Ribosomally synthesized peptides, foreground players in microbial interactions: recent developments and unanswered questions

2021 ◽  
Author(s):  
Sylvie Rebuffat
Keyword(s):  
Current Knowledge ◽  
Complex Interaction ◽  
Microbial Interactions ◽  
Interaction Networks ◽  
Recent Developments

This review unveils current knowledge on the complex interaction networks involving ribosomally synthesized peptides, either modified or not, being at play in microbial interactions and symbioses.

scholarly journals Many-Objective Optimization for Anomaly Detection on Multi-Layer Complex Interaction Networks

2021 ◽  
Vol 11 (9) ◽  
pp. 4005
Author(s):  
Asep Maulana ◽  
Martin Atzmueller
Keyword(s):  
Anomaly Detection ◽  
Complex Networks ◽  
Pareto Front ◽  
Scoring Function ◽  
Cyber Physical Systems ◽  
Complex Interaction ◽  
Interaction Networks ◽  
Physical Systems ◽  
Human Interactions ◽  
Different Levels

Anomaly detection in complex networks is an important and challenging task in many application domains. Examples include analysis and sensemaking in human interactions, e.g., in (social) interaction networks, as well as the analysis of the behavior of complex technical and cyber-physical systems such as suspicious transactions/behavior in financial or routing networks; here, behavior and/or interactions typically also occur on different levels and layers. In this paper, we focus on detecting anomalies in such complex networks. In particular, we focus on multi-layer complex networks, where we consider the problem of finding sets of anomalous nodes for group anomaly detection. Our presented method is based on centrality-based many-objective optimization on multi-layer networks. Starting from the Pareto Front obtained via many-objective optimization, we rank anomaly candidates using the centrality information on all layers. This ranking is formalized via a scoring function, which estimates relative deviations of the node centralities, considering the density of the network and its respective layers. In a human-centered approach, anomalous sets of nodes can then be identified. A key feature of this approach is its interpretability and explainability, since we can directly assess anomalous nodes in the context of the network topology. We evaluate the proposed method using different datasets, including both synthetic as well as real-world network data. Our results demonstrate the efficacy of the presented approach.

scholarly journals T regulatory cells in childhood arthritis – novel insights

2013 ◽  
Vol 15 ◽  
Author(s):  
Anne M. Pesenacker ◽  
Lucy R. Wedderburn
Keyword(s):  
T Cells ◽  
Juvenile Idiopathic Arthritis ◽  
Regulatory T Cells ◽  
T Regulatory Cells ◽  
Current Knowledge ◽  
Autoimmune Arthritis ◽  
Regulatory Cells ◽  
New Developments ◽  
Childhood Arthritis ◽  
Recent Developments

In recent years, there have been many new developments in the field of regulatory T cells (Treg), challenging the consensus on their behaviour, classification and role(s) in disease. The role Treg might play in autoimmune disease appears to be more complex than previously thought. Here, we discuss the current knowledge of regulatory T cells through animal and human research and illustrate the recent developments in childhood autoimmune arthritis (juvenile idiopathic arthritis (JIA)). Furthermore, this review summarises our understanding of the fields and assesses current and future implications for Treg in the treatment of JIA.

The Salivary miRNome: A Promising Biomarker of Disease

MicroRNA ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Sara Tomei ◽  
Harshitha Shobha Manjunath ◽  
Selvasankar Murugesan ◽  
Souhaila Al Khodor
Keyword(s):  
Current Knowledge ◽  
Transcriptional Level ◽  
Biological Processes ◽  
Circulating Mirnas ◽  
Disease Pathogenesis ◽  
Technical Aspects ◽  
Recent Developments ◽  
Health And Disease ◽  
Non Coding Rnas

: MicroRNAs (miRNAs) are non-coding RNAs ranging from 18-24 nucleotides also known to regulate the human genome mainly at the post-transcriptional level. MiRNAs were shown to play an important role in most biological processes such as apoptosis and in the pathogenesis of many diseases such as cardiovascular diseases and cancer. Recent developments of advanced molecular high-throughput technologies have enhanced our knowledge of miRNAs. MiRNAs can now be discovered, interrogated, and quantified in various body fluids, and hence can serve as diagnostic and therapeutic markers for many diseases. While most studies use blood as a sample source to measure circulating miRNAs as possible biomarkers for disease pathogenesis, fewer studies have assessed the role of salivary miRNAs in health and disease. This review aims at providing an overview of the current knowledge of the salivary miRNome, addressing the technical aspects of saliva sampling and highlighting the applicability of miRNA screening to clinical practice.

