Generation and reactivity of an elusive base-stabilised phosphinidene

2021 ◽  
Author(s):  
Minh Tho Nguyen ◽  
Brandon White ◽  
Denis M Spasyuk ◽  
Travis Dudding ◽  
Georgii I. Nikonov
Keyword(s):  
Reactive Intermediate

Reduction of phosphorus dichloride 6, supported by the diaryloxyphenyl group (OCO) featuring two bulky phenoxy wingtips, by PMe3, generates a reactive intermediate that behaves as a base-stabilized phosphinidene (OCO)P (5)....

Mechanism of the propagation step in the anionic polymerization of styrene

1980 ◽  
Vol 45 (4) ◽  
pp. 1047-1055 ◽  
Author(s):  
Miroslav Kašpar ◽  
Jiří Trekoval
Keyword(s):  
Experimental Data ◽  
Induction Period ◽  
Anionic Polymerization ◽  
Reactive Intermediate ◽  
Coordination Polymerization ◽  
Kinetic Dependence ◽  
Mathematical Solution ◽  
Slow Reaction

The paper is dealing with an investigation of the kinetic dependence of the propagation step in the anionic coordination polymerization of styrene in benzene at 303 K with "living" oligostyryllithium as initiator at the onset of the reaction. A short but distinct induction period was found, indicating a preceding slow reaction leading to the formation of a reactive intermediate, which behaves as the initiator of the reaction. Using results obtained in the first paper of this series, a new mechanism of propagation has been suggested, the mathematical solution of which is correlated with experimental data.

scholarly journals Evidence for a Negative Correlation between Human Reactive Enamine-Imine Intermediate Deaminase A (RIDA) Activity and Cell Proliferation Rate: Role of Lysine Succinylation of RIDA

2021 ◽  
Vol 22 (8) ◽  
pp. 3804
Author(s):  
Luisa Siculella ◽  
Laura Giannotti ◽  
Benedetta Di Chiara Stanca ◽  
Matteo Calcagnile ◽  
Alessio Rochira ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cell Lines ◽  
Negative Correlation ◽  
Cancer Biology ◽  
Human Tumor ◽  
In Silico Analysis ◽  
Proliferation Rate ◽  
Reactive Intermediate ◽  
Cell Proliferation Rate

Reactive intermediate deaminase (Rid) proteins are enzymes conserved in all domains of life. UK114, a mammalian member of RidA subfamily, has been firstly identified as a component of liver perchloric acid-soluble proteins (L-PSP). Although still poorly defined, several functions have been attributed to the mammalian protein UK114/RIDA, including the reactive intermediate deamination activity. The expression of UK114/RIDA has been observed in some tumors, arousing interest in this protein as an evaluable tumor marker. However, other studies reported a negative correlation between UK114/RIDA expression, tumor differentiation degree and cell proliferation. This work addressed the question of UK114/RIDA expression in human non-tumor HEK293 cell lines and in some human tumor cell lines. Here we reported that human RIDA (hRIDA) was expressed in all the analyzed cell line and subjected to lysine (K-)succinylation. In HEK293, hRIDA K-succinylation was negatively correlated to the cell proliferation rate and was under the control of SIRT5. Moreover, K-succinylation clearly altered hRIDA quantification by immunoblotting, explaining, at least in part, some discrepancies about RIDA expression reported in previous studies. We found that hRIDA was able to deaminate reactive enamine-imine intermediates and that K-succinylation drastically reduced deaminase activity. As predicted by in silico analysis, the observed reduction of deaminase activity has been related to the drastic alterations of hRIDA structure inferred by K-succinylation. The role of hRIDA and the importance of its K-succinylation in cell metabolism, especially in cancer biology, have been discussed.

Carbene radical anions. New species of reactive intermediate

1972 ◽  
Vol 94 (20) ◽  
pp. 7174-7176 ◽  
Author(s):  
G. Dann Sargent ◽  
Charles M. Tatum ◽  
Scott M. Kastner
Keyword(s):  
New Species ◽  
Radical Anions ◽  
Reactive Intermediate

Reaction of o-phenylenediamine with dibenzoylethylene and dibenzoylacetylene. isolation of a reactive intermediate

1975 ◽  
Vol 16 (25) ◽  
pp. 2073-2076 ◽  
Author(s):  
R.G. Bass ◽  
D.D. Crichton ◽  
Harriet K. Meetz ◽  
Ashby F. Johnson
Keyword(s):  
Reactive Intermediate

Semiempirical description of the C6H5N reactive intermediate in phenyl azide photolysis

1976 ◽  
Vol 43 (2) ◽  
pp. 137-144 ◽  
Author(s):  
Donald D. Shillady ◽  
Carl Trindle
Keyword(s):  
Reactive Intermediate ◽  
Phenyl Azide

Mechanism for the direct synthesis of tryptophan from indole and serine: a useful NMR technique for the detection of a reactive intermediate in the reaction mixture

2010 ◽  
Vol 48 (10) ◽  
pp. 811-817 ◽  
Author(s):  
Yuusaku Yokoyama ◽  
Masamichi Nakakoshi ◽  
Hiroaki Okuno ◽  
Yohko Sakamoto ◽  
Satoshi Sakurai
Keyword(s):  
Direct Synthesis ◽  
Reactive Intermediate
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