scholarly journals Assessing the parameters modulating optical losses of iron oxide nanoparticles under near infrared irradiation

2021 ◽  
Author(s):  
Claudia Lozano-Pedraza ◽  
Elena Plaza-Mayoral ◽  
Ana Espinosa ◽  
Begoña Sot ◽  
Aida Serrano ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Near Infrared ◽  
Optical Loss ◽  
Oxide Nanoparticles ◽  
Infrared Irradiation ◽  
Optical Losses

Heating mediated by iron oxide nanoparticles subjected to near infrared irradiation has recently gained lots of interest. The high optical loss values reported in combination with the optical technologies already...

Preparation of magnetized iron oxide grafted on graphene oxide for hyperthermia application

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Ahmad Abulfathi Umar ◽  
Muhamad Fazly Abdul Patah ◽  
Faisal Abnisa ◽  
Wan Mohd Ashri Wan Daud
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Near Infrared ◽  
Malignant Tumors ◽  
Synthesis Method ◽  
Therapeutic Modality ◽  
Iron Oxide Nanoparticle ◽  
Oxide Nanoparticles ◽  
Hybrid Nanostructure ◽  
Characterization Techniques

AbstractMagnetic hyperthermia therapy (MHT) is a highly promising therapeutic modality for the treatment of different kinds of cancers and malignant tumors. The therapy is based on the concept that; iron oxide nanoparticles deposited at cancer sites can generate heat when exposed to an alternating current magnetic field or near infrared radiation and consequently destroying only the cancer cells by exploiting their vulnerability to heat. The fact that the treatment is at molecular level and that iron oxide nanoparticles provide more guided focus heating justifies its efficacy over treatment such as surgery, radiation therapy and chemotherapy. Nevertheless, the spread of MHT as the next-generation therapeutics has been shadowed by insufficient heating especially at the in vivo stage. This can be averted by modifying the iron oxide nanoparticle structure. To this end, various attempts have been made by developing a magnetic hybrid nanostructure capable of generating efficient heat. However, the synthesis method for each component (of the magnetic hybrid nanostructure) and the grafting process is now an issue. This has a direct effect on the performance of the magnetic hybrid nanostructure in MHT and other applications. The main objective of this review is to detail out the different materials, methods and characterization techniques that have been used so far in developing magnetic hybrid nanostructure. In view of this, we conducted a comprehensive review and present a road map for developing a magnetic hybrid nanostructure that is capable of generating optimum heat during MHT. We further summarize the various characterization techniques and necessary parameters to study in validating the efficiency of the magnetic hybrid nanostructure. Hopefully, this contribution will serve as a guide to researchers that are willing to evaluate the properties of their magnetic hybrid nanostructure.

Green synthesis of near-infrared absorbing eugenate capped iron oxide nanoparticles for photothermal application

2019 ◽  
Vol 31 (9) ◽  
pp. 095705 ◽  
Author(s):  
Prashant Kharey ◽  
Surjendu Bikash Dutta ◽  
Manikandan M ◽  
I A Palani ◽  
S K Majumder ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Green Synthesis ◽  
Iron Oxide Nanoparticles ◽  
Near Infrared ◽  
Oxide Nanoparticles

Iron oxide nanoparticles protected by NIR-active multidentate-polymers as multifunctional nanoprobes for NIRF/PA/MR trimodal imaging

Nanoscale ◽  
2016 ◽  
Vol 8 (2) ◽  
pp. 775-779 ◽  
Author(s):  
Yayun Wu ◽  
Duyang Gao ◽  
Pengfei Zhang ◽  
Chuansheng Li ◽  
Qian Wan ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Near Infrared ◽  
Oxide Nanoparticles ◽  
Active Iron

Compact NIR-active iron oxide nanoparticles protected by near-infrared catechol-multidentate polymers for NIRF/PA/MR trimodal imaging.

scholarly journals Methods of Granulocyte Isolation from Human Blood and Labeling with Multimodal Superparamagnetic Iron Oxide Nanoparticles