Cloud Crime and Fraud

2019 ◽  
pp. 1159-1175
Author(s):  
Nimisha Singh
Keyword(s):  
Cloud Computing ◽  
Law Enforcement ◽  
Current Knowledge ◽  
Organizational Level ◽  
Law Enforcement Agencies ◽  
Policy Makers ◽  
Security Breaches ◽  
Recent Developments ◽  
Standards And Guidelines ◽  
Developed Nations

Changing trends in IT industry are opening new avenues. With the scalability, flexibility, and economic advantage offered by cloud computing, more and more organizations are moving towards cloud for their applications. With all the benefits of cloud computing, it poses a danger of digital crime and security breaches. These challenges are compounded by the fact that cybercrime and the transgressors transcend geographical boundaries while the law enforcement does not. This paper tries to focus on how cloud computing is rising to the challenges thrown in from cyber space and recent developments to avoid and mitigate cloud fraud and abuse. Taking counter measures at organizational level, will alleviate and up to an extent eliminate security breaches. With current knowledge on policy and standards adopted by developed nations, the policy makers and law enforcement agencies in developing countries can work towards formulating standards and guidelines for awareness on threats, vulnerabilities and effectiveness of security controls to respond to risk.

Cloud Crime and Fraud

2018 ◽  
pp. 1334-1350
Author(s):  
Nimisha Singh
Keyword(s):  
Cloud Computing ◽  
Law Enforcement ◽  
Current Knowledge ◽  
Organizational Level ◽  
Law Enforcement Agencies ◽  
Policy Makers ◽  
Security Breaches ◽  
Recent Developments ◽  
Standards And Guidelines ◽  
Developed Nations

Changing trends in IT industry are opening new avenues. With the scalability, flexibility, and economic advantage offered by cloud computing, more and more organizations are moving towards cloud for their applications. With all the benefits of cloud computing, it poses a danger of digital crime and security breaches. These challenges are compounded by the fact that cybercrime and the transgressors transcend geographical boundaries while the law enforcement does not. This paper tries to focus on how cloud computing is rising to the challenges thrown in from cyber space and recent developments to avoid and mitigate cloud fraud and abuse. Taking counter measures at organizational level, will alleviate and up to an extent eliminate security breaches. With current knowledge on policy and standards adopted by developed nations, the policy makers and law enforcement agencies in developing countries can work towards formulating standards and guidelines for awareness on threats, vulnerabilities and effectiveness of security controls to respond to risk.

Molecular ecology of plant-microbial interactions during invasions: progress and challenges.

2020 ◽  
pp. 340-362
Author(s):  
Johannes J. le Roux
Keyword(s):  
Dna Barcoding ◽  
Invasive Plants ◽  
Invasive Plant ◽  
Molecular Ecology ◽  
Plant Invasions ◽  
Microbial Interactions ◽  
Interaction Networks ◽  
Future Research ◽  
Evolutionary Information ◽  
Molecular Approaches

Abstract Microbes are omnipresent, yet their interactions with invasive plants remain understudied. This is surprising, given the importance of microbes in plant community ecology and their influence on plant performance in new environments. Recent advances in molecular genetic approaches have opened the door to studying this unseen majority in great detail and to understand how they fit into ecological interaction networks. Molecular approaches allow rapid assessments of microbial diversity at reasonable cost while providing both taxonomic and evolutionary information. Here I discuss how these approaches have contributed to a better understanding of plant-microbial interactions in the context of biological invasions. By drawing insights from various case studies, I illustrate how next-generation sequencing (DNA barcoding) has revolutionized the way we understand such interactions. Tight-knit and coevolved mutualist (e.g. mycorrhizal) and antagonist (e.g. pathogen) interactions appear particularly promising to understand the structure and function of invasive plant-microbial interaction networks, the impacts of invasive plants on native networks and the vulnerability of native networks to infiltration by non-native species. I also discuss novel ways in which molecular data can aid the study of invasive plant-microbial interactions, such as incorporating phylogenetic data into network analyses to better understand the role of evolutionary history in network dynamics and how such dynamics respond to plant invasions. DNA barcoding of microbes also presents unique challenges to the study of network ecology, such as uncertainty in the legitimacy and efficiency of interactions. Future research should incorporate overall plant-associated microbial communities (microbiomes) into interaction networks to better understand the role microbes play during plant invasions.

scholarly journals Natural Products as Gastroprotective and Antiulcer Agents: Recent Developments

2008 ◽  
Vol 3 (12) ◽  
pp. 1934578X0800301 ◽  
Author(s):  
Rosa Tundis ◽  
Monica R Loizzo ◽  
Marco Bonesi ◽  
Federica Menichini ◽  
FilomenaConforti ◽  
...  
Keyword(s):  
Natural Products ◽  
Current Knowledge ◽  
Gastrointestinal Diseases ◽  
Chronic Inflammatory Disease ◽  
Future Perspectives ◽  
Duodenal Ulcers ◽  
Antiulcer Agents ◽  
Alternative Drug ◽  
Recent Developments ◽  
Upper Gastrointestinal

