Different types of components obtained from Monascus purpureus with neuroprotective and anti-inflammatory potentials

2021 ◽  
Author(s):  
Ho-Cheng Wu ◽  
Yih-Fung Chen ◽  
Ming-Jen Cheng ◽  
Ming-Der Wu ◽  
Yen-Lin Chen ◽  
...  
Keyword(s):  
Food Additives ◽  
Monascus Purpureus ◽  
Natural Food ◽  
Asian Countries ◽  
Different Types ◽  
Anti Inflammatory

The mold Monascus has been used as the natural food coloring agent and food additives for more than 1,000 years in Asian countries. In Chinese herbology, it was also used...

scholarly journals Anti-Inflammatory Principles from the Needles of Pinus taiwanensis Hayata and In Silico Studies of Their Potential Anti-Aging Effects

Antioxidants ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 598
Author(s):  
Ping-Chung Kuo ◽  
Yue-Chiun Li ◽  
Anjar M. Kusuma ◽  
Jason T. C. Tzen ◽  
Tsong-Long Hwang ◽  
...  
Keyword(s):  
Significant Inhibition ◽  
Stable Complex ◽  
Aging Effects ◽  
Pine Needle ◽  
Ghrelin Receptor ◽  
In Silico Studies ◽  
Different Types ◽  
Ic50 Values ◽  
Bioactive Fraction ◽  
Anti Inflammatory

Pinus needle tea are very popular in Eastern countries such as Japan, Russia, Korea, and China. Pine needle tea is claimed to have significant anti-aging effects, but no clear evidence has supported this until now. In the present study, five undescribed compounds (1–5) as well as seventy-two known compounds were purified and characterized from the bioactive fraction of methanol extracts of P. taiwanensis needles. Most of the isolates were examined for their anti-inflammatory bioactivity by cellular neutrophil model and six compounds (45, 47, 48, 49, 50, and 51) exhibited a significant inhibition on superoxide anion generation and elastase release with IC50 values ranging from 3.3 ± 0.9 to 8.3 ± 0.8 μM. These anti-inflammatory ingredients were subjected to docking computing to evaluate their binding affinity on the ghrelin receptor, which played an important role in regulating metabolism, with anti-aging effects. Compounds 49, 50, and 51 formed a stable complex with the ghrelin receptor via hydrogen bonds and different types of interactions. These results suggest the flavonoids are responsible for the potential anti-aging effects of pine needle tea.

A Questionnaire-Based Survey on the Prescription of Non-Steroidal Anti-Inflammatory Drugs by Physicians in East Asian Countries in 2007

Digestion ◽  
2009 ◽  
Vol 79 (3) ◽  
pp. 177-185 ◽  
Author(s):  
Tetsuo Arakawa ◽  
Yasuhiro Fujiwara ◽  
Jose D. Sollano ◽  
Qi Zhu ◽  
Udom Kachintorn ◽  
...  
Keyword(s):  
East Asian ◽  
Asian Countries ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

An overview on therapeutic role of Diferuloylmethane (Curcumin) in Azheimer’s disease and sleep disorders

2021 ◽  
pp. 1-7
Author(s):  
Hoor Shumail ◽  
Shah Khalid ◽  
Taha Alqahtani ◽  
Mubarak Algahtany ◽  
M. Azhar Ud Din ◽  
...  
Keyword(s):  
Daily Routine ◽  
Asian Countries ◽  
Comprehensive Overview ◽  
Active Model ◽  
Progression Of Disease ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Model Drug ◽  
The Brain

Curcumin is widely used in spices in Asia. It has been widely explored for various diseases as therapeutic agent. Alzheimer’s disease (AD) is a neurodegenerative disease associated with dementia and cognitive disabilities. With the progression of disease, various changes appear in the brain cells that greatly affect the daily routine of the patient including sleep-wake disturbances. In the last few decades, extensive research has been carried out on this disease suggesting the development of non-steroidal anti-inflammatory drugs for its treatment. Since long, turmeric has been used in Asian countries as a home remedy for treating various ailments. Curcumin is an active ingredient isolated from the turmeric plant and is composed of curcuminoids. Because of its anti-inflammatory, antioxidant, anti-apoptotic and neuroprotective properties, curcumin can be safely administered to stop the progression of dementia and can be used for the development of such drugs that can reverse the neurotic damage caused by AD. This review article provides a comprehensive overview on the research carried out for AD using curcumin as active model drug.

