Unprecedented Copper(II) Coordination Induced Nucleophilic Cleavage of Quinoxaline Heterocycle: Structural and Computational Studies

CrystEngComm ◽  
2021 ◽  
Author(s):  
Bhaskar Biswas ◽  
Nilaj Banerjee ◽  
Mayank Joshi ◽  
Stevan Armaković ◽  
Sanja J Armaković ◽  
...  
Keyword(s):  
Synthetic Approach ◽  
Computational Studies ◽  
Quinoxaline Derivative ◽  
Catalyst Free ◽  
Nucleophilic Cleavage

A straightforward catalyst-free synthetic approach has been developed for the synthesis of quinoxaline derivative, 4-phenyl-4-(pyridin-2-yl)-4,5-dihydropyrrolo[1,2-a]quinoxaline (L) by the reaction of 2-benzoyl pyridine and pyrrole-1-anillin in ethanol. The L in presence...

Diversity-Oriented Synthesis via Catalyst-Free Addition of Ketones to [e]-Fused 1H-Pyrrole-2,3-diones

Synthesis ◽  
2018 ◽  
Vol 50 (24) ◽  
pp. 4897-4904 ◽  
Author(s):  
Ekaterina Stepanova ◽  
Andrey Maslivets ◽  
Svetlana Kasatkina ◽  
Maksim Dmitriev
Keyword(s):  
Intramolecular Cyclization ◽  
Aromatic Hydrocarbons ◽  
Michael Addition ◽  
Aldol Reaction ◽  
Synthetic Approach ◽  
Reaction Conditions ◽  
Diversity Oriented Synthesis ◽  
Catalyst Free ◽  
Solvent Free Conditions ◽  
Reaction Proceeds

A facile synthetic approach towards two distinct pyrrole-based heterocyclic scaffolds has been developed by the interaction of 1H-pyrrole-2,3-diones fused at the [e]-side to a 1,4-benzoxazin-2-one or quinoxalin-2(1H)-one moiety with ketones. The described interaction proceeds either as an aldol reaction or as a Michael addition/intramolecular cyclization depending on the reaction conditions. The disclosed aldol reaction proceeds with good diastereoselectivity under catalyst-free conditions when the reaction is carried out in aromatic hydrocarbons. Products of the cascade Michael addition/intramolecular cyclization reaction are predominantly formed under catalyst-free and solvent-free conditions. The proposed strategy provides facile access to pharmaceutically interesting pyrrole-based polyheterocycles.

Computational studies of catalyst-free single walled carbon nanotube growth

2013 ◽  
Vol 139 (5) ◽  
pp. 054308 ◽  
Author(s):  
S. Haghighatpanah ◽  
A. Mohsenzadeh ◽  
H. Amara ◽  
C. Bichara ◽  
K. Bolton
Keyword(s):  
Carbon Nanotube ◽  
Computational Studies ◽  
Single Walled Carbon Nanotube ◽  
Single Walled Carbon ◽  
Catalyst Free ◽  
Carbon Nanotube Growth ◽  
Nanotube Growth

scholarly journals Reaction of Glycerol with Trimethyl Orthoformate: Towards the Synthesis of New Glycerol Derivatives

Catalysts ◽  
2019 ◽  
Vol 9 (6) ◽  
pp. 534 ◽  
Author(s):  
Roberto Calmanti ◽  
Emanuele Amadio ◽  
Alvise Perosa ◽  
Maurizio Selva
Keyword(s):  
Ionic Liquids ◽  
Lewis Acid ◽  
Synthetic Approach ◽  
Acid Catalysts ◽  
Lewis Acid Catalysts ◽  
Catalyst Free ◽  
Acidic Ionic Liquids ◽  
Brønsted And Lewis Acid ◽  
Trimethyl Orthoformate

