scholarly journals An in situ Gelling BMSC-laden Collagen/Silk Fibroin Double Network Hydrogel for Cartilage Regeneration

2021 ◽  
Author(s):  
Yajie Zhang ◽  
Min Liu ◽  
Renjun Pei
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Cartilage Tissue Engineering ◽  
Cartilage Regeneration ◽  
Cartilage Tissue ◽  
Injectable Hydrogels ◽  
Double Network ◽  
Good Biocompatibility ◽  
In Situ Gelling

Collagen (Col)-based injectable hydrogels are desirable scaffolds for cartilage tissue engineering. However, fabrication of Col-based injectable hydrogels with short gelation times, good biocompatibility and high mechanical properties still faces great...

An injectable hydrogel formed by in situ cross-linking of glycol chitosan and multi-benzaldehyde functionalized PEG analogues for cartilage tissue engineering

2015 ◽  
Vol 3 (7) ◽  
pp. 1268-1280 ◽  
Author(s):  
Luping Cao ◽  
Bin Cao ◽  
Chengjiao Lu ◽  
Guowei Wang ◽  
Lin Yu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue ◽  
Cross Linking ◽  
Glycol Chitosan ◽  
Injectable Hydrogels ◽  
Injectable Hydrogel ◽  
Cross Linker ◽  
Aldehyde Groups

A novel PEG analogue, poly(EO-co-Gly)-CHO, that possesses multiple aldehyde groups is designed and synthesized, and then is used as a cross-linker to react with glycol chitosan to create injectable hydrogels.

In situ fabrication of a composite hydrogel with tunable mechanical properties for cartilage tissue engineering

2019 ◽  
Vol 7 (15) ◽  
pp. 2463-2473 ◽  
Author(s):  
Fenbo Ma ◽  
Yongmei Ge ◽  
Nian Liu ◽  
Xiangchao Pang ◽  
Xingyu Shen ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Cartilage Tissue Engineering ◽  
Composite Hydrogel ◽  
Cartilage Tissue ◽  
In Situ Fabrication ◽  
Tunable Mechanical Properties

A composite hydrogel with tunable mechanical properties has been fabricated and characterized in this study.

scholarly journals Digital Light Processing Bioprinted Human Chondrocyte-Laden Poly (γ-Glutamic Acid)/Hyaluronic Acid Bio-Ink towards Cartilage Tissue Engineering

Biomedicines ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 714
Author(s):  
Alvin Kai-Xing Lee ◽  
Yen-Hong Lin ◽  
Chun-Hao Tsai ◽  
Wan-Ting Chang ◽  
Tsung-Li Lin ◽  
...  
Keyword(s):  
United States ◽  
Tissue Engineering ◽  
Hyaluronic Acid ◽  
Glutamic Acid ◽  
Cellular Proliferation ◽  
Cartilage Tissue Engineering ◽  
Cartilage Regeneration ◽  
The United States ◽  
Cartilage Injury ◽  
Cartilage Tissue

Cartilage injury is the main cause of disability in the United States, and it has been projected that cartilage injury caused by osteoarthritis will affect 30% of the entire United States population by the year 2030. In this study, we modified hyaluronic acid (HA) with γ-poly(glutamic) acid (γ-PGA), both of which are common biomaterials used in cartilage engineering, in an attempt to evaluate them for their potential in promoting cartilage regeneration. As seen from the results, γ-PGA-GMA and HA, with glycidyl methacrylate (GMA) as the photo-crosslinker, could be successfully fabricated while retaining the structural characteristics of γ-PGA and HA. In addition, the storage moduli and loss moduli of the hydrogels were consistent throughout the curing durations. However, it was noted that the modification enhanced the mechanical properties, the swelling equilibrium rate, and cellular proliferation, and significantly improved secretion of cartilage regeneration-related proteins such as glycosaminoglycan (GAG) and type II collagen (Col II). The cartilage tissue proof with Alcian blue further demonstrated that the modification of γ-PGA with HA exhibited suitability for cartilage tissue regeneration and displayed potential for future cartilage tissue engineering applications. This study built on the previous works involving HA and further showed that there are unlimited ways to modify various biomaterials in order to further bring cartilage tissue engineering to the next level.

scholarly journals Advanced Hydrogels for Cartilage Tissue Engineering: Recent Progress and Future Directions