Utilization and evaluation of Citrus natsudaidai peel waste as a source of natural food additives

2021 ◽  
pp. 131464
Author(s):  
Yu Matsuo ◽  
Kanako Akita ◽  
Honoka Taguchi ◽  
Shuji Fujii ◽  
Yumiko Yoshie-Stark ◽  
...  
Keyword(s):  
Food Additives ◽  
Natural Food

scholarly journals Research of pigments of blue-green algae spirulina platensis for practical use in confectionery technology

2019 ◽  
Vol 81 (2) ◽  
pp. 170-176
Author(s):  
T. K. Kalenik ◽  
E. V. Dobrynina ◽  
V. M. Ostapenko ◽  
Y. Torii ◽  
J. Hiromi
Keyword(s):  
Chlorophyll A ◽  
Green Algae ◽  
Spirulina Platensis ◽  
Food Additives ◽  
Water Extract ◽  
Blue Pigment ◽  
Natural Food ◽  
Synthetic Dyes ◽  
Blue Green Algae ◽  
Synthetic Origin

The article presents a study of the process of isolation of natural blue pigment – phycocyanin from the biomass of blue-green algae Spirulina platensis by water extraction, followed using its water solution as a natural food colorant in the production of milk chocolate. Recently, modern food enterprises are pursuing their policy towards expanding the range of products, which is closely related to the increasing needs of the population in food of a new kind. One of the solutions to this problem is the use of food additives of both natural and synthetic origin. Among the similar components widespread found dyes synthetic origin, which have high coverage rates and relatively low cost. However, many of the permitted in our country synthetic food dyes are banned in several developed countries as potentially dangerous to health. Synthetic dyes of red, yellow and green color have many natural analogues – carotenoids, lutein, chlorophyll, etc., except for the blue dye, the analogue of which is only anthocyanins, which are unstable depending on the pH conditions. In this article were identified phycobiliproteins and chlorophyll a in a water extract of spirulina. The mass concentration of phycobiliproteins and chlorophyll a was determined by spectrophotometric method before and after the addition of ammonium sulfate. A comparative analysis of the effect of fractionation (salting out) on the degree of purification of the phycocyanin solution. Presented and described the technological scheme of extraction of phycocyanin which allows to use it in food technologies as an extract or a dry powder. Established the concentration of phycocyanin extract from blue-green algae spirulina to produce milk blue chocolate. Determined organoleptic and hygienic characteristics of the finished product

scholarly journals Contribution of quasi-fibrillar superstructures in peroxide quenching by collagen peptides derived from fish processing by-products and their application as natural food additives

2021 ◽  
Author(s):  
K Saleem ◽  
Pritha Dey ◽  
Charitha Sumeet ◽  
Mayur Bajaj ◽  
Y Geetika ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Cultured Cells ◽  
Food Additives ◽  
Lipid Peroxide ◽  
Natural Food ◽  
Type I ◽  
Collagen Hydrolysate ◽  
Simulated Digestion ◽  
Wide Range ◽  
Fibrillar Network

AbstractThis study attempts to identify the significant role played by the secondary structure of collagen-derived peptides that are involved in lipid peroxide quenching in food products. Collagen was extracted from the skin of Perch and swim bladder of Rohu at 45-78% efficiency. It was identified as type-I based on a high molecular weight (110kDa) and its ion-exchange elution profile. The collagen samples were enzymatically hydrolyzed and collagen hydrolysate (CH) was extracted with an efficiency of 0.67-0.74g/g of collagen. The CH samples displayed a molecular weight in the range of 8.2-9.7kDa and exhibited a higher abundance of charges resulting in higher solubility. The structural studies revealed that the CH peptides existed in polyproline-II helix and formed a mimic-triple helix in a wide range of pH. In neutral and alkaline pH, the mimic helices joined to form a hierarchical quasi-fibrillar network that was smaller than collagen fibrils but also more dynamic. The CH exhibited >95% degradation in 15h through simulated digestion. The CH were able to decrease peroxide formation by 84.5-98.9% in commercially available cod liver and almond oil and increased the shelf life of soya bean oil by a factor of 5 after 6 months of storage. The addition of CH to cultured cells quenched peroxide ions generated in situ and decreased stressor activity by a factor of 12. The reason behind the high efficacy of CH was deciphered to be the proximal charge stabilization by the quasi-fibrillar network, which allowed efficient peroxide quenching and long-term stability.

Health benefits of avicularin in the medicine against cancerous disorders and other complications: Biological importance, therapeutic benefit and analytical aspects of the medicine

2021 ◽  
Vol 17 ◽  
Author(s):  
Kanika Patel ◽  
Dinesh Kumar Patel
Keyword(s):  
Data Analysis ◽  
Scientific Data ◽  
Lespedeza Cuneata ◽  
Pharmacological Activities ◽  
Medicinal Uses ◽  
Biological Importance ◽  
Anti Cancer ◽  
Scientific Data Analysis ◽  
Different Types ◽  
Anti Inflammatory

