Control of pressure-driven components in integrated microfluidic devices using an on-chip electrostatic microvalve

RSC Advances ◽  
2014 ◽  
Vol 4 (93) ◽  
pp. 51593-51602 ◽  
Author(s):  
Joshua D. Tice ◽  
Amit V. Desai ◽  
Thomas A. Bassett ◽  
Christopher A. Apblett ◽  
Paul J. A. Kenis
Keyword(s):  
Microfluidic Devices ◽  
Microfluidic Systems ◽  
On Chip ◽  
Pressure Driven

We report an electrostatic microvalve and microfluidic “pressure-amplifier” circuits used to regulate pressure-driven components (e.g., microvalves) in microfluidic systems.

scholarly journals The Tumor-on-Chip: Recent Advances in the Development of Microfluidic Systems to Recapitulate the Physiology of Solid Tumors

Materials ◽  
2019 ◽  
Vol 12 (18) ◽  
pp. 2945 ◽  
Author(s):  
Grissel Trujillo-de Santiago ◽  
Brenda Giselle Flores-Garza ◽  
Jorge Alfonso Tavares-Negrete ◽  
Itzel Montserrat Lara-Mayorga ◽  
Ivonne González-Gamboa ◽  
...  
Keyword(s):  
Cancer Research ◽  
Solid Tumors ◽  
3D Culture ◽  
Microfluidic Devices ◽  
Pharmaceutical Compounds ◽  
Microfluidic Systems ◽  
Cancer Etiology ◽  
Culture Systems ◽  
On Chip

The ideal in vitro recreation of the micro-tumor niche—although much needed for a better understanding of cancer etiology and development of better anticancer therapies—is highly challenging. Tumors are complex three-dimensional (3D) tissues that establish a dynamic cross-talk with the surrounding tissues through complex chemical signaling. An extensive body of experimental evidence has established that 3D culture systems more closely recapitulate the architecture and the physiology of human solid tumors when compared with traditional 2D systems. Moreover, conventional 3D culture systems fail to recreate the dynamics of the tumor niche. Tumor-on-chip systems, which are microfluidic devices that aim to recreate relevant features of the tumor physiology, have recently emerged as powerful tools in cancer research. In tumor-on-chip systems, the use of microfluidics adds another dimension of physiological mimicry by allowing a continuous feed of nutrients (and pharmaceutical compounds). Here, we discuss recently published literature related to the culture of solid tumor-like tissues in microfluidic systems (tumor-on-chip devices). Our aim is to provide the readers with an overview of the state of the art on this particular theme and to illustrate the toolbox available today for engineering tumor-like structures (and their environments) in microfluidic devices. The suitability of tumor-on-chip devices is increasing in many areas of cancer research, including the study of the physiology of solid tumors, the screening of novel anticancer pharmaceutical compounds before resourcing to animal models, and the development of personalized treatments. In the years to come, additive manufacturing (3D bioprinting and 3D printing), computational fluid dynamics, and medium- to high-throughput omics will become powerful enablers of a new wave of more sophisticated and effective tumor-on-chip devices.

scholarly journals Improved method to reduce interfacial defects in bonding polydimethylsiloxane layers of microfluidic devices for lab–on–chip applications

2017 ◽  
Vol 30 (2) ◽  
pp. 25-29
Author(s):  
Salvador Mendoza-Acevedo ◽  
Luis Alfonso Villa-Vargas ◽  
Héctor Francisco Mendoza-León ◽  
Miguel Ángel Alemán-Arce ◽  
Jacobo Esteban Munguía-Cervantes
Keyword(s):  
Oxygen Plasma ◽  
Pressure Sensors ◽  
Microfluidic Devices ◽  
Bonding Process ◽  
Improved Method ◽  
Microfluidic Systems ◽  
Lab On Chip ◽  
Interfacial Defects ◽  
On Chip ◽  
Bonding Method

This work describes a method to achieve a nearly seamless bonding between two polydimethylsiloxane (PDMS) surfaces. This material is widely used to realize microfluidic systems, and obtaining a strong union is an important step in the fabrication process. From the proposed bonding method, a minimal interface is accomplished, useful for hermetic seals in microfluidic systems. The presented method relies in the surface activation by oxygen plasma and the interaction of said treated surface with uncured PDMS. A comparison of bonding methods is presented in this paper in order to assess the performance of the bonding process and verify the interface formed between the bonded surfaces. The intended application of the presented method is the fabrication of pressure sensors, micropumps, microchannels, microfluidic pumps, valves, mixers and other structures that demand a complete seal over the bonded surfaces.

Silicon-Based Lab-on-Chip Device for Acoustic Focusing Applications

2014 ◽  
Author(s):  
Kamran Moradi ◽  
Bilal El-Zahab
Keyword(s):  
Microfluidic Devices ◽  
Acoustic Resonator ◽  
Continuous Method ◽  
Particle Manipulation ◽  
Microfluidic Systems ◽  
Channel Geometry ◽  
Lab On Chip ◽  
Acoustic Focusing ◽  
On Chip ◽  
Silicon Based

Acoustic focusing and separations is a growing field of research since it is an efficient and continuous method for particle manipulation in microfluidic systems. Using microfabrication, microfluidic devices driven by an acoustic resonator were used to focus various microparticle suspensions. By simple tuning of frequency, amplitude, and channel geometry, controllable focusing patterns and alignments were obtained. This approach afforded the separation of particles of contrasting sizes, shapes, densities, porosities, and compressibilities. In this study we present the method for the fabrication of these lab-on-chip devices and report on their performance in the manipulation of microsized particles.

