scholarly journals Correction: The gut microbiota mediates the protective effects of anserine supplementation on hyperuricaemia and associated renal inflammation

2022 ◽  
Author(s):  
Jiaojiao Han ◽  
Ziyan Wang ◽  
Chenyang Lu ◽  
Jun Zhou ◽  
Ye Li ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Protective Effects ◽  
Renal Inflammation

Correction for ‘The gut microbiota mediates the protective effects of anserine supplementation on hyperuricaemia and associated renal inflammation’ by Jiaojiao Han et al., Food Funct., 2021, 12, 9030–9042, DOI: 10.1039/D1FO01884A.

The gut microbiota mediates the protective effects of anserine supplementation on hyperuricaemia and associated renal inflammation

2021 ◽  
Author(s):  
Jiaojiao Han ◽  
Ziyan Wang ◽  
Chenyang Lu ◽  
Jun Zhou ◽  
Ye Li ◽  
...  
Keyword(s):  
Uric Acid ◽  
Side Effects ◽  
Gut Microbiota ◽  
Serum Uric Acid ◽  
Acid Content ◽  
Elevated Serum ◽  
Protective Effects ◽  
Renal Inflammation

Hyperuricaemia is a disease associated with elevated serum uric acid content, which has emerged rapidly in recent decades. The drugs used to treat clinical hyperuricaemia have side effects, and their...

Protective effects of tuna meat oligopeptides (TMOP) supplementation on hyperuricemia and associated renal inflammation mediated by gut microbiota

2020 ◽  
Vol 34 (4) ◽  
pp. 5061-5076 ◽  
Author(s):  
Jiaojiao Han ◽  
Xiaofeng Wang ◽  
Shasha Tang ◽  
Chenyang Lu ◽  
Haitao Wan ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Protective Effects ◽  
Renal Inflammation

scholarly journals Dietary Interventions to Prevent High Fructose Diet-associated Worsening of Colitis and Colitis-associated Tumorigenesis in Mice

2021 ◽  
Author(s):  
Ryohei Nishiguchi ◽  
Srijani Basu ◽  
Hannah A Staab ◽  
Naotake Ito ◽  
Xi Kathy Zhou ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Control Diet ◽  
Experimental Colitis ◽  
Protective Effects ◽  
Diet Change ◽  
Chronic Colitis ◽  
Acute Colitis ◽  
High Fructose Diet ◽  
High Consumption ◽  
High Fructose

Abstract Diet is believed to be an important factor in the pathogenesis of Inflammatory Bowel Disease. High consumption of dietary fructose has been shown to exacerbate experimental colitis, an effect mediated through the gut microbiota. This study evaluated whether dietary alterations could attenuate the detrimental effects of a high fructose diet (HFrD) in experimental colitis. First, we determined whether the pro-colitic effects of a HFrD could be reversed by switching mice from a HFrD to a control diet. This diet change completely prevented HFrD-induced worsening of acute colitis, in association with a rapid normalization of the microbiota. Second, we tested the effects of dietary fiber, which demonstrated that psyllium was the most effective type of fiber for protecting against HFrD-induced worsening of acute colitis, compared to pectin, inulin or cellulose. In fact, supplemental psyllium nearly completely prevented the detrimental effects of the HFrD, an effect associated with a shift in the gut microbiota. We next determined whether the protective effects of these interventions could be extended to chronic colitis and colitis-associated tumorigenesis. Using the azoxymethane/dextran sodium sulfate model, we first demonstrated that HFrD feeding exacerbated chronic colitis and increased colitis-associated tumorigenesis. Using the same dietary changes tested in the acute colitis setting, we also showed that mice were protected from HFrD-mediated enhanced chronic colitis and tumorigenesis, upon either diet switching or psyllium supplementation. Taken together, these findings suggest that high consumption of fructose may enhance colon tumorigenesis associated with long-standing colitis, an effect that could be reduced by dietary alterations.

scholarly journals Dietary resveratrol attenuation of intestinal inflammation and oxidative damage is linked to the alteration of gut microbiota and butyrate in piglets challenged with deoxynivalenol

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yueqin Qiu ◽  
Jun Yang ◽  
Li Wang ◽  
Xuefen Yang ◽  
Kaiguo Gao ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Oxidative Damage ◽  
Protein Expression ◽  
Intestinal Inflammation ◽  
Control Diet ◽  
Intestinal Barrier Function ◽  
Protective Effects ◽  
Gut Health ◽  
Antioxidant Genes ◽  
Mrna And Protein Expression