Background: Herbal drugs and their derived phytochemicals have been used in medicine for the preparation of different types of pharmaceutical products. Pure phytochemicals including flavonoids, alkaloids and terpenoids have been used in medicine for the treatment of different types of human disorders including cancerous disorders. Flavonoids have been well known in medicine for their anti-viral, anti-bacterial, anti-inflammatory, anti-diabetic, anti-cancer, anti-aging and cardioprotective potential. Avicularin, also called quercetin-3-α-l-arabino furanoside, is a pure flavonoid, a class of phytochemicals, found to be present in Lindera erythrocarpa and Lespedeza cuneata. Avicularin has been well known in medicine for its anti-cancer properties. Methods: In the present work, scientific data of avicularin have been collected from different databases such as Google, PubMed, Science Direct, Google Scholar and Scopus and summarized with reference to medicinal importance, pharmacological activities and analytical aspects of avicularin. The present review summarized the health beneficial properties of avicularin in medicine through data analysis of various scientific research works. Further analytical progress in medicine for the qualitative and quantitative analysis of avicularin in medicine has been also discussed in the present work. Results: Scientific data analysis of different literature work revealed the biological importance of flavonoid class of phytochemical ‘avicularin’ in medicine. Scientific data analysis revealed that avicularin was found to be present in the Lindera erythrocarpa, Lespedeza cuneata, Rhododendron schlipenbachii and Psidium guajava. Avicularin has been well known in medicine for its anti-inflammatory, anti-allergic, anti-oxidant, anti-tumor and hepatoprotective activities. Avicularin protects cardiomyocytes and hepatocytes against oxidative stress-induced apoptosis and induces cytotoxicity in cancer lines and tumor tissues. Avicularin has positive influence on human hepatocellular carcinoma and inhibits intracellular lipid accumulation. The role of avicularin in rheumatoid arthritis has been also established with its underlying molecular mechanisms in the scientific work. Recent interest in avicularin has focused on pharmacological investigations for its anti-cancer activity in the medicine. Conclusion: The present work signified the biological importance of avicularin in medicine through its medicinal uses, pharmacological activities and analytical aspects in the biological system.

Utilization of Agro Waste

2020 ◽  
pp. 129-159
Author(s):  
Savita Budhwar ◽  
Manali Chakraborty
Keyword(s):  
Food Security ◽  
Solid State ◽  
Rural Development ◽  
Natural Resources ◽  
Solid State Fermentation ◽  
Food Additives ◽  
Food Products ◽  
Human Consumption ◽  
Normal Human ◽  
Anti Inflammatory

Agro-wastes are one of the major sources for nutritional and therapeutic purposes along with other beneficial properties according to some ongoing studies. Yet they are not being utilized properly; instead, these wastes are being discarded in open air, causing pollution. Conservation of such natural resources is a healthy approach, and it's economic and eco-friendly. too. Novel formulated food products from these agro-wastes can be utilized as an unconventional source of nutrients and a therapeutic weapon for diseases such as diabetes, hypertension, etc. along with normal human consumption. Utilization of such agro-wastes as food products will also be useful to combat malnourished state leading to rural development and maintenance of food security in cheap prices for a healthy seeks. It also shows a possible role as antibiotics, antioxidants, anti-inflammatory agents, adsorbents, enzyme extracting sources, insulators, and food additives along with its contribution in solid state fermentation, beneficial in dairy industries.

scholarly journals Functional characterization of three flavonoid glycosyltransferases from Andrographis paniculata

2019 ◽  
Vol 6 (6) ◽  
pp. 190150 ◽  
Author(s):  
Yuan Li ◽  
Xin-Lin Li ◽  
Chang-Jiang-Sheng Lai ◽  
Rui-Shan Wang ◽  
Li-Ping Kang ◽  
...  
Keyword(s):  
Functional Characterization ◽  
Biochemical Properties ◽  
Flavonoid Glycoside ◽  
Andrographis Paniculata ◽  
Biologically Active ◽  
Flavonoid Glycosides ◽  
Asian Countries ◽  
Pharmacological Activities ◽  
Different Types

Andrographis paniculata is an important traditional medicinal herb in South and Southeast Asian countries with diverse pharmacological activities that contains various flavonoids and flavonoid glycosides. Glycosylation can transform aglycones into more stable, biologically active and structurally diverse glycosides. Here, we report three glycosyltransferases from the leaves of A. paniculata (ApUFGTs) that presented wide substrate spectra for flavonoid glycosylation and exhibited multi-site glycosylation on the substrate molecules. They acted on the 7-OH position of the A ring and were able to glycosylate several other different types of compounds. The biochemical properties and phylogenetic analysis of these glycosyltransferases were also investigated. This study provides a basis for further research on the cloning of genes involved in glycosylation from A. paniculata and offers opportunities for enhancing flavonoid glycoside production in heterologous hosts. These enzymes are expected to become effective tools for drug discovery and for the biosynthesis of derivatives via flavonoid glycosylation.

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