Structural characteristic of Gracilaria lemaneiformis oligosaccharides and its alleviation of dextran sulphate sodium-induced colitis by modulating the gut microbiota and intestinal metabolite in mice

2021 ◽  
Author(s):  
Xuting Xie ◽  
Lixin Zheng ◽  
Huimin Duan ◽  
Yang Liu ◽  
Kit Leong Cheong ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Gut Microbiota ◽  
Disease Control ◽  
Structural Characteristic ◽  
Functional Food ◽  
Good Option ◽  
Gracilaria Lemaneiformis ◽  
Dextran Sulphate ◽  
Dextran Sulphate Sodium ◽  
High Incidence

Ulcerative colitis (UC) is a chronic lifetime disorder with a high incidence worldwide. A functional food-based method to prevent UC would be a good option for disease control. G. lemaneiformis...

scholarly journals Gut Microbiota-Mediated NLRP12 Expression Drives the Attenuation of Dextran Sulphate Sodium-Induced Ulcerative Colitis by Qingchang Wenzhong Decoction

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Zhongmei Sun ◽  
Wenjing Pei ◽  
Yi Guo ◽  
Zhibin Wang ◽  
Rui Shi ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Gut Microbiota ◽  
Clinical Symptoms ◽  
Intestinal Barrier ◽  
Intestinal Barrier Function ◽  
Dextran Sulphate ◽  
16S Rrna Analysis ◽  
Dextran Sulphate Sodium ◽  
Regulatory Effects ◽  
The Relationship

Qingchang Wenzhong Decoction (QCWZD) is a newly developed, effective traditional Chinese herbal formulation for ulcerative colitis (UC). In earlier studies, we found that QCWZD could relieve the clinical symptoms of UC patients, reduce inflammation, and improve the intestinal barrier function in dextran sulphate sodium (DSS)-induced UC rats. However, the relationship between QCWZD and the gut microbiota in colitis was not clarified. In this study, we established a rat model of DSS-induced UC and then investigated the regulatory effects of QCWZD on the gut microbiota using 16S rRNA analysis. We also determined the expression of NLRP12 after QCWZD administration. Our findings suggested that QCWZD administration could modulate gut microbiota composition and selectively promote the protective strains such asButyricimonas,Blautia,andOdoribacter,whereas the enteric pathogens includingClostridiumandDoreawere significantly reduced after QCWZD treatment. It is noteworthy that QCWZD administration was identified to promote gut microbiota-mediated NLRP12 expression by inhibiting the activity of the TLR4/Blimp-1 axis. In conclusion, our study supports the potential of QCWZD administration as a beneficial therapeutic strategy for UC.

Stevioside, a diterpenoid glycoside, shows anti-inflammatory property against Dextran Sulphate Sodium-induced ulcerative colitis in mice

2019 ◽  
Vol 855 ◽  
pp. 192-201 ◽  
Author(s):  
Sateesh Alavala ◽  
Rajendra Sangaraju ◽  
Nasiruddin Nalban ◽  
Bidya Dhar Sahu ◽  
Mahesh Kumar Jerald ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Dextran Sulphate ◽  
Dextran Sulphate Sodium ◽  
Anti Inflammatory

scholarly journals Flaxseed oil alleviates dextran sulphate sodium-induced ulcerative colitis in rats

2020 ◽  
Vol 64 ◽  
pp. 103602 ◽  
Author(s):  
Qian Zhou ◽  
Lei Ma ◽  
Wenyang Zhao ◽  
Wen Zhao ◽  
Xue Han ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Flaxseed Oil ◽  
Dextran Sulphate ◽  
Dextran Sulphate Sodium

scholarly journals Slimy partners: the mucus barrier and gut microbiome in ulcerative colitis

2021 ◽  
Author(s):  
Jian Fang ◽  
Hui Wang ◽  
Yuping Zhou ◽  
Hui Zhang ◽  
Huiting Zhou ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Gut Microbiota ◽  
Gut Microbiome ◽  
Onset Age ◽  
Intestinal Microbes ◽  
Inflammatory Damage ◽  
Bidirectional Communication ◽  
High Incidence ◽  
Mucus Barrier ◽  
Intestinal Inflammatory Disease

AbstractUlcerative colitis (UC) is a chronic recurrent intestinal inflammatory disease characterized by high incidence and young onset age. Recently, there have been some interesting findings in the pathogenesis of UC. The mucus barrier, which is composed of a mucin complex rich in O-glycosylation, not only provides nutrients and habitat for intestinal microbes but also orchestrates the taming of germs. In turn, the gut microbiota modulates the production and secretion of mucins and stratification of the mucus layers. Active bidirectional communication between the microbiota and its ‘slimy’ partner, the mucus barrier, seems to be a continually performed concerto, maintaining homeostasis of the gut ecological microenvironment. Any abnormalities may induce a disorder in the gut community, thereby causing inflammatory damage. Our review mainly focuses on the complicated communication between the mucus barrier and gut microbiome to explore a promising new avenue for UC therapy.

