A Novel and Cost Effective Isatin Based Schiff Base Fluorophore: Highly Efficient “Turn-Off” Fluorescent Sensor for the Selective Detection of Cysteine in Aqueous Medium

2021 ◽  
Author(s):  
SAVITHA D P ◽  
Deepa Sebastian ◽  
Anjali Krishna G ◽  
P. V. Mohanan
Keyword(s):  
Mass Spectrometry ◽  
Schiff Base ◽  
Aqueous Medium ◽  
13C Nmr ◽  
Schiff Base Ligand ◽  
Fluorescent Sensor ◽  
Cost Effective ◽  
Spectroscopic Methods ◽  
Selective Detection ◽  
Uv Visible

A novel schiff base ligand 3-(2-Amino-4, 5-dimethyl-phenylimino)-5-phenyl-1, 3-dihydro-indol-2-one (MPD 5MI) and was characterized using spectroscopic methods including UV visible, Infrared, 1H-NMR, 13C-NMR and mass spectrometry. The essential fluorescence properties such...

scholarly journals Some Metal Ions Complexes Derived From Schiff Base Ligand with Anthranillic Acid: Preparation, Spectroscopic and Biological Studies

2020 ◽  
Vol 17 (1) ◽  
pp. 0099
Author(s):  
Lekaa khalid Karem
Keyword(s):  
Schiff Base ◽  
Schiff Base Ligand ◽  
Magnetic Moment ◽  
Primary Amine ◽  
Molar Conductivity ◽  
Spectroscopic Methods ◽  
Geometrical Shape ◽  
Biological Studies ◽  
Different Types ◽  
Uv Visible

This search includes the preparation of Schiff base ligand (SB) from condensation primary amine with vanillin. The new ligand was diagnosed by spectroscopic methods as Mass, NMR, CHN and FTIR. Ligand complexes were mixed from new (SB) and Anthranillic acid (A) with five metal (II) chlorides. The preparation and diagnosis were conducted by FTIR, CHN, UV-visible, molar conductivity, atomic absorption and magnetic moment. The octahedral geometrical shape of the complexes was proposed. The ligands and their new complexes were screened with two different types of bacteria.

scholarly journals Mechanochemical Synthesis and Potentiation of the Antimicrobial Activity of 4-[3-(4-methoxyphenyl)-allylideneamino]-1,5-dimethyl-2-phenylpyrazol-3-one by Metal Chelation

2020 ◽  
Vol 8 (2) ◽  
pp. 15-21
Author(s):  
Onyinye Chinelo Aguzue ◽  
Adebiyi Adedayo ◽  
Oviawe Amowie Phillip
Keyword(s):  
Antimicrobial Activity ◽  
Schiff Base ◽  
13C Nmr ◽  
Schiff Base Ligand ◽  
Binding Sites ◽  
Divalent Metal ◽  
Metal Chelation ◽  
Uv Visible ◽  
Divalent Metal Complexes ◽  
Low Activity

A Schiff base ligand, 4-[3-(4-methoxyphenyl)-allylideneamino]-1,5-dimethyl-2-phenylpyrazol-3-one has been synthesized by the condensation of Methoxycinnamaldehyde and 4-aminoantipyrine. Its divalent metal complexes of Co, Ni, and Cu were also synthesized using the mechanochemical solvent-free method. The ligand and the complexes were characterized by FTIR, UV/visible, 1H NMR, 13C NMR, and GC-MS. The ligand behaved as a bidentate donor by using its carbonyl and azomethine N as binding sites for the metals. The ligand showed low activity against some microbes but the complexes were remarkably active against the fungi species.

scholarly journals A Novel Thiosemicarbazide-Based Fluorescent Chemosensor for Hypochlorite in Near-Perfect Aqueous Solution and Zebrafish

Chemosensors ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 65
Author(s):  
Minji Lee ◽  
Donghwan Choe ◽  
Soyoung Park ◽  
Hyeongjin Kim ◽  
Soomin Jeong ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Reactive Oxygen Species ◽  
Aqueous Solution ◽  
Fluorescence Quenching ◽  
Limit Of Detection ◽  
Fluorescent Sensor ◽  
Ionization Mass ◽  
Oxygen Species ◽  
Marked Selectivity ◽  
Uv Visible

A novel thiosemicarbazide-based fluorescent sensor (AFC) was developed. It was successfully applied to detect hypochlorite (ClO−) with fluorescence quenching in bis-tris buffer. The limit of detection of AFC for ClO− was analyzed to be 58.7 μM. Importantly, AFC could be employed as an efficient and practical fluorescent sensor for ClO− in water sample and zebrafish. Moreover, AFC showed a marked selectivity to ClO− over varied competitive analytes with reactive oxygen species. The detection process of AFC to ClO− was illustrated by UV–visible and fluorescent spectroscopy and electrospray ionization–mass spectrometry (ESI–MS).

scholarly journals A Novel DNA and Dengue Virus Protein Binding of Antipyridine Based Copper and Zinc Metal Complexes through Molecular Docking Studies

2019 ◽  
Vol 31 (8) ◽  
pp. 1733-1736
Author(s):  
K.N. Gita ◽  
V. Chandrasekaran ◽  
P. Akilan
Keyword(s):  
Mass Spectrometry ◽  
Schiff Base ◽  
Binding Energy ◽  
Metal Complexes ◽  
Schiff Base Ligand ◽  
Grid Point ◽  
Docking Studies ◽  
Virus Protein ◽  
Human Dna ◽  
Ns3 Protease

