Lignin valorization for protocatechuic acid production in engineered Saccharomyces cerevisiae

2021 ◽  
Author(s):  
Ren-Kuan Zhang ◽  
Yong-Shui Tan ◽  
You-Zhi Cui ◽  
Xin Xin ◽  
Zhi-Hua Liu ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Acid Production ◽  
Protocatechuic Acid ◽  
Lignin Valorization ◽  
Engineered Saccharomyces Cerevisiae

A biological funnel pathway was established for the production of protocatechuic acid from lignin in engineered Saccharomyces cerevisiae.

Lactic acid production from xylose by engineered Saccharomyces cerevisiae without PDC or ADH deletion

2015 ◽  
Vol 99 (19) ◽  
pp. 8023-8033 ◽  
Author(s):  
Timothy L. Turner ◽  
Guo-Chang Zhang ◽  
Soo Rin Kim ◽  
Vijay Subramaniam ◽  
David Steffen ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Lactic Acid ◽  
Acid Production ◽  
Lactic Acid Production ◽  
Engineered Saccharomyces Cerevisiae

d-Lactic acid production by metabolically engineered Saccharomyces cerevisiae

2006 ◽  
Vol 101 (2) ◽  
pp. 172-177 ◽  
Author(s):  
Nobuhiro Ishida ◽  
Tomiko Suzuki ◽  
Kenro Tokuhiro ◽  
Eiji Nagamori ◽  
Toru Onishi ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Lactic Acid ◽  
Acid Production ◽  
Lactic Acid Production ◽  
Engineered Saccharomyces Cerevisiae

L‐malic acid production from xylose by engineered Saccharomyces cerevisiae

2021 ◽  
pp. 2000431
Author(s):  
Nam Kyu Kang ◽  
Jae Won Lee ◽  
Donald R. Ort ◽  
Yong‐Su Jin
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Malic Acid ◽  
Acid Production ◽  
Engineered Saccharomyces Cerevisiae

Enhancing oleanolic acid production in engineered Saccharomyces cerevisiae

2018 ◽  
Vol 257 ◽  
pp. 339-343 ◽  
Author(s):  
Yujia Zhao ◽  
Jingjing Fan ◽  
Chen Wang ◽  
Xudong Feng ◽  
Chun Li
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Oleanolic Acid ◽  
Acid Production ◽  
Engineered Saccharomyces Cerevisiae

scholarly journals l-Lactic Acid Production Using Engineered Saccharomyces cerevisiae with Improved Organic Acid Tolerance

2021 ◽  
Vol 7 (11) ◽  
pp. 928
Author(s):  
Byeong-Kwan Jang ◽  
Yebin Ju ◽  
Deokyeol Jeong ◽  
Sung-Keun Jung ◽  
Chang-Kil Kim ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Acetic Acid ◽  
Lactic Acid ◽  
Acid Production ◽  
Lactic Acid Production ◽  
Acid Tolerance ◽  
Production Costs ◽  
High Concentration ◽  
Adaptive Laboratory Evolution ◽  
Engineered Saccharomyces Cerevisiae

Lactic acid is mainly used to produce bio-based, bio-degradable polylactic acid. For industrial production of lactic acid, engineered Saccharomyces cerevisiae can be used. To avoid cellular toxicity caused by lactic acid accumulation, pH-neutralizing agents are used, leading to increased production costs. In this study, lactic acid-producing S. cerevisiae BK01 was developed with improved lactic acid tolerance through adaptive laboratory evolution (ALE) on 8% lactic acid. The genetic basis of BK01 could not be determined, suggesting complex mechanisms associated with lactic acid tolerance. However, BK01 had distinctive metabolomic traits clearly separated from the parental strain, and lactic acid production was improved by 17% (from 102 g/L to 119 g/L). To the best of our knowledge, this is the highest lactic acid titer produced by engineered S. cerevisiae without the use of pH neutralizers. Moreover, cellulosic lactic acid production by BK01 was demonstrated using acetate-rich buckwheat husk hydrolysates. Particularly, BK01 revealed improved tolerance against acetic acid of the hydrolysates, a major fermentation inhibitor of lignocellulosic biomass. In short, ALE with a high concentration of lactic acid improved lactic acid production as well as acetic acid tolerance of BK01, suggesting a potential for economically viable cellulosic lactic acid production.

Effect of magnesium ions on glucaric acid production in the engineered Saccharomyces cerevisiae

2021 ◽  
Vol 332 ◽  
pp. 61-71
Author(s):  
Yunying Zhao ◽  
Jie Li ◽  
Ruifang Su ◽  
Yingli Liu ◽  
Jing Wang ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Acid Production ◽  
Magnesium Ions ◽  
Glucaric Acid ◽  
Engineered Saccharomyces Cerevisiae
Sign in / Sign up

Export Citation Format

Share Document