Activator-induced quencher-detachment-based turn-on probe with a cationic substrate moiety for acetylcholinestera

2021 ◽  
Author(s):  
Masahiro Oe ◽  
Koji Miki ◽  
Akito Masuda ◽  
Kohei Nogita ◽  
Kouichi Ohe
Keyword(s):  
Fluorescence Probe ◽  
Living Cells ◽  
Choline Ester ◽  
Turn On ◽  
Ester Moiety ◽  
Hydrolysis Of

We report a choline ester-grafted turn-on fluorescence probe to detect acetylcholinesterase (AChE) in living cells. AChE-mediated hydrolysis of the choline ester moiety producing carboxylate initiates the activation of Cy5 fluorophore...

A naked-eye visible and turn-on fluorescence probe for Fe3+ and its bioimaging application in living cells

2016 ◽  
Vol 237 ◽  
pp. 501-508 ◽  
Author(s):  
Yaming Liu ◽  
Jinyu Zhang ◽  
Jiaxi Ru ◽  
Xiang Yao ◽  
Yang Yang ◽  
...  
Keyword(s):  
Fluorescence Probe ◽  
Living Cells ◽  
Naked Eye ◽  
Turn On

A Turn‐On Fluorescence Probe for Rapid Detection of Hypochlorite in Living Cells and in Vitro

2019 ◽  
Vol 4 (27) ◽  
pp. 8021-8025 ◽  
Author(s):  
Ya Xie ◽  
Lijia Haung ◽  
Liqiang Yan ◽  
Jianping Li
Keyword(s):  
Rapid Detection ◽  
Fluorescence Probe ◽  
Living Cells ◽  
Turn On

scholarly journals Selective cadmium fluorescence probe based on bis-heterocyclic molecule and its imaging in cells

2021 ◽  
Author(s):  
Masayori Hagimori ◽  
Yasushi Karimine ◽  
Naoko Mizuyama ◽  
Fumiko Hara ◽  
Takeshi Fujino ◽  
...  
Keyword(s):  
Fluorescence Probe ◽  
Living Cells ◽  
Cell Membrane Permeability ◽  
Fluorescence Probes ◽  
Low Molecular Weight ◽  
Biological Applications ◽  
Turn On ◽  
Heterocyclic Molecule ◽  
Heterocyclic Moiety ◽  
In Cells

Abstract Fluorescence probes that selectively image cadmium are useful for detecting and tracking the amount of Cd2+ in cells and tissues. In this study, we designed and synthesized a novel Cd2+ fluorescence probe based on the pyridine-pyrimidine structure, 4-(methylsulfanyl)-6-(pyridin-2-yl)pyrimidin-2-amine (3), as a low-molecular-weight fluorescence probe for Cd2+. Compound 3 could successfully discriminate between Cd2+ and Zn2+ and exhibited a highly selective turn-on response toward Cd2+ over biologically related metal ions. The dissociation constant and detection limit of 5.4 x 10− 6 mol L− 1 and 4.4 × 10− 7 mol L− 1, respectively, were calculated using fluorescence titration experiments. Studies with closely related analogs showed that the bis-heterocyclic moiety of 3 acted as both a coordination site for Cd2+ and a fluorophore. Further, the methylsulfanyl group of compound 3 is essential for achieving selective and sensitive Cd2+ detection. Fluorescence microscopy studies using living cells revealed that the cell membrane permeability of compound 3 is sufficient to detect intracellular Cd2+. These results indicate that novel bis-heterocyclic molecule 3 has considerable potential as a fluorescence probe for Cd2+ in biological applications.

Development of a mitochondrial-targeted two-photon fluorescence turn-on probe for formaldehyde and its bio-imaging applications in living cells and tissues

2018 ◽  
Vol 42 (11) ◽  
pp. 8325-8329 ◽  
Author(s):  
An Xu ◽  
Yonghe Tang ◽  
Weiying Lin
Keyword(s):  
Fluorescence Probe ◽  
Living Cells ◽  
Two Photon ◽  
Turn On ◽  
Bio Imaging ◽  
Fluorescence Turn On ◽  
Two Photon Fluorescence ◽  
Photon Fluorescence ◽  
Liver Tissues

The first mitochondrial-targeted two-photon fluorescence probe (MT-FA) for formaldehyde (FA) was engineered for monitoring FA in the mitochondria of living cells and liver tissues in one- and two-photon modes.

scholarly journals A naphthalimide-based turn-on fluorescence probe for peroxynitrite detection and imaging in living cells

RSC Advances ◽  
2020 ◽  
Vol 10 (63) ◽  
pp. 38281-38286
Author(s):  
Xiling Liu ◽  
Fangyuan Gu ◽  
Xinyi Zhou ◽  
Wei Zhou ◽  
Shuping Zhang ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Hepg2 Cells ◽  
Fluorescence Probe ◽  
Living Cells ◽  
Selective Detection ◽  
C Elegans ◽  
Turn On

A novel fluorescent probe HCA-OH was designed for selective detection of peroxynitrite and imaging in HepG2 cells and C. elegans.

scholarly journals A highly specific and sensitive turn-on fluorescence probe for hypochlorite detection and its bioimaging applications

RSC Advances ◽  
2019 ◽  
Vol 9 (28) ◽  
pp. 15926-15932
Author(s):  
Lei Jin ◽  
Xiaoxue Tan ◽  
Lihui Dai ◽  
Liqiang Sheng ◽  
Qingming Wang
Keyword(s):  
Response Time ◽  
Fluorescence Probe ◽  
Fast Response ◽  
Living Cells ◽  
Sensitive Detection ◽  
Fast Response Time ◽  
Turn On

A new probe, EDPC, was designed and synthesized for highly specific and sensitive detection of ClO− with a fast response time in living cells.

A highly sensitive hemicyanine-based fluorescent chemodosimeter for mercury ions in aqueous solution and living cells

RSC Advances ◽  
2015 ◽  
Vol 5 (100) ◽  
pp. 82531-82534 ◽  
Author(s):  
Yu Chen ◽  
Chengyu Yang ◽  
Zhenni Yu ◽  
Bo Chen ◽  
Yifeng Han
Keyword(s):  
Aqueous Solution ◽  
Vinyl Ether ◽  
Living Cells ◽  
Mercury Ions ◽  
Ether Group ◽  
Turn On ◽  
Highly Sensitive ◽  
Fluorescence Turn On ◽  
Fluorescent Chemodosimeter ◽  
Hydrolysis Of

A novel hemicyanine-based fluorescence turn-on chemodosimeter for Hg2+ by mercury triggered hydrolysis of vinyl ether group has been reported.

Nanoparticles self-assembled from multiple interactions: a novel near-infrared fluorescent sensor for the detection of serum albumin in human sera and turn-on live-cell imaging

2016 ◽  
Vol 52 (6) ◽  
pp. 1178-1181 ◽  
Author(s):  
Xiaopeng Fan ◽  
Qingyuan He ◽  
Shiguo Sun ◽  
Hongjuan Li ◽  
Yuxin Pei ◽  
...  
Keyword(s):  
Serum Albumin ◽  
Live Cell Imaging ◽  
Near Infrared ◽  
Cell Imaging ◽  
Fluorescence Probe ◽  
Fluorescent Sensor ◽  
Living Cells ◽  
Turn On ◽  
Human Sera ◽  
Multiple Interactions

A novel pyrene-conjugated squaraine fluorescence probeSQ-Pcan self-assemble into nanoparticles, selectively detect serum albumin, and be used for imaging in living cells.

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