The reactivity of glycerol with trimethyl orthoformate is here described with an emphasis on developing a reliable synthetic approach for glycerol valorization. The glycerol based orthoester 4-(dimethoxymethoxy)methyl)-2-methoxy-1,3-dioxolane (3) was synthesized, under catalytic as well as catalyst-free conditions, by taking advantage of the thermodynamically controlled equilibrium between intermediates. Both Brønsted and Lewis acid catalysts accelerated the attainment of such an equilibrium, particularly Brønsted acidic ionic liquids BSMImHSO4 and BSMImBr were the most effective compounds for this reaction. The kinetic profiles allowed the proposal of a mechanism that accounts for the selectivity of the reaction.

scholarly journals Catalyst-free four-component domino synthetic approach toward versatile multicyclic spirooxindole pyran scaffolds

RSC Advances ◽  
2019 ◽  
Vol 9 (29) ◽  
pp. 16525-16533 ◽  
Author(s):  
Aref Mohammadi ◽  
Mohammad Bayat ◽  
Shima Nasri
Keyword(s):  
Synthetic Approach ◽  
Catalyst Free ◽  
Active Methylene Compounds ◽  
Active Methylene

Synthesis of spirooxindole pyrans by a sequential four-component reaction of nitroketene dithioacetals, alkylamine/benzylamine, isatin, and active methylene compounds.

Metal catalyst free one-pot synthesis of 2-arylbenzimidazoles from α-aroylketene dithioacetals

RSC Advances ◽  
2014 ◽  
Vol 4 (23) ◽  
pp. 12028-12036 ◽  
Author(s):  
Pandi Dhanalakshmi ◽  
Solaimalai Thimmarayaperumal ◽  
Sivakumar Shanmugam
Keyword(s):  
Metal Catalyst ◽  
Synthetic Approach ◽  
One Pot ◽  
Catalyst Free ◽  
One Pot Synthesis

An efficient green synthetic approach has been developed towards the synthesis of 2-aryl substituted benzimidazoles 4 from α-aroylketene dithioacetals (AKDTAs) 1 and phenylenediamine (OPD) 2.

An Effective Approach to 1,2,3-Triazole-Containing 12-Vertex closo-Dodecaborates

2007 ◽  
Vol 72 (12) ◽  
pp. 1717-1724 ◽  
Author(s):  
Andrey A. Semioshkin ◽  
Sergey N. Osipov ◽  
Julia N. Grebenyuk ◽  
Evgueniya A. Nizhnik ◽  
Ivan A. Godovikov ◽  
...  
Keyword(s):  
Dipolar Cycloaddition ◽  
Synthetic Approach ◽  
Wide Range ◽  
Nucleophilic Cleavage

An efficient general synthetic approach giving a facile, rapid and inexpensive access to a wide range of novel 1,2,3-triazoles bearing closo-dodecaborate fragment has been developed. The method is based on the nucleophilic cleavage of oxonium dodecaborate with NaN3 or tertiary propargylamine and subsequent Huisgen 1,3-dipolar cycloaddition ("click" methodology) of the cleavage products and organic acetylenes or azides.

ChemInform Abstract: One-Step Synthesis of Alkyl 2-Chloropyrimido[1,2-a]benzimidazole-3-carboxylates under Catalyst-Free: Combined Experimental and Computational Studies.

ChemInform ◽  
2015 ◽  
Vol 46 (49) ◽  
pp. no-no
Author(s):  
Yang Liu ◽  
Guoming Xia ◽  
Chao Luo ◽  
Jianqi Sun ◽  
Benfei Ye ◽  
...  
Keyword(s):  
Computational Studies ◽  
Catalyst Free ◽  
One Step

A green synthetic approach toward the synthesis of structurally diverse spirooxindole derivative libraries under catalyst-free conditions

2017 ◽  
Vol 21 (2) ◽  
pp. 325-337 ◽  
Author(s):  
Nazia Kausar ◽  
Abdulla Al Masum ◽  
Md. Maidul Islam ◽  
Asish R. Das
Keyword(s):  
Synthetic Approach ◽  
Catalyst Free
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