The role of metabolites of steviol glycosides and their glucosylated derivatives against diabetes-related metabolic disorders

2021 ◽  
Author(s):  
Yuqi Li ◽  
wanfang zhu ◽  
Jing Cai ◽  
Wenyuan Liu ◽  
Toshihiro Akihisa ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Secretion ◽  
Protein Metabolism ◽  
Metabolic Disorder ◽  
Metabolic Disorders ◽  
Target Cells ◽  
Steviol Glycosides

Diabetes mellitus (DM), characterized by abnormal carbohydrate, lipid, and protein metabolism, is a metabolic disorder caused by shortage of insulin secretion or decreased sensitivity of target cells to insulin. In...

Role of Rhizome Powder of Turmeric in the management of Madhumeha w.s.r. to Diabetes Mellitus - A Case Study

2017 ◽  
Vol 2 (2) ◽  
Author(s):  
Krup Vasavda ◽  
Hegde Prakash L ◽  
Harini A.
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Secretion ◽  
Protein Metabolism ◽  
Metabolic Disorder ◽  
Metabolic Disorders ◽  
Single Drug ◽  
Chronic Hyperglycemia ◽  
Relative Deficiency

Diabetes mellitus is a group of metabolic disorders characterized by chronic hyperglycemia associated with disturbances of carbohydrates, fat, protein metabolism due to absolute or relative deficiency in insulin secretion, that metabolic disorder is considered as the Madhumeha in Ayurveda based on their symptoms. It is one of the types of Vataja Prameha. It results from various etiological factors. Here objective was to evaluate the efficacy of Ayurveda treatment in management of Madhumeha. A 35years old male came to SDM College of Ayurveda Hospital Kayachikitsa special OPD with complaint of Prabhoothamutra, Karapada Daha, Avila Mutrata and Kshudaathi Pravrthi. Examination, investigations and history leads to diabetes mellitus. So patient was treated with Haridra Choorna, Pathya, Apathya and Yogasananas. Ayurveda treatment has effective results in the management of Madhumeha by single drug administration orally.

scholarly journals The Role of Ethnomedicinal Plants for Treatment and Management of Diabetes Mellitus: An Updated Review

2021 ◽  
Vol 23 (07) ◽  
pp. 1014-1049
Author(s):  
Rakesh K Sindhu ◽  
◽  
Balraj Saini ◽  
Prabhjot Kaur ◽  
Gaber El-Saber Batiha ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Secretion ◽  
Blood Glucose ◽  
Pancreatic Islets ◽  
Bioactive Compounds ◽  
Metabolic Disorders ◽  
Review Article ◽  
Treatment Mode ◽  
Significant Treatment

Diabetes mellitus is one of the prominent metabolic disorders nowadays worldwide and it is characterized by an increase in blood glucose, disturbances in metabolism, and alteration in insulin secretion. Nowadays, phytopharmaceuticals have become a significant treatment mode for diabetes, and bioactive compounds have expanded an increasing amount of consideration to this end for they have multiple biological potentials, including the sustained secretion of insulin and revival of pancreatic islets cells. In this review article, we explained the role of bioactive compounds in the treatment and management of diabetes and their mechanisms in prevention.

A Critical Review on Madhumeha (Diabetes Mellitus) with its Preventive Approach

2017 ◽  
Vol 2 (05) ◽  
Author(s):  
Anagha Gosavi ◽  
Ram V. Ramekar
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Secretion ◽  
Protein Metabolism ◽  
Insulin Action ◽  
Preventive Measures ◽  
Sweet Taste ◽  
Whole Body ◽  
Appropriate Use ◽  
Chronic Hyperglycemia ◽  
Therapeutic Measures

Prameha is disease of Mutravaha Srotasa having Kapha dominancy which can be correlated with diabetes mellitus. The term diabetes mellitus describes a metabolic disorder of multiple etiologies characterized by chronic hyperglycemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both. Madhumeha is considered as a subtype under the Vatika type of Prameha and it is characterized by passage of urine with sweet taste like honey along with sweetness of whole body. With appropriate use of Ayurvedic preventive measures such as Dincharya, Ritucharya, Aharvidhi and therapeutic measures Madhumeha (DM) can be prevented.

scholarly journals Association Study of Candidate Gene Uncoupling Protein 2 (UCP2) with Type 2 Diabetes Mellitus in the Different Population Groups of Jammu Region

2019 ◽  
Vol 16 (2) ◽  
pp. 351-357
Author(s):  
Sunil Raina ◽  
Roopali Fotra
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Disorders ◽  
Uncoupling Protein ◽  
Molecular Genetic ◽  
Promoter Polymorphism ◽  
Uncoupling Protein 2 ◽  
Population Groups ◽  
Allelic Odds Ratio

