scholarly journals Beneficial effects of cinnamon and its extracts in the management of cardiovascular diseases and diabetes

2021 ◽  
Author(s):  
Chang Shang ◽  
Hongchen Lin ◽  
Xuqin Fang ◽  
Yuling Wang ◽  
Zhilin Jiang ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Causes Of Death ◽  
Beneficial Effects ◽  
Urgent Necessity

Cardiovascular diseases (CVDs) and diabetes are the leading causes of death worldwide, which underlines the urgent necessity to develop new pharmacotherapies. Cinnamon has been an eminent component of spice and...

scholarly journals The Effect of Resveratrol on the Cardiovascular System from Molecular Mechanisms to Clinical Results

2021 ◽  
Vol 22 (18) ◽  
pp. 10152
Author(s):  
Roland Gal ◽  
Laszlo Deres ◽  
Kalman Toth ◽  
Robert Halmosi ◽  
Tamas Habon
Keyword(s):  
Cardiovascular Diseases ◽  
Cardiovascular System ◽  
Molecular Mechanisms ◽  
Causes Of Death ◽  
Antioxidant Properties ◽  
Clinical Results ◽  
Beneficial Effects ◽  
Pathological Conditions ◽  
Cardioprotective Effects ◽  
Anti Inflammatory

Cardiovascular diseases are the leading causes of death worldwide. The cardioprotective effects of natural polyphenols such as resveratrol (3,5,4-trihydroxystilbene) have been extensively investigated throughout recent decades. Many studies of RES have focused on its favorable effects on pathological conditions related to cardiovascular diseases and their risk factors. The aim of this review was to summarize the wide beneficial effects of resveratrol on the cardiovascular system, including signal transduction pathways of cell longevity, energy metabolism of cardiomyocytes or cardiac remodeling, and its anti-inflammatory and antioxidant properties. In addition, this paper discusses the significant preclinical and human clinical trials of recent years with resveratrol on cardiovascular system. Finally, we present a short overview of antiviral and anti-inflammatory properties and possible future perspectives on RES against COVID-19 in cardiovascular diseases.

Wearable Triboelectric Nanogenerators for Heart Rate Monitoring

2021 ◽  
Author(s):  
Sophia Shen ◽  
Xiao Xiao ◽  
Xiao Xiao ◽  
Jun Chen
Keyword(s):  
Heart Rate ◽  
Cardiovascular Diseases ◽  
Causes Of Death ◽  
Heart Rate Monitoring ◽  
Triboelectric Nanogenerators ◽  
Physiological Indicator

Cardiovascular diseases are currently the leading causes of death globally and are projected to remain the leading cause in 2040, making heart rate an important physiological indicator to regularly monitor....

Resveratrol and cardiac fibrosis prevention and treatment

2021 ◽  
Vol 22 ◽  
Author(s):  
Parinaz Zivarpour ◽  
Željko Reiner ◽  
Jamal Hallajzadeh ◽  
Liaosadat Mirsafaei
Keyword(s):  
Cardiovascular Diseases ◽  
Cardiac Fibrosis ◽  
Therapeutic Potential ◽  
Developed Countries ◽  
Clinical Results ◽  
Matrix Proteins ◽  
Protective Effects ◽  
Beneficial Effects ◽  
Laboratory Models

: Cardiovascular diseases are some of the major causes of morbidity and mortality in developed or developing countries but in developed countries as well. Cardiac fibrosis is one of the most often pathological changes of heart tissues. It occurs as a result of extracellular matrix proteins accumulation at myocardia. Cardiac fibrosis results in impaired cardiac systolic and diastolic functions and is associated with other effects. Therapies with medicines have not been sufficiently successful in treating chronic diseases such as CVD. Therefore, the interest for therapeutic potential of natural compounds and medicinal plants has increased. Plants such as grapes, berries and peanuts contain a polyphenolic compound called "resveratrol" which has been reported to have various therapeutic properties for a variety of diseases. Studies on laboratory models that show that resveratrol has beneficial effects on cardiovascular diseases including myocardial infarction, high blood pressure cardiomyopathy, thrombosis, cardiac fibrosis, and atherosclerosis. In vitro animal models using resveratrol indicated protective effects on the heart by neutralizing reactive oxygen species, preventing inflammation, increasing neoangiogenesis, dilating blood vessels, suppressing apoptosis and delaying atherosclerosis. In this review, we are presenting experimental and clinical results of studies concerning resveratrol effects on cardiac fibrosis as a CVD outcome in humans.

