Ultratrace level detection of Cu2+ in aqueous medium by novel Zn(II)-dicarboxylato – pyridyl coordination polymers and cell imaging with HepG2 cells

2021 ◽  
Author(s):  
Suprava Bhunia ◽  
Basudeb Dutta ◽  
Kunal Pal ◽  
Angeera Chandra ◽  
Kuladip Jana ◽  
...  
Keyword(s):  
Dicarboxylic Acid ◽  
Aqueous Medium ◽  
Coordination Polymers ◽  
Hepg2 Cells ◽  
Cell Imaging ◽  
Muconic Acid

Two newly designed coordination polymers (CPs), [Zn(adc)(4-Cltpy)(H2O)] (CP1) and [Zn(trans-muca)(4-Cltpy)] (CP2) (4-Cltpy = 4′-Chloro-2,2′:6′,2′′-terpyridine, H2adc = Acetylene- dicarboxylic acid, trans-H2muca = trans, trans-muconic acid) are synthesized and structurally characterized by...

I2 catalyzed access of spiro[indoline-3,4′-pyridine] appended amine dyad: new ON–OFF chemosensors for Cu2+ and imaging in living cells

2018 ◽  
Vol 16 (2) ◽  
pp. 302-315 ◽  
Author(s):  
Animesh Mondal ◽  
Barnali Naskar ◽  
Sanchita Goswami ◽  
Chandraday Prodhan ◽  
Keya Chaudhuri ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Hepg2 Cells ◽  
Cell Imaging ◽  
Colorimetric Detection ◽  
Living Cells ◽  
Fluorescent Cell

An efficient, easily tuneable route to construct a structurally diverse organic fluorescent probe and its applications towards the colorimetric detection of Cu2+ ions and in vitro fluorescent cell imaging of Cu2+ in HepG2 cells.

Two- and three-dimensional coordination polymers based on zinc(II) and furan-2,5-dicarboxylic acid: structure variation due to metal-to-linker ratio

2018 ◽  
Vol 74 (12) ◽  
pp. 1719-1724 ◽  
Author(s):  
Yimin Mao ◽  
Peter Y. Zavalij
Keyword(s):  
Dicarboxylic Acid ◽  
Coordination Polymers ◽  
Three Dimensional ◽  
Molar Ratio ◽  
Monoclinic Space Group ◽  
Structure Variation ◽  
Space Group ◽  
Hydrogen Bonding Pattern ◽  
Solvent Molecules ◽  
A Chain

Two ZnII-based coordination polymers (CPs) were synthesized by the hydrothermal method, using Zn(NO3)2·6H2O and furan-2,5-dicarboxylic acid (FDCA) in dimethylformamide (DMF) solvent, at 95 °C. Poly[tetrakis(dimethylazanium) [tetrakis(μ2-furan-2,5-dicarboxylato-κ2 O 2:O 5)dizinc(II)]], {(C2H8N)4[Zn2(C6H2O5)4]} n or {[DMA]4[ZnII 2(FDC)4]} n (DMA = dimethylazanium and FDC = furan-2,5-dicarboxylate), (1), was obtained with a 1:1 molar ratio of ZnII and FDCA. It crystallized in the monoclinic space group C2/c. Coordinated by ZnII ions, FDC2− ligands form 21 double-stranded helices propagating along the b axis. The helices are interconnected and extend laterally in the a direction, forming a two-dimensional (2D) sheet-like network. The 2D sheets are stacked along the c direction without interconnections. DMA cations are cocrystallized in (1) and are hydrogen bonded with carboxylate O atoms of the FDC2− ligands. The hydrogen-bonding pattern consists of R 2 2(4) and R 2 2(10) motifs alternating in a chain. Poly[bis(dimethylazanium) [bis(μ4-furan-2,5-dicarboxylato-κO 2:κO 2′:κO 5:κO 5)bis(μ3-furan-2,5-dicarboxylato-κO 2:κO 2′:κO 5)dizinc(II)] dimethylformamide 3.08-solvate], {(C2H8N)2[Zn2(C6H2O5)4]·3.08C3H7NO} n or {[DMA]2[ZnII 3(FDC)4]·3.08DMF} n , (2), was obtained with a 1:2 molar ratio of ZnII and FDCA. It crystallized in the monoclinic space group P21/c, forming a three-dimensional network. The pores are filled with DMA cations and DMF solvent molecules.

TIPA-based luminescent Cd(II) organic frameworks as an outingstanding sensor for detecting Fe3+ in aqueous medium

CrystEngComm ◽  
2021 ◽  
Author(s):  
Jianling Ni ◽  
Yu Liang ◽  
Juan-Juan Shao ◽  
Jun-Feng Li ◽  
Guang-Jun Li ◽  
...  
Keyword(s):  
Dicarboxylic Acid ◽  
Aqueous Medium

Two new title MOFs, [Cd2(TIPA)2(bpodc)2]n (1 or MOF-1), [Cd2(TIPA)2(oba)2]n (2 or MOF-2) (TIPA = tris(4-(1H-imidazol-1- yl)phenyl)amine, bpodc = benzophenone-4,4'- dicarboxylic acid, oba = 4,4’-oxydibenzoic acid ) have been synthesized by...

scholarly journals Lipolytic Effects of 3-Iodothyronamine (T1AM) and a Novel Thyronamine-Like Analog SG-2 through the AMPK Pathway

2019 ◽  
Vol 20 (16) ◽  
pp. 4054 ◽  
Author(s):  
Michael Rogowski ◽  
Lorenza Bellusci ◽  
Martina Sabatini ◽  
Simona Rapposelli ◽  
Shaikh M. Rahman ◽  
...  
Keyword(s):  
Lipid Accumulation ◽  
Hepg2 Cells ◽  
Low Dose ◽  
Cell Imaging ◽  
Culture Media ◽  
Lipolytic Activity ◽  
Metabolic Reprogramming ◽  
Synthetic Analog ◽  
Site Of Action ◽  
Mouse Adipocytes

3-Iodothyronamine (T1AM) and its synthetic analog SG-2 are rapidly emerging as promising drivers of cellular metabolic reprogramming. Our recent research indicates that in obese mice a sub-chronic low dose T1AM treatment increased lipolysis, associated with significant weight loss independent of food consumption. The specific cellular mechanism of T1AM’s lipolytic effect and its site of action remains unknown. First, to study the mechanism used by T1AM to gain entry into cells, we synthesized a fluoro-labeled version of T1AM (FL-T1AM) by conjugating it to rhodamine (TRITC) and analyzed its cellular uptake and localization in 3T3-L1 mouse adipocytes. Cell imaging using confocal microscopy revealed a rapid intercellular uptake of FL-T1AM into mitochondria without localization to the lipid droplet or nucleus of mature adipocytes. Treatment of 3T3-L1 adipocytes with T1AM and SG-2 resulted in decreased lipid accumulation, the latter showing a significantly higher potency than T1AM (10 µM vs. 20 µM, respectively). We further examined the effects of T1AM and SG-2 on liver HepG2 cells. A significant decrease in lipid accumulation was observed in HepG2 cells treated with T1AM or SG-2, due to increased lipolytic activity. This was confirmed by accumulation of glycerol in the culture media and through activation of the AMPK/ACC signaling pathways.

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