Effects of Concord grape juice flavor intensity and phenolic compound content on glycemia, appetite and cognitive function in adults with excess body weight: a randomized double-blind crossover trial

2021 ◽  
Author(s):  
Olivia Coelho ◽  
Rita de Cássia Gonçalves Alfenas ◽  
hawi Debelo ◽  
JoLynne Wightman ◽  
Mario G. Ferruzzi ◽  
...  
Keyword(s):  
Crossover Trial ◽  
Grape Juice ◽  
Polyphenolic Compounds ◽  
Sensory Profile ◽  
Excess Body Weight ◽  
Unique Combination ◽  
Health It ◽  
Double Blind ◽  
Flavor Intensity ◽  
Concord Grape

Background & Aims: Concord grape (Vitis lambrusca) juice (CGJ) contains a unique combination of polyphenolic compounds with diverse effects on human health. It also has an intense sensory profile that...

Colonic catabolism of dietary phenolic and polyphenolic compounds from Concord grape juice

2013 ◽  
Vol 4 (1) ◽  
pp. 52-62 ◽  
Author(s):  
Angelique Stalmach ◽  
Christine A. Edwards ◽  
JoLynne D. Wightman ◽  
Alan Crozier
Keyword(s):  
Grape Juice ◽  
Polyphenolic Compounds ◽  
Concord Grape

scholarly journals Safety, Tolerability and Efficacy of Dietary Supplementation with Concord Grape Juice in Gulf War Veterans with Gulf War Illness: A Phase I/IIA, Randomized, Double-Blind, Placebo-Controlled Trial

2020 ◽  
Vol 17 (10) ◽  
pp. 3546
Author(s):  
Drew A. Helmer ◽  
William W. Van Doren ◽  
David R. Litke ◽  
Chin-Lin Tseng ◽  
Lap Ho ◽  
...  
Keyword(s):  
Phase I ◽  
Controlled Trial ◽  
Grape Juice ◽  
Gulf War ◽  
Linear Regression Models ◽  
Gulf War Illness ◽  
Double Blind ◽  
Gulf War Veterans ◽  
Efficacy Measures ◽  
Concord Grape

Approximately 30 percent of U.S. veterans deployed during the Gulf War (1990–1991) have been diagnosed with Gulf War Illness (GWI), a chronic multi-symptom disorder without widely available specific treatments. We investigated whether the consumption of Concord grape juice (CGJ), rich in anti-inflammatory flavonoids, would be tolerated and safe in individuals with GWI and explored improvement in cognitive function and fatigue. Thirty-six veterans with GWI enrolled in a 24-week randomized, double-blind, Phase I/IIA clinical trial to explore safety, tolerability, and feasibility of 16 ounces daily of commercially available CGJ compared to placebo. Participants completed neurocognitive tests and self-reported surveys at baseline, 12 and 24 weeks. Thirty-one participants (86%) completed the study; no dropouts were related to side effects. Thirty participants (83%) documented ≥80% adherence. There were no statistically significant unadjusted differences between CGJ and placebo groups in change in efficacy measures from baseline to endpoint. We employed general linear regression models controlling for baseline differences between groups which indicated statistically significant improvement in the Halstead Category Test–Russell Revised Version (RCAT) at endpoint in the CGJ group compared to placebo (8.4 points, p = 0.04). Other measures of cognitive functioning did not indicate significant improvements in the adjusted analyses (p-values: 0.09–0.32), nor did the fatigue variable (p = 0.67). CGJ was safe and well-tolerated by veterans with GWI. Our data suggest high tolerability and potential benefit from CGJ in veterans with GWI and can be used to inform future studies of efficacy.

scholarly journals Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment

2009 ◽  
Vol 103 (5) ◽  
pp. 730-734 ◽  
Author(s):  
Robert Krikorian ◽  
Tiffany A. Nash ◽  
Marcelle D. Shidler ◽  
Barbara Shukitt-Hale ◽  
James A. Joseph
Keyword(s):  
Older Adults ◽  
Memory Function ◽  
Verbal Learning ◽  
Grape Juice ◽  
Vascular Pathology ◽  
Appreciable Effect ◽  
Double Blind ◽  
Memory Decline ◽  
Neuronal Signalling ◽  
Concord Grape

Concord grape juice contains polyphenol compounds, which have antioxidant and anti-inflammatory properties and influence neuronal signalling. Concord grape juice supplementation has been shown to reduce inflammation, blood pressure and vascular pathology in individuals with CVD, and consumption of such flavonoid-containing foods is associated with a reduced risk for dementia. In addition, preliminary animal data have indicated improvement in memory and motor function with grape juice supplementation, suggesting potential for cognitive benefit in ageing humans. In this initial investigation of neurocognitive effects, we enrolled twelve older adults with memory decline but not dementia in a randomised, placebo-controlled, double-blind trial with Concord grape juice supplementation for 12 weeks. We observed significant improvement in a measure of verbal learning and non-significant enhancement of verbal and spatial recall. There was no appreciable effect of the intervention on depressive symptoms and no effect on weight or waist circumference. A small increase in fasting insulin was observed for those consuming grape juice. These preliminary findings suggest that supplementation with Concord grape juice may enhance cognitive function for older adults with early memory decline and establish a basis for more comprehensive investigations to evaluate potential benefit and assess mechanisms of action.

Sign in / Sign up

Export Citation Format

Share Document