The Cu(II) and Zn(II) complexes were synthesized using Schiff base ligand by refluxing with CuCl2 and ZnCl2. A Schiff base ligand (L) was synthesized by condensing o-vanillin and 4-aminoantipyrine. The synthesized ligand and metal complexes were characterized by IR and mass spectrometry. The synthesized Cu(II) and Zn(II) metal complexes were especially docked with human DNA (PDB I.D: 1BNA) and dengue protein virus (PDB ID: 2VBC) using auto dock software tools version 1.5.6 and pymol. The binding of the ligand and biomolecule in grid point value of x × y × z directions of 90 × 90 × 90 and a grid space group value of 0.380 Å. The binding energy values of Cu(II) and Zn(II) complexes were respectively -7.1 and -7.4 kcal mol–1 towards NS3 protease-helicase, while the binding energy values of Cu(II) and Zn(II) complexes were found to be -8.5 and -8.2 kcal mol–1, respectively towards B-DNA.

scholarly journals Metal-Based Scaffolds of Schiff Bases Derived from Naproxen: Synthesis, Antibacterial Activities, and Molecular Docking Studies

Molecules ◽  
2019 ◽  
Vol 24 (7) ◽  
pp. 1237 ◽  
Author(s):  
Muhammad Shaheen ◽  
Shanshan Feng ◽  
Mehwish Anthony ◽  
Muhammad Tahir ◽  
Mubashir Hassan ◽  
...  
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Base Ligand ◽  
Antibacterial Activities ◽  
Docking Studies ◽  
Computational Docking ◽  
Square Planar ◽  
Uv Visible ◽  
Xrd Techniques ◽  
Bioactivity Profile

We report here the synthesis, characterization, and antibacterial evaluation of transition metal complexes of Ni, Cu, Co, Mn, Zn, and Cd (6a–f), using a Schiff base ligand (5) derived from naproxen (an anti-inflammatory drug) and 5-bromosalicylaldehyde by a series of reactions. The ligand and the synthesized complexes were characterized by elemental analysis, UV-Visible, FTIR, and XRD techniques. The ligand 5 behaves as a bidentate donor and coordinates with metals in square planar or tetrahedral fashion. In order to evaluate its bioactivity profile, we screened the Schiff base ligand and its metal complexes (6a–f) against different species of bacteria and the complexes were found to exhibit significant antibacterial activity. The complexes showed more potency against Bacillus subtilis as compared to the other species. Moreover, we modeled these complexes’ binding affinity against COX1 protein using computational docking.

Aggregation-induced emissive pyridoxal derived tetradentate Schiff base for the fluorescent turn-off sensing of copper(II) in aqueous medium

2022 ◽  
Author(s):  
Vinita Bhardwaj ◽  
Lavani Hindocha ◽  
S. K. Ashokkumar ◽  
Suban K Sahoo
Keyword(s):  
Schiff Base ◽  
Aqueous Medium ◽  
Schiff Base Ligand ◽  
Aggregation Induced Emission ◽  
Tetradentate Schiff Base

In this study, a tetradentate Schiff base ligand L was synthesized by condensing o-phenylenediamine with two moles of pyridoxal. The solution of L in EtOH/DMSO showed aggregation-induced emission (AIE) behaviour...

"Applications of biological of Azo-Schiff base ligand and its metal complexes and: A review "

2021 ◽  
Vol 8 (1) ◽  
pp. 74-80
Author(s):  
Lamia S. Ashoor ◽  
Rawa’a Abass Majeed ◽  
Rehab K. R. Al-Shemary
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Cancer Cells ◽  
Aqueous Medium ◽  
Schiff Bases ◽  
Schiff Base Ligand ◽  
Unique Feature ◽  
Biological Structures

"1998 onwards, a span reporting 1000s of studies depicts the ever-increasing Schiff bases and their complexes applicability; this study genetically tests the research of the last 20 years. The variety of these molecules structural has made them obtainable for a so broad ambit for implementations of biological. They are eminent and because of this unique feature they find their position in the quantitative and qualitative calculation of metals in the aqueous medium. It demonstrated to be prominent catalysts and showed an enjoyable effect of fluorescence. Definitively, Schiff base fissures gotten situation of a unique during bio-experiments and in vitro to develop drugs with a large number of biological structures containing parasites, fungi, viruses, cancer cells, bacteria, etc.

Dual sensing of methionine and aspartic acid in aqueous medium by quinoline based fluorescent probe

2021 ◽  
Author(s):  
Elamathi Chennakrishnan ◽  
R. J. Butcher ◽  
Mohankumar Amirthalingam ◽  
Palanisamy Sundararaj ◽  
Kuppanagounder Elango ◽  
...  
Keyword(s):  
Schiff Base ◽  
Aqueous Medium ◽  
Fluorescent Probe ◽  
Aspartic Acid ◽  
Copper Ion ◽  
Selective Detection ◽  
Dual Sensing

Quinoline based Schiff base 6-methyl-2-oxo-1,2-dihydro-quinoline-3carboxaldehyde-4(N)-phenylsemicarbazone (6MPS) sensor has been developed for selective sensing of methionine and aspartic acid in aqueous medium through selective detection of copper ion as “on-off-on” type....

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