Review of Microfluidic Devices for On-Chip Chemical Sensing

2016 ◽  
Vol 136 (6) ◽  
pp. 244-249
Author(s):  
Takahiro Watanabe ◽  
Fumihiro Sassa ◽  
Yoshitaka Yoshizumi ◽  
Hiroaki Suzuki
Keyword(s):  
Chemical Sensing ◽  
Microfluidic Devices ◽  
On Chip

scholarly journals Measurement and control of pressure driven flows in microfluidic devices using an optofluidic flow sensor

2014 ◽  
Vol 8 (5) ◽  
pp. 054123 ◽  
Author(s):  
Mohammad Sadegh Cheri ◽  
Hamidreza Shahraki ◽  
Jalal Sadeghi ◽  
Mohammadreza Salehi Moghaddam ◽  
Hamid Latifi
Keyword(s):  
Microfluidic Devices ◽  
Flow Sensor ◽  
And Control ◽  
Measurement And Control ◽  
Pressure Driven

scholarly journals Split and flow: reconfigurable capillary connection for digital microfluidic devices

Lab on a Chip ◽  
2014 ◽  
Vol 14 (18) ◽  
pp. 3589-3593 ◽  
Author(s):  
Florian Lapierre ◽  
Maxime Harnois ◽  
Yannick Coffinier ◽  
Rabah Boukherroub ◽  
Vincent Thomy
Keyword(s):  
Microfluidic Devices ◽  
Microfluidic Systems ◽  
Digital Microfluidic

How to take advantage of superhydrophobic microgrids to address the problem of coupling continuous to digital microfluidic systems? A reconfigurable capillary connection for digital microfluidic devices is presented.

Effect of channel geometry on solute dispersion in pressure-driven microfluidic systems

2006 ◽  
Vol 2 (4) ◽  
pp. 275-290 ◽  
Author(s):  
Debashis Dutta ◽  
Arun Ramachandran ◽  
David T. Leighton
Keyword(s):  
Microfluidic Systems ◽  
Channel Geometry ◽  
Solute Dispersion ◽  
Pressure Driven

Versatile acoustic manipulation of micro-object using mode-switchable oscillating bubbles: transportation, trapping, rotation, and revolution

Lab on a Chip ◽  
2021 ◽  
Author(s):  
Wei Zhang ◽  
Bin Song ◽  
Xue Bai ◽  
Lina Jia ◽  
Li Song ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Microfluidic Devices ◽  
Oscillating Bubbles ◽  
Fixed Design ◽  
On Chip

Controllable on-chip multimodal manipulation of micro-objects in microfluidic devices is urgently required for enhancing the efficiency of potential biomedical applications. However, fixed design and driving models make it difficult to...

Design Techniques for Microfluidic Devices Implementation Applicable to Chemical Analysis Systems

2019 ◽  
pp. 195-222 ◽  
Author(s):  
Reinaldo Lucas dos Santos Rosa ◽  
Antonio Carlos Seabra
Keyword(s):  
Chemical Analysis ◽  
Solid Phase ◽  
Microfluidic Devices ◽  
Water Quality Monitoring ◽  
Analysis Process ◽  
Micro Total Analysis Systems ◽  
Total Analysis ◽  
On Chip ◽  
Separation Cell ◽  
High Level

This chapter provides a guide for microfluidic devices development and optimization focused on chemical analysis applications, which includes medicine, biology, chemistry, and environmental monitoring, showing high-level performance associated with a specific functionality. Examples are chemical analysis, solid phase extraction, chromatography, immunoassay analysis, protein and DNA separation, cell sorting and manipulation, cellular biology, and mass spectrometry. In this chapter, most information is related to microfluidic devices design and fabrication used to perform several steps concerning chemical analysis, process preparation of reagents, samples reaction and detection, regarding water quality monitoring. These steps are especially relevant to lab-on-chip (LOC) and micro-total-analysis-systems (μTAS). μTAS devices are developed in order to simplify analytical chemist work, incorporating several analytical procedures into flow systems. In the case of miniaturized devices, the analysis time is reduced, and small volumes (nL) can be used.

scholarly journals Rheology and microstructural evolution in pressure-driven flow of a magnetorheological fluid with strong particle–wall interactions

2012 ◽  
Vol 23 (9) ◽  
pp. 969-978 ◽  
Author(s):  
Murat Ocalan ◽  
Gareth H. McKinley
Keyword(s):  
Microfluidic Devices ◽  
Magnetorheological Fluid ◽  
Time Dependent ◽  
Mr Fluid ◽  
Flow Through ◽  
Fluid Particles ◽  
And Performance ◽  
Pressure Driven Flow ◽  
Actuator Design ◽  
Pressure Driven

The interaction between magnetorheological (MR) fluid particles and the walls of the device that retain the field-responsive fluid is critical as this interaction provides the means for coupling the physical device to the field-controllable properties of the fluid. This interaction is often enhanced in actuators by the use of ferromagnetic walls that generate an attractive force on the particles in the field-on state. In this article, the aggregation dynamics of MR fluid particles and the evolution of the microstructure in pressure-driven flow through ferromagnetic channels are studied using custom-fabricated microfluidic devices with ferromagnetic sidewalls. The aggregation of the particles and the time-dependent evolution in the microstructure is studied in rectilinear, expansion and contraction channel geometries. These observations help identify methods for improving MR actuator design and performance.

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