Peptic ulcer, one of the most common gastrointestinal diseases, is a chronic inflammatory disease characterized by ulceration in the regions of the upper gastrointestinal tract where parietal cells are found and where they secrete hydrochloric acid and pepsin. The anatomical sites where ulcer occurs commonly are stomach and duodenum, causing gastric and duodenal ulcer, respectively. Physiopathology of ulcer is due to an imbalance between aggressive factors, such as acid, pepsin, Helicobacter pylori and non-steroidal anti-inflammatory agents, and local mucosal defensive factors, such as mucus bicarbonate, blood flow and prostaglandins. Several drugs are widely used to prevent or treat gastro-duodenal ulcers. These include H2-receptor antagonists, proton pump inhibitors and cytoprotectives. Due to problems associated with recurrence after treatment, there is therefore the need to seek alternative drug sources against ulcers. In recent years, a widespread search has been launched to identify new gastroprotective drugs from natural sources. The aim of the present review is to highlight the recent advances in current knowledge on natural products as gastroprotective and antiulcer agents and consider the future perspectives for the use of these compounds.

scholarly journals Pexophagy: The Selective Degradation of Peroxisomes

2012 ◽  
Vol 2012 ◽  
pp. 1-18 ◽  
Author(s):  
Andreas Till ◽  
Ronak Lakhani ◽  
Sarah F. Burnett ◽  
Suresh Subramani
Keyword(s):  
Mammalian Cells ◽  
Current Knowledge ◽  
Cell Types ◽  
Model Systems ◽  
Eukaryotic Cells ◽  
Organelle Biogenesis ◽  
Selective Degradation ◽  
Future Challenges ◽  
Recent Developments ◽  
Distinct Features

Peroxisomes are single-membrane-bounded organelles present in the majority of eukaryotic cells. Despite the existence of great diversity among different species, cell types, and under different environmental conditions, peroxisomes contain enzymes involved inβ-oxidation of fatty acids and the generation, as well as detoxification, of hydrogen peroxide. The exigency of all eukaryotic cells to quickly adapt to different environmental factors requires the ability to precisely and efficiently control peroxisome number and functionality. Peroxisome homeostasis is achieved by the counterbalance between organelle biogenesis and degradation. The selective degradation of superfluous or damaged peroxisomes is facilitated by several tightly regulated pathways. The most prominent peroxisome degradation system uses components of the general autophagy core machinery and is therefore referred to as “pexophagy.” In this paper we focus on recent developments in pexophagy and provide an overview of current knowledge and future challenges in the field. We compare different modes of pexophagy and mention shared and distinct features of pexophagy in yeast model systems, mammalian cells, and other organisms.

Traitement de l'air par biofiltration

1999 ◽  
Vol 26 (4) ◽  
pp. 402-424 ◽  
Author(s):  
Hasnaa Jorio ◽  
Michèle Heitz
Keyword(s):  
Current Knowledge ◽  
Industrial Applications ◽  
Biological Processes ◽  
Environmental Aspects ◽  
Basic Principles ◽  
Operational Conditions ◽  
Volatile Organic ◽  
Recent Developments ◽  
Treatment Technologies ◽  
Expensive Process

During several decades, there have been numerous studies and attempts in the field of the treatment of volatile organic solvent contaminated air, with the aim of finding a more efficient and less expensive process. In parallel with the traditional air treatment technologies, biological processes have emerged in recent years. Biofiltration appears to be a particularly preferred path due to its efficiency, its environmental aspects, and its lower costs. In this paper, the biofiltration technology is positioned in relation to conventional techniques and other biological air treatments. Subsequently, after a short historical account of biofiltration, the focus is put on the main objective of this literature review, presenting the current knowledge about the basic principles of the process, its applicability, operational conditions that influence performance and reliability of this process, and recent developments in mathematical biofilter modeling. Finally, industrial applications and biofiltration processing costs are briefly discussed.Key words: biofilter, VOC, biodegradation, modeling, kinetics, humidity, temperature, pH, nutrients, oxygen.[Journal translation]

Defense peptides: recent developments

2015 ◽  
Vol 6 (4) ◽  
pp. 237-251 ◽  
Author(s):  
Małgorzata Cytryńska ◽  
Agnieszka Zdybicka-Barabas
Keyword(s):  
De Novo ◽  
Current Knowledge ◽  
Membrane Lipid ◽  
Factors Affecting ◽  
Natural Defense ◽  
Secreted Factors ◽  
Recent Developments ◽  
Extracellular Proteinases ◽  
Defense Peptides ◽  
Conventional Antibiotics

AbstractDefense peptides are small amphipathic molecules that exhibit antimicrobial, antitumor, antiviral, and immunomodulatory properties. This review summarizes current knowledge on the mechanisms of antimicrobial activity of cationic and anionic defense peptides, indicating peptide-based as well as microbial cell-based factors affecting this activity. The peptide-based factors include charge, hydrophibicity, and amphipathicity, whereas the pathogen-based factors are membrane lipid composition, presence of sterols, membrane fluidity, cell wall components, and secreted factors such as extracellular proteinases. Since defense peptides have been considered very promising molecules that could replace conventional antibiotics in the era of drug-resistant pathogens, the issue of microbial resistance to antimicrobial peptides (AMPs) is addressed. Furthermore, selected approaches employed for optimization and de novo design of effective AMPs based on the properties recognized as important for the function of natural defense peptides are presented.

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