Diabetes Mellitus is a group of metabolic disorders characterized by hyperglycaemic resulting from the defects of insulin secretion, insulin action or both. The present study was conducted in order to know the molecular genetic cause of the T2DM patients belonging to the Jammu region of J&K State. Many genes have been known to be linked with the onset and progression of the T2DM therefore the present data represents the role of one of the genes Uncoupling protein 2 (UCP2) known to be strongly associated with T2DM was selected. A total of 250 confirmed cases & controls samples belonging to four population groups (Hindu, Muslim, Sikh & Christians) of Jammu region were also screened for UCP2 -866G/A promoter polymorphism (rs659366). The allelic odds ratio (OR) as observed for UCP2 -866G/A polymorphism in the four population groups showed significant association with Muslim & Sikh population groups. The study undertaken supports the findings of the previous investigations and thus is an addition to the existing literatute in support of UCP2 and T2DM.

scholarly journals Family's Ability to Take Care The Patient of Type 2 Diabetes Mellitus in Tasikmalaya

2020 ◽  
Vol 3 (3) ◽  
pp. 150
Author(s):  
Bayu Brahmantia ◽  
Miftahul Falah ◽  
Lilis Lismayanti ◽  
Vina Erviana
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Health Education ◽  
Blood Sugar ◽  
Metabolic Disorder ◽  
Sampling Method ◽  
The Family

Diabetes Mellitus is a metabolic disorder disease characterized by a rise of blood sugar due to a decrease of insulin by the pancreas. The role of the family in caring for the patient with type 2 diabetes mellitus is crucial in treatment. this study was aimed to know the ability of family in caring. a purposive sampling method was applied in this research. a total of 31 respondents were selected. the results showed that the majority of family's ability to recognize as a problem was good with 16 people ( 51,6 % ), in taking decisions for treatment was positive as much as 19 people (61.3%), in treatment of type 2 Diabetes Mellitus patients were positive 25 people (80,6%), in modifying the environment for Treatment was negative  18 people (58.1%). therefore, Health education for the family related to modifying the environment for treatment was required to recover the patient.

scholarly journals The role of innate lymphoid cells in selected disease states – cancer formation, metabolic disorder and inflammation

2021 ◽  
Vol 17 (1) ◽  
pp. 196-206
Author(s):  
Agata Poniewierska-Baran ◽  
Beata Tokarz-Deptuła ◽  
Wiesław Deptuła
Keyword(s):  
Human Body ◽  
Immune Cells ◽  
Metabolic Disorder ◽  
Metabolic Disorders ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Medical Community ◽  
Disease States ◽  
Disease Diagnostics

Innate lymphoid cells (ILCs) are a recently described group of immune cells that can regulate homeostasis and protect mammalian organisms, including humans, from infections and diseases. Considering this, ILC research is still ongoing to better understand the biology of these cells and their roles in the human body. ILCs are a multifunctional group of immune cells, making it important for the medical community to be familiar with the latest research about the ILC families and their functions in selected disease states, such as cancer formation, metabolic disorders and inflammation. By discovering the roles of ILC populations and their participation in many disorders, we can improve disease diagnostics and patient healthcare.

Uncommon Association Between Diabetic Ketoacidosis, Thyrotoxicosis, Cutaneous Abscess and Acute Pericarditis in an Immunocompetent Patient: A Single Case Report and Literature Review

2020 ◽  
Vol 16 (6) ◽  
pp. 641-648
Author(s):  
Martinot Amelie ◽  
Demar Magalie ◽  
Thelusme Liliane ◽  
Bounoua Merzaka ◽  
Santa Florin ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Case Report ◽  
Diabetic Ketoacidosis ◽  
Metabolic Disorders ◽  
Single Case ◽  
Immunocompetent Patient ◽  
Acute Pericarditis ◽  
Single Case Report

Introduction : The typical factors precipitating diabetic ketoacidosis (DKA) include infections (30%), cessation of antidiabetic medication (20%), and a new diagnosis of diabetes (25%). The etiology remains unknown in 25% of cases. Less frequent causes cited in the literature include severe thyrotoxicosis and, infrequently, pericarditis. Few publications have described the role of human T lymphotropic virus type 1 (HTLV-1) in endocrine and metabolic disorders. Based on a clinical case associated with several endocrine and metabolic disorders, we suggest a potential role for HTLV-1, an endemic virus in the Amazonian area, and review the literature concerning the role of this virus in thyroiditis, pericarditis and diabetes mellitus. Case Report : A fifty-year-old Surinamese woman without any medical history was admitted for diabetic ketoacidosis. No specific anti-pancreatic autoimmunity was observed, and the C-peptide level was low, indicating atypical type-1 diabetes mellitus. DKA was associated with thyrotoxicosis in the context of thyroiditis and complicated by nonbacterial pericarditis and a Staphylococcus aureus subcutaneous abscess. The patient was infected with HTLV-1. Conclusion: To our knowledge, this uncommon association is described for the first time. Few studies have analyzed the implications of HTLV-1 infection in thyroiditis and diabetes mellitus. We did not find any reports describing the association of pericarditis with HTLV-1 infection. Additional studies are necessary to understand the role of HTLV-1 in endocrine and cardiac disorders.

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