Pd/Cu-free Magnetic Cobalt Catalyst for C-N cross Coupling Reactions: Synthesis of Abemaciclib and Fedratinib

2021 ◽  
Author(s):  
Zahra Khorsandi ◽  
Abdol R. Hajipour ◽  
Mohammad R. Sarfjoua ◽  
Rajender S Varma
Keyword(s):  
Magnetic Nanoparticles ◽  
Functional Groups ◽  
Cobalt Catalyst ◽  
Cross Coupling ◽  
Catalyst System ◽  
Coupling Reactions ◽  
Cross Coupling Reactions ◽  
Nano Catalyst ◽  
Natural Ligands ◽  
Cobalt Species

Herein, the synthesis of a nano-catalyst system comprising magnetic nanoparticles as core and edible natural ligands bearings functional groups for supporting the cobalt species was accomplished. Subsequent to characterization, its...

A Highly Active Cobalt Catalyst System for Kumada Biaryl Cross-Coupling

Synlett ◽  
2018 ◽  
Vol 29 (09) ◽  
pp. 1199-1202 ◽  
Author(s):  
Wenqin Wu ◽  
Hung Duong
Keyword(s):  
Room Temperature ◽  
Cobalt Catalyst ◽  
Cross Coupling ◽  
Catalyst System ◽  
Coupling Reactions ◽  
Short Reaction Time ◽  
Cross Coupling Reactions ◽  
Highly Active ◽  
Aryl Bromides ◽  
Wide Range

A highly active cobalt catalyst system has been developed for the cross-coupling reactions of arylmagnesium reagents and aryl bromides. In the presence of 1 mol% CoCl2, 2 mol% IPr·HCl and 2 mol% NaO t Bu, a wide range of (hetero)biaryls are prepared in 51–99% yields at room temperature within a short reaction time.

Carbon-Heteroatom Cross-Coupling via an Electronically Excited Nickel (II) Complex

2019 ◽  
Author(s):  
Randolph Escobar ◽  
Jeffrey Johannes
Keyword(s):  
Energy Transfer ◽  
Functional Groups ◽  
Cross Coupling ◽  
Reductive Elimination ◽  
Aryl Halides ◽  
Coupling Reactions ◽  
General Methodology ◽  
Cross Coupling Reactions ◽  
Electronically Excited ◽  
Energy Transfer Pathway

<div>While carbon-heteroatom cross coupling reactions have been extensively studied, many methods are specific and</div><div>limited to a set of substrates or functional groups. Reported here is a method that allows for C-O, C-N and C-S cross coupling reactions under one general methodology. We propose that an energy transfer pathway, in which an iridium photosensitizer produces an excited nickel (II) complex, is responsible for the key reductive elimination step that couples aryl halides to 1° and 2° alcohols, anilines, thiophenols, carbamates and sulfonamides.</div>

PEPPSI-SONO-SP2: a new highly efficient ligand-free catalyst system for the synthesis of tri-substituted triazine derivatives via Suzuki–Miyaura and Sonogashira coupling reactions under a green approach

2016 ◽  
Vol 40 (6) ◽  
pp. 5135-5142 ◽  
Author(s):  
Motakatla Venkata Krishna Reddy ◽  
Peddiahgari Vasu Govardhana Reddy ◽  
Cirandur Suresh Reddy
Keyword(s):  
Palladium Catalyst ◽  
Cross Coupling ◽  
Catalyst System ◽  
Coupling Reactions ◽  
Sonogashira Coupling ◽  
Reaction Conditions ◽  
Cross Coupling Reactions ◽  
Green Approach ◽  
Ligand Free ◽  
Triazine Derivatives

Consecutive Suzuki–Miyaura and Sonogashira cross coupling reactions catalyzed by a new competent palladium catalyst PEPPSI-SONO-SP2 under mild and green reaction conditions.

scholarly journals A phase-reversible Pd containing sphere-to-bridge-shaped peptide nanostructure for cross-coupling reactions

RSC Advances ◽  
2017 ◽  
Vol 7 (53) ◽  
pp. 33162-33165 ◽  
Author(s):  
Seongsoo Kim ◽  
Hong-Jun Cho ◽  
Namhun Lee ◽  
Yoon-Sik Lee ◽  
Dong-Sik Shin ◽  
...  
Keyword(s):  
Cross Coupling ◽  
Coupling Reactions ◽  
Cross Coupling Reactions ◽  
Nano Catalyst

A sphere-to-bridge-shaped peptide/Pd(ii) nanostructure was constructed and used as a recyclable Pd nano-catalyst for cross-coupling reactions.

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