Polymers ◽  
2021 ◽  
Vol 13 (23) ◽  
pp. 4199
Author(s):  
Mahshid Hafezi ◽  
Saied Nouri Khorasani ◽  
Mohadeseh Zare ◽  
Rasoul Esmaeely Neisiany ◽  
Pooya Davoodi
Keyword(s):  
Tissue Engineering ◽  
Cartilage Tissue Engineering ◽  
Cartilage Regeneration ◽  
Biomechanical Properties ◽  
Tissue Growth ◽  
Cartilage Tissue ◽  
Self Healing ◽  
Advantages And Disadvantages ◽  
Wide Range

Cartilage is a tension- and load-bearing tissue and has a limited capacity for intrinsic self-healing. While microfracture and arthroplasty are the conventional methods for cartilage repair, these methods are unable to completely heal the damaged tissue. The need to overcome the restrictions of these therapies for cartilage regeneration has expanded the field of cartilage tissue engineering (CTE), in which novel engineering and biological approaches are introduced to accelerate the development of new biomimetic cartilage to replace the injured tissue. Until now, a wide range of hydrogels and cell sources have been employed for CTE to either recapitulate microenvironmental cues during a new tissue growth or to compel the recovery of cartilaginous structures via manipulating biochemical and biomechanical properties of the original tissue. Towards modifying current cartilage treatments, advanced hydrogels have been designed and synthesized in recent years to improve network crosslinking and self-recovery of implanted scaffolds after damage in vivo. This review focused on the recent advances in CTE, especially self-healing hydrogels. The article firstly presents the cartilage tissue, its defects, and treatments. Subsequently, introduces CTE and summarizes the polymeric hydrogels and their advances. Furthermore, characterizations, the advantages, and disadvantages of advanced hydrogels such as multi-materials, IPNs, nanomaterials, and supramolecular are discussed. Afterward, the self-healing hydrogels in CTE, mechanisms, and the physical and chemical methods for the synthesis of such hydrogels for improving the reformation of CTE are introduced. The article then briefly describes the fabrication methods in CTE. Finally, this review presents a conclusion of prevalent challenges and future outlooks for self-healing hydrogels in CTE applications.

Injectable In Situ Self-Cross-Linking Hydrogels Based on Poly(l-glutamic acid) and Alginate for Cartilage Tissue Engineering

2014 ◽  
Vol 15 (12) ◽  
pp. 4495-4508 ◽  
Author(s):  
Shifeng Yan ◽  
Taotao Wang ◽  
Long Feng ◽  
Jie Zhu ◽  
Kunxi Zhang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Glutamic Acid ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue ◽  
Cross Linking

Enzymatically-crosslinked injectable hydrogels based on biomimetic dextran–hyaluronic acid conjugates for cartilage tissue engineering

Biomaterials ◽  
2010 ◽  
Vol 31 (11) ◽  
pp. 3103-3113 ◽  
Author(s):  
R. Jin ◽  
L.S. Moreira Teixeira ◽  
P.J. Dijkstra ◽  
C.A. van Blitterswijk ◽  
M. Karperien ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Hyaluronic Acid ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue ◽  
Injectable Hydrogels

scholarly journals Gellan Gum Injectable Hydrogels for Cartilage Tissue Engineering Applications: In Vitro Studies and Preliminary In Vivo Evaluation

2010 ◽  
Vol 16 (1) ◽  
pp. 343-353 ◽  
Author(s):  
João T. Oliveira ◽  
Tírcia C. Santos ◽  
Luís Martins ◽  
Ricardo Picciochi ◽  
Alexandra P. Marques ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cartilage Tissue Engineering ◽  
Gellan Gum ◽  
In Vitro Studies ◽  
Cartilage Tissue ◽  
Engineering Applications ◽  
In Vivo Evaluation ◽  
Injectable Hydrogels

Methylsulfonylmethane-loaded electrospun poly(lactide-co-glycolide) mats for cartilage tissue engineering

RSC Advances ◽  
2015 ◽  
Vol 5 (117) ◽  
pp. 96725-96732 ◽  
Author(s):  
Zongliang Wang ◽  
Yu Wang ◽  
Peibiao Zhang ◽  
Xuesi Chen
Keyword(s):  
Tissue Engineering ◽  
Cartilage Tissue Engineering ◽  
Cartilage Regeneration ◽  
Cartilage Tissue ◽  
Promising Candidate

The electrospun MSM-loaded PLGA mat is a promising candidate for cartilage regeneration.

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