Abstract Background Deoxynivalenol (DON) is a widespread mycotoxin that induces intestinal inflammation and oxidative stress in humans and animals. Resveratrol (RES) effectively exerts anti-inflammatory and antioxidant effects. However, the protective effects of RES on alleviating DON toxicity in piglets and the underlying mechanism remain unclear. Therefore, this study aimed to investigate the effect of RES on growth performance, gut health and the gut microbiota in DON-challenged piglets. A total of 64 weaned piglets [Duroc × (Landrace × Yorkshire), 21-d-old, 6.97 ± 0.10 kg body weight (BW)] were randomly allocated to 4 treatment groups (8 replicate pens per treatment, each pen containing 2 males; n = 16 per treatment) for 28 d. The piglets were fed a control diet (CON) or the CON diet supplemented with 300 mg RES/kg diet (RES group), 3.8 mg DON/kg diet (DON) or both (DON+RES) in a 2 × 2 factorial design. Results DON-challenged piglets fed the RES-supplemented diet had significantly decreased D-lactate concentrations and tumor necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β) mRNA and protein expression, and increased zonula occludens-1 (ZO-1) mRNA and protein expression compared with those of DON-challenged piglets fed the unsupplemented diet (P < 0.05). Compared with unsupplemented DON-challenged piglets, infected piglets fed a diet with RES showed significantly decreased malondialdehyde (MDA) levelsand increased mRNA expression of antioxidant enzymes and antioxidant genes (i.e., GCLC, GCLM, HO-1, SOD1 and NQO-1) and glutamate-cysteine-ligase modulatory subunit (GCLM) protein expression (P < 0.05). Moreover, RES supplementation significantly abrogated the increase in the proportion of TUNEL-positive cells and the protein expression of caspase3 in DON-challenged piglets (P < 0.05). Finally, RES supplementation significantly increased the abundance of Roseburia and butyrate concentrations, while decreasing the abundances of Bacteroides and unidentified-Enterobacteriaceae in DON-challenged piglets compared with DON-challenged piglets alone (P < 0.05). Conclusions RES supplementation improved gut health in DON-challenged piglets by strengthening intestinal barrier function, alleviating intestinal inflammation and oxidative damage, and positively modulating the gut microbiota. The protective effects of RES on gut health may be linked to increased Roseburia and butyrate concentrations, and decreased levels of Bacteroides and unidentified-Enterobacteriaceae.

The protective effects of yellow tea extract against loperamide-induced constipation in mice

2021 ◽  
Author(s):  
Pei-Qin Cao ◽  
Xiu-Ping Li ◽  
Jian Ou-Yang ◽  
Rong-Gang Jiang ◽  
Fang-Fang Huang ◽  
...  
Keyword(s):  
16S Rrna ◽  
Gut Microbiota ◽  
16S Rrna Gene ◽  
Gene Sequencing ◽  
16S Rrna Gene Sequencing ◽  
Rrna Gene ◽  
Protective Effects ◽  
Rrna Gene Sequencing ◽  
Tea Extract

We evaluated the effects of yellow tea extract on relieving constipation induced by loperamide and evaluated the changes of gut microbiota based on 16S rRNA gene sequencing.

scholarly journals Citrus polymethoxyflavones attenuate metabolic syndrome by regulating gut microbiome and amino acid metabolism

2020 ◽  
Vol 6 (1) ◽  
pp. eaax6208 ◽  
Author(s):  
Su-Ling Zeng ◽  
Shang-Zhen Li ◽  
Ping-Ting Xiao ◽  
Yuan-Yuan Cai ◽  
Chu Chu ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Amino Acid ◽  
Gut Microbiota ◽  
Metabolic Diseases ◽  
Amplicon Sequencing ◽  
Therapeutic Interventions ◽  
Protective Effects ◽  
Fecal Microbiome ◽  
Metabolomic Profiling ◽  
Branched Chain

