The preventive effect and underlying mechanism of Rhus chinensis Mill. fruits on dextran sulphate sodium-induced ulcerative colitis in mice

2021 ◽  
Author(s):  
Yi Zhang ◽  
Ou Wang ◽  
Nan Ma ◽  
Junjie Yi ◽  
Hongying Mi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ulcerative Colitis ◽  
Ethanol Extract ◽  
Underlying Mechanism ◽  
Dextran Sulphate ◽  
Tight Junction Proteins ◽  
Preventive Effect ◽  
Dextran Sulphate Sodium ◽  
Rhus Chinensis ◽  
Junction Proteins

Ethanol extract of R. chinensis fruits, rich in phenolics, alleviated DSS-induced colitis in mice by improving inflammation, oxidative stress and tight junction proteins.

scholarly journals Qingchang Wenzhong Decoction Ameliorates Dextran Sulphate Sodium-Induced Ulcerative Colitis in Rats by Downregulating the IP10/CXCR3 Axis-Mediated Inflammatory Response

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Tang-you Mao ◽  
Rui Shi ◽  
Wei-han Zhao ◽  
Yi Guo ◽  
Kang-li Gao ◽  
...  
Keyword(s):  
Gene Expression ◽  
Ulcerative Colitis ◽  
Inflammatory Response ◽  
Activity Index ◽  
Disease Activity Index ◽  
Underlying Mechanism ◽  
Dextran Sulphate ◽  
Dextran Sulphate Sodium ◽  
Rat Models ◽  
Medicine Prescription

Qingchang Wenzhong Decoction (QCWZD) is an effective traditional Chinese medicine prescription. Our previous studies have shown that QCWZD has significant efficacy in patients with mild-to-moderate ulcerative colitis (UC) and in colonic mucosa repair in UC rat models. However, the exact underlying mechanism remains unknown. Thus, this study was conducted to determine QCWZD’s efficacy and mechanism in dextran sulphate sodium- (DSS-) induced UC rat models, which were established by 7-day administration of 4.5% DSS solution. QCWZD was administered daily for 7 days, after which the rats were euthanized. Disease activity index (DAI), histological score (HS), and myeloperoxidase (MPO) level were determined to evaluate UC severity. Serum interferon gamma-induced protein 10 (IP10) levels were determined using ELISA kits. Western blotting and real-time polymerase chain reaction were, respectively, used to determine colonic protein and gene expression of IP10, chemokine (cys-x-cys motif) receptor (CXCR)3, and nuclear factor- (NF-)κB p65. Intragastric QCWZD administration ameliorated DSS-induced UC, as evidenced by decreased DAI, HS, and MPO levels. Furthermore, QCWZD decreased the protein and gene expression of IP10, CXCR3, and NF-κB p65. Overall, these results suggest that QCWZD ameliorates DSS-induced UC in rats by downregulating the IP10/CXCR3 axis-mediated inflammatory response and may be a novel UC therapy.

Stevioside, a diterpenoid glycoside, shows anti-inflammatory property against Dextran Sulphate Sodium-induced ulcerative colitis in mice

2019 ◽  
Vol 855 ◽  
pp. 192-201 ◽  
Author(s):  
Sateesh Alavala ◽  
Rajendra Sangaraju ◽  
Nasiruddin Nalban ◽  
Bidya Dhar Sahu ◽  
Mahesh Kumar Jerald ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Dextran Sulphate ◽  
Dextran Sulphate Sodium ◽  
Anti Inflammatory

scholarly journals Flaxseed oil alleviates dextran sulphate sodium-induced ulcerative colitis in rats

2020 ◽  
Vol 64 ◽  
pp. 103602 ◽  
Author(s):  
Qian Zhou ◽  
Lei Ma ◽  
Wenyang Zhao ◽  
Wen Zhao ◽  
Xue Han ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Flaxseed Oil ◽  
Dextran Sulphate ◽  
Dextran Sulphate Sodium

scholarly journals The role of zinc deficiency in alcohol-induced intestinal barrier dysfunction

2010 ◽  
Vol 298 (5) ◽  
pp. G625-G633 ◽  
Author(s):  
Wei Zhong ◽  
Craig J. McClain ◽  
Matthew Cave ◽  
Y. James Kang ◽  
Zhanxiang Zhou
Keyword(s):  
Oxidative Stress ◽  
Tight Junction ◽  
Zinc Deficiency ◽  
Barrier Function ◽  
Intestinal Barrier ◽  
Alcohol Exposure ◽  
Epithelial Barrier ◽  
Tight Junction Proteins ◽  
Barrier Dysfunction ◽  
Junction Proteins

Disruption of the intestinal barrier is a causal factor in the development of alcoholic endotoxemia and hepatitis. This study was undertaken to determine whether zinc deficiency is related to the deleterious effects of alcohol on the intestinal barrier. Mice were pair fed an alcohol or isocaloric liquid diet for 4 wk, and hepatitis was detected in association with elevated blood endotoxin level. Alcohol exposure significantly increased the permeability of the ileum but did not affect the barrier function of the duodenum or jejunum. Reduction of tight-junction proteins at the ileal epithelium was detected in alcohol-fed mice although alcohol exposure did not cause apparent histopathological changes. Alcohol exposure significantly reduced the ileal zinc concentration in association with accumulation of reactive oxygen species. Caco-2 cell culture demonstrated that alcohol exposure increases the intracellular free zinc because of oxidative stress. Zinc deprivation caused epithelial barrier disruption in association with disassembling of tight junction proteins in the Caco-2 monolayer cells. Furthermore, minor zinc deprivation exaggerated the deleterious effect of alcohol on the epithelial barrier. In conclusion, epithelial barrier dysfunction in the distal small intestine plays an important role in alcohol-induced gut leakiness, and zinc deficiency attributable to oxidative stress may interfere with the intestinal barrier function by a direct action on tight junction proteins or by sensitizing to the effects of alcohol.

Preventive effect of carob (Ceratonia siliqua L.) in dextran sulfate sodium-induced ulcerative colitis in rat

RSC Advances ◽  
2016 ◽  
Vol 6 (24) ◽  
pp. 19992-20000 ◽  
Author(s):  
Kaïs Rtibi ◽  
Mohamed-Amine Jabri ◽  
Slimen Selmi ◽  
Hichem Sebai ◽  
Jean-Claude Marie ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ulcerative Colitis ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Gastrointestinal Diseases ◽  
Common Mechanism ◽  
Ceratonia Siliqua ◽  
Preventive Effect ◽  
Ceratonia Siliqua L ◽  
And Oxidative Stress

Inflammation and oxidative stress are a common mechanism of many gastrointestinal diseases such ulcerative colitis.

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