Membrane Integration into PDMS-free Microfluidic Platforms for Organ-on-Chip and Analytical Chemistry Applications

Lab on a Chip ◽  
2021 ◽  
Author(s):  
Stefan Schneider ◽  
Denise Gruner ◽  
Andreas Richter ◽  
Peter Loskill
Keyword(s):  
Analytical Chemistry ◽  
Crucial Role ◽  
Microfluidic Systems ◽  
Microfluidic Platforms ◽  
Research Fields ◽  
On Chip ◽  
Robust Integration

Membranes play a crucial role in many microfluidic systems, enabling versatile applications in highly diverse research fields. However, the tight and robust integration of membranes into microfluidic systems requires complex...

On-chip anticancer drug screening – Recent progress in microfluidic platforms to address challenges in chemotherapy

2019 ◽  
Vol 137 ◽  
pp. 236-254 ◽  
Author(s):  
Nandini Dhiman ◽  
Peter Kingshott ◽  
Huseyin Sumer ◽  
Chandra S. Sharma ◽  
Subha Narayan Rath
Keyword(s):  
Anticancer Drug ◽  
Drug Screening ◽  
Recent Progress ◽  
Microfluidic Platforms ◽  
On Chip

scholarly journals António Ferreira da Silva and the Teaching of Chemistry at the Academia Politécnica do Porto (1877–1910)

2019 ◽  
Vol 20 ◽  
pp. 213-221 ◽  
Author(s):  
José Ferraz-Caetano ◽  
João Paiva ◽  
Francisco Malta Romeiras
Keyword(s):  
Public Health ◽  
Analytical Chemistry ◽  
Nineteenth Century ◽  
Health Education ◽  
Crucial Role ◽  
Public Health Education ◽  
Scientific Education ◽  
Definition Of ◽  
Practical Teaching

Resumo No final do século XIX, a química ganhou notoriedade como uma das principais “ciências ao serviço” da nação. O surgimento de novos tópicos, métodos e práticas úteis contribuíram para a valorização da química e para a definição de medidas governamentais em temas como saúde pública, educação e proteção ambiental. Lente na Academia Politécnica do Porto entre 1877 e 1910, António Ferreira da Silva (1853–1923) desempenhou um papel central na modernização do ensino e da investigação em química em Portugal. Ferreira da Silva foi responsável pela introdução de cursos suplementares de química, pela reformulação do ensino prático, e pela elaboração de novos procedimentos e regulamentos de ensino “que em muito engrandeceram a educação científica” em Portugal. Enquanto lente da Academia Politécnica do Porto, Ferreira da Silva privilegiou ainda a articulação entre o Laboratório da Academia e as indústrias nacionais, contribuindo, em larga medida, para emergência da Química Analítica como uma nova disciplina.Palavras-chave: António Ferreira da Silva; Academia Politécnica do Porto; Química Analítica. Abstract By the turn of the nineteenth century, chemistry had become a “science at the service” of the nation. The emergence of useful topics, methods, and practices contributed to the valorization of chemistry and to the definition of new governmental directives on issues such as public health, education and environment. Lecturer at the Academia Politécnica do Porto between 1877 and 1911, António Ferreira da Silva (1853–1923) played a crucial role in the modernization of the teaching and practice of chemistry in Portugal. Ferreira da Silva created new supplementary chemistry courses, reformed the practical teaching of chemistry, and drafted new proceedings and syllabi “that glorified scientific education” in Portugal. As lecturer of the Academia Politécnica do Porto, he made important steps in the establishment of collaborations between the Academia’s Laboratory and national industries, which largely contributed to the emergence of Analytical Chemistry as an autonomous discipline. Keywords: António Ferreira da Silva; Academia Politécnica do Porto; Analytical Chemistry.

Microfluidic Systems in Analytical Chemistry

2017 ◽  
pp. 1-20 ◽  
Author(s):  
Agustina Gómez-Hens ◽  
Juan M. Fernández-Romero
Keyword(s):  
Analytical Chemistry ◽  
Microfluidic Systems

scholarly journals Sequential storage and release of microdroplets

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Zenon Toprakcioglu ◽  
Tuomas P. J. Knowles
Keyword(s):  
Analytical Chemistry ◽  
Continuous Phase ◽  
Chemical Processes ◽  
Computational Simulations ◽  
Droplet Deformation ◽  
Critical Rate ◽  
Storage And Retrieval ◽  
Key Features ◽  
On Chip ◽  
Shed Light

AbstractDroplet microfluidic methods have opened up the possibility of studying a plethora of phenomena ranging from biological to physical or chemical processes at ultra low volumes and high throughput. A key component of such approaches is the ability to trap droplets for observation, and many device architectures for achieving this objective have been developed. A challenge with such approaches is, however, recovering the droplets following their confinement for applications involving further analysis. Here, we present a device capable of generating, confining and releasing microdroplets in a sequential manner. Through a combination of experimental and computational simulations, we shed light on the key features required for successful droplet storage and retrieval. Moreover, we explore the effect of the flow rate of the continuous phase on droplet release, determining that a critical rate is needed to ensure complete droplet deformation through constrictions holding the droplets in place prior to release. Finally, we find that once released, droplets can be retrieved and collected off chip. The ability to generate, store and sequentially release droplets renders such a device particularly promising for future applications where reactions may not only be monitored on-chip, but droplets can also be retrieved for further analysis, facilitating new exploratory avenues in the fields of analytical chemistry and biology.