Metabolic syndrome (MetS) is intricately linked to dysregulation of gut microbiota and host metabolomes. Here, we first find that a purified citrus polymethoxyflavone-rich extract (PMFE) potently ameliorates high-fat diet (HFD)–induced MetS, alleviates gut dysbiosis, and regulates branched-chain amino acid (BCAA) metabolism using 16S rDNA amplicon sequencing and metabolomic profiling. The metabolic protective effects of PMFE are gut microbiota dependent, as demonstrated by antibiotic treatment and fecal microbiome transplantation (FMT). The modulation of gut microbiota altered BCAA levels in the host serum and feces, which were significantly associated with metabolic features and actively responsive to therapeutic interventions with PMFE. Notably, PMFE greatly enriched the commensal bacterium Bacteroides ovatus, and gavage with B. ovatus reduced BCAA concentrations and alleviated MetS in HFD mice. PMFE may be used as a prebiotic agent to attenuate MetS, and target-specific microbial species may have unique therapeutic promise for metabolic diseases.

Gut microbiota mediated the protective effects of tuna oil on collagen-induced arthritis in mice

2021 ◽  
Author(s):  
Chenyang Lu ◽  
Ju Chen ◽  
Congmin Yi ◽  
Jiaojiao Han ◽  
Qiuyue Shi ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Autoimmune Disease ◽  
Gut Microbiota ◽  
Protective Effects ◽  
Collagen Induced Arthritis ◽  
Tuna Oil ◽  
Beneficial Effects ◽  
Chronic Autoimmune Disease

Rheumatoid arthritis is emerging as a chronic autoimmune disease worldwide. In this study, the components of tuna oil (TO) were firstly measured, and the beneficial effects of TO on collagen-induced...

Synergistic Protective Effects of Different Dietary Supplements Against Type 2 Diabetes via Regulating Gut Microbiota

2021 ◽  
Vol 24 (3) ◽  
pp. 319-330
Author(s):  
Leilei Yu ◽  
Xingting Zhou ◽  
Hui Duan ◽  
Ying Chen ◽  
Shumao Cui ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Gut Microbiota ◽  
Dietary Supplements ◽  
Protective Effects

scholarly journals Interaction with Gut Microbiota Plays a Causative Role in Grape Powder-Mediated Anti-Colitis Effects in Mice

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 499-499
Author(s):  
Yiying Zhao ◽  
Qing Jiang
Keyword(s):  
Gut Microbiota ◽  
Rectal Bleeding ◽  
Tissue Damage ◽  
Control Diet ◽  
Spleen Weight ◽  
Causative Role ◽  
Protective Effects ◽  
Gut Health ◽  
Colonic Tissue ◽  
Microbial Composition

Abstract Objectives Gut microbiota is recognized to play a regulatory role in gut health and diseases. Previously, in a mouse model of colitis-associated colorectal cancer, we found that 10% grape powder (10GP) diet, which contains 0.033% polyphenols, attenuated colitis symptoms and restored colitis-changed gut microbial composition. However, it is not clear whether microbial modulation by 10GP directly contributes to the observed protective effects. To address the question, we compared the effect of 10GP on colitis in the presence and absence of antibiotics in mice. Methods Male Balb/c mice were gavaged with either water or antibiotic cocktail (ABX) daily for 7 days. For both water and ABX-treated mice, we further divided them into three subgroups: 1) healthy control (non-DSS), 2) mice fed with control diet and treated by 1.8% dextran sodium sulfate (DSS) in drinking water, and 3) mice fed with 10GP diet and treated with DSS (DSS-10GP). During the study, we monitored mice’ body weight and evaluated their colitis symptoms including stool consistency and rectal bleeding. All mice were sacrificed 9–10 days after DSS administration. Results Compared with conventional mice, ABX-treated mice had lowered liver and colon weight, increased level of fecal acetate and decreased levels of fecal butyrate and propionate. For both conventional and ABX-treated mice, DSS treatment caused colitis symptoms including rectal bleeding and diarrhea, colonic tissue damage, increased spleen weight and shortened colon length. Importantly, 10GP significantly alleviated DSS-induced colitis symptoms in non-ABX conventional mice, as indicated by attenuated fecal bleeding and diarrhea, reduced colonic tissue damage, and lowered spleen weight and colon weight to length ratio as inflammatory indexes. In contrast, these protective effects of 10GP were not observed in the ABX-treated mice. Conclusions 10GP diet showed protective effects against DSS-induced colitis in conventional mice, but not ABX-treated mice. This observation indicates that interaction between 10GP and gut microbiota plays a causative role in 10GP-mediated protective effects on colitis. Funding Sources California Table Grape Commission.

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