scholarly journals Cell-Based Therapies for Cardiac Regeneration: A Comprehensive Review of Past and Ongoing Strategies

2018 ◽  
Vol 19 (10) ◽  
pp. 3194 ◽  
Author(s):  
Andrea Ghiroldi ◽  
Marco Piccoli ◽  
Federica Cirillo ◽  
Michelle Monasky ◽  
Giuseppe Ciconte ◽  
...  
Keyword(s):  
Causes Of Death ◽  
Ventricular Dysfunction ◽  
State Of The Art ◽  
Cardiac Regeneration ◽  
Cell Types ◽  
Left Ventricular ◽  
Principal Mechanism ◽  
Beneficial Effects ◽  
Clinical Conditions ◽  
Different Cell Types

Despite considerable improvements in the treatment of cardiovascular diseases, heart failure (HF) still represents one of the leading causes of death worldwide. Poor prognosis is mostly due to the limited regenerative capacity of the adult human heart, which ultimately leads to left ventricular dysfunction. As a consequence, heart transplantation is virtually the only alternative for many patients. Therefore, novel regenerative approaches are extremely needed, and several attempts have been performed to improve HF patients’ clinical conditions by promoting the replacement of the lost cardiomyocytes and by activating cardiac repair. In particular, cell-based therapies have been shown to possess a great potential for cardiac regeneration. Different cell types have been extensively tested in clinical trials, demonstrating consistent safety results. However, heterogeneous efficacy data have been reported, probably because precise end-points still need to be clearly defined. Moreover, the principal mechanism responsible for these beneficial effects seems to be the paracrine release of antiapoptotic and immunomodulatory molecules from the injected cells. This review covers past and state-of-the-art strategies in cell-based heart regeneration, highlighting the advantages, challenges, and limitations of each approach.

scholarly journals HRIDROGA – AN OUTLOOK THROUGH SAMANYA LAKSHANA

2021 ◽  
Vol 9 (9) ◽  
pp. 2084-2087
Author(s):  
Ashwini P K ◽  
Geetha B Markande ◽  
Prashanth Jain
Keyword(s):  
Chest Pain ◽  
Cardiovascular Diseases ◽  
Causes Of Death ◽  
Signs And Symptoms ◽  
Presenting Symptoms ◽  
Unique Approach ◽  
Cardiac Disorders ◽  
Proper Analysis

Hridroga (cardiovascular diseases) are the major causes of death globally, taking an estimated 17.9 million lives each year. In view of increasing incidence of cardiac disorders in the present era, there is a need to understand the disease more elaborately. Ayurveda has a unique approach towards understanding and diagnosing diseases. Diag- nosis must be done by proper analysis of presenting symptoms of a disease. By the thorough knowledge regarding these signs and symptoms, right diagnosis can be done before planning any treatment. Ayurveda has given utmost importance for diagnosis with due consideration of Lakshanas. Hritshoola (chest pain), Vaivarnya (cyanosis), Moorcha (syncope), Shwasa (dyspnea), Kasa (cough) are the cardinal features of Hridroga. By knowing the whole concept of Lakshanas, diagnosis can be done at an earlier stage. Keywords: Hridroga, Cardiovascular diseases, Samanya Lakshanas

scholarly journals Causes of death in Serbia since the mid-20th century

Stanovnistvo ◽  
2012 ◽  
Vol 50 (1) ◽  
pp. 89-106
Author(s):  
Ivan Marinkovic
Keyword(s):  
Cardiovascular Diseases ◽  
Infectious Diseases ◽  
20Th Century ◽  
Cause Of Death ◽  
21St Century ◽  
Causes Of Death ◽  
Total Population ◽  
Total Mortality ◽  
Population Mortality ◽  
Circulatory Diseases