Induction of ulcerative colitis in mice influences the course of infection with the nematode Trichuris muris

2014 ◽  
Vol 89 (5) ◽  
pp. 593-600 ◽  
Author(s):  
M.C. Vegas-Sánchez ◽  
E. Rollán-Landeras ◽  
J.J. García-Rodríguez ◽  
F. Bolás-Fernández
Keyword(s):  
Ulcerative Colitis ◽  
Concurrent Infection ◽  
Dextran Sulphate ◽  
Oral Gavage ◽  
Acute Colitis ◽  
Trichuris Muris ◽  
Dextran Sulphate Sodium ◽  
Beneficial Effects ◽  
Chemically Induced ◽  
Inflammatory Bowel

AbstractThe aim of this study was to assess the effect of infection with the nematode whipworm Trichuris muris on the course of chemically induced acute ulcerative colitis in CBA/J mice, a strain proven to be highly resistant to infection with T. muris. Each mouse was infected with 50 embryonated eggs of T. muris by oral gavage. Acute colitis was triggered by administering 4% dextran sulphate sodium (DSS) in the drinking water for nine consecutive days at different times after infection. Concurrent infection and DSS administration exacerbate the severity of the colitis while favouring the permanence of parasites in the intestine. The induction of ulcerative colitis from days 54 to 62 post-infection (p.i.), when all worms had been expelled, ameliorated the course of the inflammatory disease. When ulcerative colitis was triggered earlier on, from days 27 to 35 p.i., the beneficial effects on inflammatory events were clearly shown with signs of mucosal epithelization and regeneration as early as day 1 after DSS administration. Previous infections by T. muris therefore accelerate recovery from subsequently induced inflammatory bowel disease and such an effect assists the nematode to persist in the intestinal niche.

scholarly journals Maggot protein ameliorates dextran sulphate sodium-induced ulcerative colitis in mice

2018 ◽  
Vol 38 (6) ◽  
Author(s):  
Rong Wang ◽  
Lei Wang ◽  
Yongzheng Luo ◽  
Daojuan Wang ◽  
Ronghui Du ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Activity Index ◽  
Water Model ◽  
Inflammatory Factors ◽  
Control Group ◽  
Sterile Water ◽  
Dextran Sulphate ◽  
Model Group ◽  
Dextran Sulphate Sodium ◽  
Body Weights

Ulcerative colitis (UC) is a common chronic remitting disease but without satisfactory treatment. Maggots are known as a traditional Chinese medicine named as ‘wu gu chong’. The aim of the present study was to investigate the therapeutic effect of the maggot protein on dextran sulphate sodium (DSS)-induced colitis in C57BL/6 mice. In the present study, female C57BL/6 mice were given sterile water containing 3% DSS to establish the model of UC. Mice were randomly divided into five groups: control group (sterile water), model group (DSS), treatment group (DSS + maggot protein), mesalazine group (DSS + mesalazine), and maggot protein group (sterile water + maggot protein). The mental state, defecate traits, and changes in body weights were recorded daily. The disease activity index (DAI) as a disease severity criterion was calculated based on body weights and stool consistency and bleeding. All the mice were killed on the 12th day. Colon length, colon histological changes, and other inflammatory factors were analyzed and evaluated. The results showed that colitis models of mice were established successfully. Administration of maggot protein markedly suppressed the severity of UC compared with the DSS model group. Furthermore, maggot protein potently ameliorated DSS-induced weight loss, colon shortening, and colon histological injury. Moreover, the maggot protein exerted anti-inflammatory effects via inhibition of the activation of the nuclear factor κB (NFκB) signaling pathway. In summary, treatment by maggot protein was able to improve not only the symptoms of colitis, but also the microscopic inflammation in mice with DSS-induced colitis. The present study may have implications for developing an effective therapeutic strategy for inflammatory bowel diseases (IBDs).

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