Molecules ◽  
2020 ◽  
Vol 25 (4) ◽  
pp. 765
Author(s):  
Fernando Alvieri ◽  
Javier B. Mamani ◽  
Mariana P. Nucci ◽  
Fernando A. Oliveira ◽  
Igor S. Filgueiras ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
High Purity ◽  
Near Infrared ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Iron Load ◽  
Nirf Imaging ◽  
Icp Ms

This in vitro study aimed to find the best method of granulocyte isolation for subsequent labeling with multimodal nanoparticles (magnetic and fluorescent properties) to enable detection by optical and magnetic resonance imaging (MRI) techniques. The granulocytes were obtained from venous blood samples from 12 healthy volunteers. To achieve high purity and yield, four different methods of granulocyte isolation were evaluated. The isolated granulocytes were labeled with multimodal superparamagnetic iron oxide nanoparticles (M-SPIONs) coated with dextran, and the iron load was evaluated qualitatively and quantitatively by MRI, near-infrared fluorescence (NIRF) and inductively coupled plasma mass spectrometry (ICP-MS). The best method of granulocyte isolation was Percoll with Ficoll, which showed 95.92% purity and 94% viability. After labeling with M-SPIONs, the granulocytes showed 98.0% purity with a yield of 3.5 × 106 cells/mL and more than 98.6% viability. The iron-loading value in the labeled granulocytes, as obtained by MRI, was 6.40 ± 0.18 pg/cell. Similar values were found with the ICP-MS and NIRF imaging techniques. Therefore, our study shows that it is possible to isolate granulocytes with high purity and yield and labeling with M-SPIONs provides a high internalized iron load and low toxicity to cells. Therefore, these M-SPION-labeled granulocytes could be a promising candidate for future use in inflammation/infection detection by optical and MRI techniques.

scholarly journals Pharmacokinetics of Single Domain Antibodies and Conjugated Nanoparticles Using a Hybrid near Infrared Method

2021 ◽  
Vol 22 (16) ◽  
pp. 8695
Author(s):  
Shiran Su ◽  
Thomas J. Esparza ◽  
Duong Nguyen ◽  
Simone Mastrogiacomo ◽  
Joong H. Kim ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Contrast Agents ◽  
Iron Oxide Nanoparticles ◽  
Near Infrared ◽  
Brain Mri ◽  
Single Domain ◽  
Oxide Nanoparticles ◽  
Nir Imaging ◽  
Single Domain Antibodies ◽  
Molecular Contrast

Iron oxide nanoparticles and single domain antibodies from camelids (VHHs) have been increasingly recognized for their potential uses for medical diagnosis and treatment. However, there have been relatively few detailed characterizations of their pharmacokinetics (PK). The aim of this study was to develop imaging methods and pharmacokinetic models to aid the future development of a novel family of brain MRI molecular contrast agents. An efficient near-infrared (NIR) imaging method was established to monitor VHH and VHH conjugated nanoparticle kinetics in mice using a hybrid approach: kinetics in blood were assessed by direct sampling, and kinetics in kidney, liver, and brain were assessed by serial in vivo NIR imaging. These studies were performed under “basal” circumstances in which the VHH constructs and VHH-conjugated nanoparticles do not substantially interact with targets nor cross the blood brain barrier. Using this approach, we constructed a five-compartment PK model that fits the data well for single VHHs, engineered VHH trimers, and iron oxide nanoparticles conjugated to VHH trimers. The establishment of the feasibility of these methods lays a foundation for future PK studies of candidate brain MRI molecular contrast agents.

scholarly journals Growth of textured thin Au coatings on iron oxide nanoparticles with near infrared absorbance

