scholarly journals Catalyst-free four-component domino synthetic approach toward versatile multicyclic spirooxindole pyran scaffolds

RSC Advances ◽  
2019 ◽  
Vol 9 (29) ◽  
pp. 16525-16533 ◽  
Author(s):  
Aref Mohammadi ◽  
Mohammad Bayat ◽  
Shima Nasri
Keyword(s):  
Synthetic Approach ◽  
Catalyst Free ◽  
Active Methylene Compounds ◽  
Active Methylene

Synthesis of spirooxindole pyrans by a sequential four-component reaction of nitroketene dithioacetals, alkylamine/benzylamine, isatin, and active methylene compounds.

scholarly journals A Facile and Catalyst-Free Microwave-Promoted Multicomponent Reaction for the Synthesis of Functionalised 1,4-Dihydropyridines With Superb Selectivity and Yields

2021 ◽  
Vol 9 ◽  
Author(s):  
Nagaraju Kerru ◽  
Suresh Maddila ◽  
Sreekantha B. Jonnalagadda
Keyword(s):  
Spectroscopic Analysis ◽  
High Selectivity ◽  
Water Medium ◽  
One Pot ◽  
Green Protocol ◽  
Catalyst Free ◽  
Active Methylene Compounds ◽  
The One ◽  
Pyrimidine Analogs ◽  
Active Methylene

We report a highly efficient green protocol for developing a novel library of 1,2,4-triazole-tagged 1,4-dihydropyridine analogs through the one-pot process from the four-component fusion of the 1H-1,2,4-triazol-3-amine with different chosen aldehydes, diethyl acetylenedicarboxylate, and active methylene compounds in a water medium under microwave irradiation and catalyst-free conditions. Excellent yields (94–97%) of the target products were achieved with high selectivity with a short reaction time (<12 min) at room temperature. The structures of the synthesized pyrimidine analogs were established by NMR and HRMS spectroscopic analysis. Simple workup, impressive yields, no column chromatography, green solvent, rapid reaction, and excellent functional group tolerance are the benefits of this protocol.

scholarly journals A new and facile synthetic approach to substituted 2-thioxoquinazolin-4-ones by the annulation of a pyrimidine derivative

2010 ◽  
Vol 6 ◽  
pp. 1056-1060 ◽  
Author(s):  
Nimalini Devi Moirangthem ◽  
Warjeet Singh Laitonjam
Keyword(s):  
Ethyl Cyanoacetate ◽  
Pyrimidine Derivative ◽  
Synthetic Approach ◽  
Facile Synthesis ◽  
Benzenoid System ◽  
Active Methylene Compounds ◽  
Pyrimidine Moiety ◽  
Derivatives Of ◽  
Active Methylene

A new and facile synthesis of 2-thioxoquinazolin-4-ones by introducing a benzenoid system in the pyrimidine moiety by reacting ethoxymethylene derivatives of 1,3-diarylthiobarbituric acids (DTBA) with active methylene compounds, such as malononitrile and ethyl cyanoacetate, in presence of ZnCl2 has been developed.

scholarly journals Application of Commercially Available Anhydrous Potassium Fluoride for a Convenient Synthesis of Ketene Dithioacetals

1999 ◽  
Vol 23 (8) ◽  
pp. 492-493
Author(s):  
Sabir H. Mashraqui ◽  
Harini Hariharasubrahmanian
Keyword(s):  
Carbon Disulfide ◽  
Alkylating Agent ◽  
Potassium Fluoride ◽  
Solid Support ◽  
Ambient Conditions ◽  
Ketene Dithioacetals ◽  
Convenient Synthesis ◽  
Active Methylene Compounds ◽  
Active Methylene

Commercially available anhydrous KF without activation or solid support promotes condensation between active methylene compounds, carbon disulfide and an alkylating agent in dry DMF to allow the preparation of a variety of ketene dithioacetals in fair to good yields under ambient conditions.

The Copper-catalyzed Chemoselective Monoalkylation of Active Methylene Compounds with Alkylsilyl Peroxides

2021 ◽  
Author(s):  
Jiamin Lv ◽  
Weiping Xu ◽  
Hanbin Lu ◽  
Terumasa Kato ◽  
Yan Liu ◽  
...  
Keyword(s):  
Active Methylene Compounds ◽  
Novel Method ◽  
Active Methylene

A novel method for a mild copper-catalyzed chemoselective monoalkylation of active methylene compounds with various alkylsilyl peroxides has been developed. The reaction has a broad substrate scope and our mechanistic...

scholarly journals A Convenient Method for the Introduction of 1,3-Dithiolan-2-yl Group into Active Methylene Compounds

1978 ◽  
Vol 51 (2) ◽  
pp. 665-666 ◽  
Author(s):  
Shigeo Tanimoto ◽  
Yasuo Matsumura ◽  
Toyonari Sugimoto ◽  
Masaya Okano
Keyword(s):  
Convenient Method ◽  
Active Methylene Compounds ◽  
Active Methylene
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