The structure of the leading causes of death in Serbia has considerably changed in the last half century. Diseases which presented the main threat to the population a few decades ago are now at the level of a statistical error. On the one side are causes which drastically changed their share in total mortality in this time interval, while others have shown stability and persistence among the basic causes of death. Acute infectious diseases "have been replaced" with chronic noninfectious diseases, due to the improvement of general and health conditions. One of the consequences of such changes is increased life expectancy and a larger share of older population which resulted in cardiovascular diseases and tumors to dominate more and more in total mortality. Convergent trends in the structure of the leading causes of death in Serbia from the middle of the 20th century are the reasons why there are considerably fewer diseases and causes with a significant rate in total population mortality at the beginning of the 21st century. During the 1950s, there were five groups of diseases and causes which participated individually with more than 10% of population mortality (infectious diseases, heart and circulatory diseases, respiratory diseases, some perinatal conditions and undefined states) while at the beginning of the new century there were only two such groups (cardiovascular diseases and tumors). Identical trends exist in all European countries, as well as in the rest of the developed world. The leading causes of death in Serbia are cardiovascular diseases. An average of somewhat over 57.000 people died annually in the period from 2007 - 2009, which represents 55.5% of total population mortality. Women are more numerous among the deceased and this difference is increasing due to population feminization. The most frequent cause of death in Serbia, after heart and circulatory diseases, are tumors, which caused 21,415 deaths in 2009. Neoplasms are responsible for one fifth of all deaths. Their number has doubled in three decades, from 9,107 in 1975 to about 20,000 at the beginning of the 21st century, whereby tumors have become the fastest growing cause of death. Least changes in absolute number of deaths in the last half century were marked among violent deaths. Observed by gender, men are in average three times more numerous among violent deaths than women. In the middle of the 20th century in Serbia, one third of the deaths caused by violence were younger than 25 and as many as one half were younger than 35 years old. Only one tenth (11%) of total number of violent deaths were from the age group of 65 or older. At the end of the first decade of the 21st century (2009), the share of population younger than 25 in the total number of violent deaths was decreased four times (and amounted to 8%). At the same time, the rate of those older than 65 or more quadrupled (amounted to 39%).

scholarly journals Endothelium and Its Alterations in Cardiovascular Diseases: Life Style Intervention

2014 ◽  
Vol 2014 ◽  
pp. 1-28 ◽  
Author(s):  
Gaia Favero ◽  
Corrado Paganelli ◽  
Barbara Buffoli ◽  
Luigi Fabrizio Rodella ◽  
Rita Rezzani
Keyword(s):  
Endothelial Cell ◽  
Cardiovascular Diseases ◽  
Cell Activation ◽  
Cell Function ◽  
Leukocyte Adhesion ◽  
Endothelial Cell Activation ◽  
Endothelial Cell Function ◽  
Beneficial Effects ◽  
Life Style Intervention ◽  
Endothelial Functions

The endothelium, which forms the inner cellular lining of blood vessels and lymphatics, is a highly metabolically active organ that is involved in many physiopathological processes, including the control of vasomotor tone, barrier function, leukocyte adhesion, and trafficking and inflammation. In this review, we summarized and described the following: (i) endothelial cell function in physiological conditions and (ii) endothelial cell activation and dysfunction in the main cardiovascular diseases (such as atherosclerosis, and hypertension) and to diabetes, cigarette smoking, and aging physiological process. Finally, we presented the currently available evidence that supports the beneficial effects of physical activity and various dietary compounds on endothelial functions.

Ambient air pollution and cardiovascular diseases: From bench to bedside

2018 ◽  
Vol 25 (8) ◽  
pp. 818-825 ◽  
Author(s):  
Simone Vidale ◽  
Carlo Campana
Keyword(s):  
Risk Factors ◽  
Air Pollution ◽  
Cardiovascular Diseases ◽  
Air Pollutants ◽  
Causes Of Death ◽  
Ambient Air ◽  
Epidemiological Studies ◽  
Ambient Air Pollution ◽  
Particulate Matter Exposure

Air pollution has a great impact on health, representing one of the leading causes of death worldwide. Previous experimental and epidemiological studies suggested the role of pollutants as risk factors for cardiovascular diseases. For this reason, international guidelines included specific statements regarding the contribution of particulate matter exposure to increase the risk of these events. In this review, we summarise the main evidence concerning the mechanisms involved in the processes linking air pollutants to the development of cardiovascular diseases.

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