release of NO upon NIR illumination.

Porphyrin-functionalized coordination star polymers and their potential applications in photodynamic therapy

2019 ◽  
Vol 10 (45) ◽  
pp. 6116-6121 ◽  
Author(s):  
Tan Ji ◽  
Lei Xia ◽  
Wei Zheng ◽  
Guang-Qiang Yin ◽  
Tao Yue ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Self Assembly ◽  
Star Polymers ◽  
New Family ◽  
Potential Applications

We present a new family of porphyrin-functionalized coordination star polymers prepared through combination of coordination-driven self-assembly and post-assembly polymerization. Their self-assembly behaviour in water and potential for photodynamic therapy were demonstrated.

A nitroreductase-activatable near-infrared theranostic photosensitizer for photodynamic therapy under mild hypoxia

2020 ◽  
Vol 56 (43) ◽  
pp. 5819-5822
Author(s):  
Jing Zheng ◽  
Yongzhuo Liu ◽  
Fengling Song ◽  
Long Jiao ◽  
Yingnan Wu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Triplet State ◽  
Near Infrared ◽  
Mild Hypoxia

In this study, a near-infrared (NIR) theranostic photosensitizer was developed based on a heptamethine aminocyanine dye with a long-lived triplet state.

Dinuclear phosphorescent rhenium(i) complexes as potential anticancer and photodynamic therapy agents

2020 ◽  
Vol 49 (33) ◽  
pp. 11583-11590 ◽  
Author(s):  
Zheng-Yin Pan ◽  
Dai-Hong Cai ◽  
Liang He
Keyword(s):  
Photodynamic Therapy ◽  
Cell Apoptosis ◽  
Lysosomal Dysfunction ◽  
Intracellular Ros

Two dinuclear organometallic Re(i) complexes increase intracellular ROS levels, causing lysosomal dysfunction and cell apoptosis.

Involvement of CFTR in photodynamic therapy-mediated apoptosis

2010 ◽  
Vol 34 (8) ◽  
pp. S44-S44
Author(s):  
Juan Juan Chen ◽  
Xiao Hua Jiang ◽  
Hsiao Chang Chan
Keyword(s):  
Photodynamic Therapy

Hypericin is an encouraging new photosensitizer for photodynamic therapy of esophageal dysplasia/cancer: Antiproliferative and apoptotic effects

2001 ◽  
Vol 120 (5) ◽  
pp. A443-A443
Author(s):  
M LENZ ◽  
M HOEPFNER ◽  
A THEISS ◽  
B LAMPE ◽  
H KASHTAN ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Esophageal Dysplasia ◽  
Apoptotic Effects
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