scholarly journals The Usual Suspects 2019: of Chips, Droplets, Synthesis, and Artificial Cells

Micromachines ◽  
2019 ◽  
Vol 10 (5) ◽  
pp. 285 ◽  
Author(s):  
Christoph Eilenberger ◽  
Sarah Spitz ◽  
Barbara Eva Maria Bachmann ◽  
Eva Kathrin Ehmoser ◽  
Peter Ertl ◽  
...  
Keyword(s):  
Synthetic Biology ◽  
Cell Biology ◽  
Living Cells ◽  
Experimental Models ◽  
Biological Processes ◽  
Microfluidic Systems ◽  
Artificial Cells ◽  
Life Itself ◽  
Reagent Consumption ◽  
On Chip

Synthetic biology aims to understand fundamental biological processes in more detail than possible for actual living cells. Synthetic biology can combat decomposition and build-up of artificial experimental models under precisely controlled and defined environmental and biochemical conditions. Microfluidic systems can provide the tools to improve and refine existing synthetic systems because they allow control and manipulation of liquids on a micro- and nanoscale. In addition, chip-based approaches are predisposed for synthetic biology applications since they present an opportune technological toolkit capable of fully automated high throughput and content screening under low reagent consumption. This review critically highlights the latest updates in microfluidic cell-free and cell-based protein synthesis as well as the progress on chip-based artificial cells. Even though progress is slow for microfluidic synthetic biology, microfluidic systems are valuable tools for synthetic biology and may one day help to give answers to long asked questions of fundamental cell biology and life itself.

scholarly journals The Tumor-on-Chip: Recent Advances in the Development of Microfluidic Systems to Recapitulate the Physiology of Solid Tumors

Materials ◽  
2019 ◽  
Vol 12 (18) ◽  
pp. 2945 ◽  
Author(s):  
Grissel Trujillo-de Santiago ◽  
Brenda Giselle Flores-Garza ◽  
Jorge Alfonso Tavares-Negrete ◽  
Itzel Montserrat Lara-Mayorga ◽  
Ivonne González-Gamboa ◽  
...  
Keyword(s):  
Cancer Research ◽  
Solid Tumors ◽  
3D Culture ◽  
Microfluidic Devices ◽  
Pharmaceutical Compounds ◽  
Microfluidic Systems ◽  
Cancer Etiology ◽  
Culture Systems ◽  
On Chip

The ideal in vitro recreation of the micro-tumor niche—although much needed for a better understanding of cancer etiology and development of better anticancer therapies—is highly challenging. Tumors are complex three-dimensional (3D) tissues that establish a dynamic cross-talk with the surrounding tissues through complex chemical signaling. An extensive body of experimental evidence has established that 3D culture systems more closely recapitulate the architecture and the physiology of human solid tumors when compared with traditional 2D systems. Moreover, conventional 3D culture systems fail to recreate the dynamics of the tumor niche. Tumor-on-chip systems, which are microfluidic devices that aim to recreate relevant features of the tumor physiology, have recently emerged as powerful tools in cancer research. In tumor-on-chip systems, the use of microfluidics adds another dimension of physiological mimicry by allowing a continuous feed of nutrients (and pharmaceutical compounds). Here, we discuss recently published literature related to the culture of solid tumor-like tissues in microfluidic systems (tumor-on-chip devices). Our aim is to provide the readers with an overview of the state of the art on this particular theme and to illustrate the toolbox available today for engineering tumor-like structures (and their environments) in microfluidic devices. The suitability of tumor-on-chip devices is increasing in many areas of cancer research, including the study of the physiology of solid tumors, the screening of novel anticancer pharmaceutical compounds before resourcing to animal models, and the development of personalized treatments. In the years to come, additive manufacturing (3D bioprinting and 3D printing), computational fluid dynamics, and medium- to high-throughput omics will become powerful enablers of a new wave of more sophisticated and effective tumor-on-chip devices.

Control of pressure-driven components in integrated microfluidic devices using an on-chip electrostatic microvalve

RSC Advances ◽  
2014 ◽  
Vol 4 (93) ◽  
pp. 51593-51602 ◽  
Author(s):  
Joshua D. Tice ◽  
Amit V. Desai ◽  
Thomas A. Bassett ◽  
Christopher A. Apblett ◽  
Paul J. A. Kenis
Keyword(s):  
Microfluidic Devices ◽  
Microfluidic Systems ◽  
On Chip ◽  
Pressure Driven

We report an electrostatic microvalve and microfluidic “pressure-amplifier” circuits used to regulate pressure-driven components (e.g., microvalves) in microfluidic systems.

Recent advancements in chemical luminescence-based lab-on-chip and microfluidic platforms for bioanalysis

2014 ◽  
Vol 87 ◽  
pp. 36-52 ◽  
Author(s):  
Mara Mirasoli ◽  
Massimo Guardigli ◽  
Elisa Michelini ◽  
Aldo Roda
Keyword(s):  
Microfluidic Platforms ◽  
Lab On Chip ◽  
On Chip
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