2012 ◽  
Vol 24 (2) ◽  
pp. 025606 ◽  
Author(s):  
L L Ma ◽  
A U Borwankar ◽  
B W Willsey ◽  
K Y Yoon ◽  
J O Tam ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Near Infrared ◽  
Oxide Nanoparticles

scholarly journals A Novel Dual Fluorochrome Near-Infrared Imaging Probe for Potential Alzheimer’s Enzyme Biomarkers-BACE1 and Cathepsin D

Molecules ◽  
2020 ◽  
Vol 25 (2) ◽  
pp. 274
Author(s):  
Jenny M. Tam ◽  
Lee Josephson ◽  
Alexander R. Pilozzi ◽  
Xudong Huang
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Cathepsin D ◽  
Cleavage Site ◽  
Near Infrared ◽  
Fold Increase ◽  
Oxide Nanoparticles ◽  
Peptide Substrates ◽  
Imaging Probe ◽  
Swedish Mutation

A molecular imaging probe to fluorescently image the β-site of the amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) and cathepsin D (CatD) enzymes associated with Alzheimer’s disease (AD) was designed and synthesized. This imaging probe was built upon iron oxide nanoparticles (cross-linked dextran iron oxide nanoparticles, or CLIO). Peptide substrates containing a terminal near-infrared fluorochrome (fluorophore emitting at 775 nm for CatD or fluorophore emitting at 669 nm for BACE1) were conjugated to the CLIO nanoparticles. The CatD substrate contained a phenylalanine-phenylalanine cleavage site more specific to CatD than BACE1. The BACE1 substrate contained the sequence surrounding the leucine-asparagine cleavage site of the BACE1 found in the Swedish mutation of APP, which is more specific to BACE1 than CatD. These fluorescently-labeled peptide substrates were then conjugated to the nanoparticle. The nanoparticle probes were purified by gel filtration, and their fluorescence intensities were determined using a fluorescence plate reader. The CatD peptide substrate demonstrated a 15.5-fold increase in fluorescence when incubated with purified CatD enzyme, and the BACE1 substrate exhibited a 31.5-fold increase in fluorescence when incubated with purified BACE1 enzyme. Probe specificity was also demonstrated in the human H4 neuroglioma cells and the H4 cells stably transfected with BACE1 in which the probe monitored enzymatic cleavage. In the H4 and H4-BACE1 cells, BACE1 and active CatD activity increased, an occurrence that was reflected in enzyme expression levels as determined by immunoblotting. These results demonstrate the applicability of this probe for detecting potential Alzheimer’s enzyme biomarkers.

pH-responsive PEG-chitosan/iron oxide hybrid nanoassemblies for low-power assisted PDT/PTT combination therapy

Nanomedicine ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. 1097-1112 ◽  
Author(s):  
Guiyang Zhang ◽  
Huilin Gou ◽  
Yanfeng Liu ◽  
Kai Xi ◽  
Dechen Jiang ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Combination Therapy ◽  
Low Power ◽  
Iron Oxide Nanoparticles ◽  
Near Infrared ◽  
Oxide Nanoparticles ◽  
Treatment Efficiency ◽  
High Tendency ◽  
Normal Tissues ◽  
Self Assembling

Aim: To develop a hybrid nanoassembly platform using PEG-chitosan/iron oxide nanoparticles for effective low-power assisted photodynamic/photothermal combination therapy. Materials & methods: The hybrid nanoassemblies (NAs) were firstly fabricated by self-assembling chitosan and iron oxide nanoparticles, following which their surfaces were modified with polyethylene glycolated triphenylphosphine and loaded with methylene blue (MB) photosensitizer. The physical characteristics and phototherapy effects of these NAs were evaluated. Results: The formed MB-loaded NAs could produce both heat and singlet oxygen under low-power near-infrared irradiation, which would damage the cancer cells. Delivered by intravenous injection, the MB-loaded NAs showed high tendency to accumulate at the tumor sites, which would lead to effective cancer treatment under controlled photoexcitation without damaging the normal tissues. Conclusion: The proposed low-power assisted simultaneous photodynamic/photothermal approach effectively improves treatment efficiency and provides safe and precise treatment option.

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