In situ fabrication of a composite hydrogel with tunable mechanical properties for cartilage tissue engineering

2019 ◽  
Vol 7 (15) ◽  
pp. 2463-2473 ◽  
Author(s):  
Fenbo Ma ◽  
Yongmei Ge ◽  
Nian Liu ◽  
Xiangchao Pang ◽  
Xingyu Shen ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Cartilage Tissue Engineering ◽  
Composite Hydrogel ◽  
Cartilage Tissue ◽  
In Situ Fabrication ◽  
Tunable Mechanical Properties

A composite hydrogel with tunable mechanical properties has been fabricated and characterized in this study.

scholarly journals An in situ Gelling BMSC-laden Collagen/Silk Fibroin Double Network Hydrogel for Cartilage Regeneration

2021 ◽  
Author(s):  
Yajie Zhang ◽  
Min Liu ◽  
Renjun Pei
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Cartilage Tissue Engineering ◽  
Cartilage Regeneration ◽  
Cartilage Tissue ◽  
Injectable Hydrogels ◽  
Double Network ◽  
Good Biocompatibility ◽  
In Situ Gelling

Collagen (Col)-based injectable hydrogels are desirable scaffolds for cartilage tissue engineering. However, fabrication of Col-based injectable hydrogels with short gelation times, good biocompatibility and high mechanical properties still faces great...

Injectable In Situ Self-Cross-Linking Hydrogels Based on Poly(l-glutamic acid) and Alginate for Cartilage Tissue Engineering

2014 ◽  
Vol 15 (12) ◽  
pp. 4495-4508 ◽  
Author(s):  
Shifeng Yan ◽  
Taotao Wang ◽  
Long Feng ◽  
Jie Zhu ◽  
Kunxi Zhang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Glutamic Acid ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue ◽  
Cross Linking

Polyethylene glycol diacrylate scaffold filled with cell-laden methacrylamide gelatin/alginate hydrogels used for cartilage repair

2021 ◽  
pp. 088532822110448
Author(s):  
Xiang Zhang ◽  
Zhenhao Yan ◽  
Guotao Guan ◽  
Zijing Lu ◽  
Shujie Yan ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Polyethylene Glycol ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue ◽  
High Concentration ◽  
Polyethylene Glycol Diacrylate ◽  
Low Concentration ◽  
Glycol Diacrylate

Natural cartilage tissue has excellent mechanical properties and has certain cellular components. At this stage, it is a great challenge to produce cartilage scaffolds with excellent mechanical properties, biocompatibility, and biodegradability. Hydrogels are commonly used in tissue engineering because of their excellent biocompatibility; however, the mechanical properties of commonly used hydrogels are difficult to meet the requirements of making cartilage scaffolds. The mechanical properties of high concentration polyethylene glycol diacrylate (PEGDA) hydrogel are similar to those of natural cartilage, but its biocompatibility is poor. Low concentration hydrogel has better biocompatibility, but its mechanical properties are poor. In this study, two different hydrogels were combined to produce cartilage scaffolds with good mechanical properties and strong biocompatibility. First, the PEGDA grid scaffold was printed with light curing 3D printing technology, and then the low concentration GelMA/Alginate hydrogel with chondral cells was filled into the PEGDA grid scaffold. After a series of cell experiments, the filling hydrogel with the best biocompatibility was screened out, and finally the filled hydrogel with cells and excellent biocompatibility was obtained. Cartilage tissue engineering scaffolds with certain mechanical properties were found to have a tendency of cartilage formation in in vitro culture. Compared with the scaffold obtained by using a single hydrogel, this molding method can produce a tissue engineering scaffold with excellent mechanical properties on the premise of ensuring biocompatibility, which has a certain potential application value in the field of cartilage tissue engineering.

Injectable in situ-forming hydrogel for cartilage tissue engineering

2013 ◽  
Vol 1 (26) ◽  
pp. 3314 ◽  
Author(s):  
Jin Seon Kwon ◽  
So Mi Yoon ◽  
Doo Yeon Kwon ◽  
Da Yeon Kim ◽  
Guo Zhe Tai ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue ◽  
In Situ Forming
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