Phosphine-Catalyzed Sequential (2+3)/(2+4) Annulation of γ Vinyl Allenoates: Access to the Synthesis of Chromeno[4,3 b]pyrroles

2021 ◽  
Author(s):  
You Huang ◽  
Xiaohu Li
Keyword(s):  
Cyclization Reaction ◽  
Pyrrole Derivatives ◽  
Stereogenic Centers

A phosphine-catalyzed cascade (2+3)/(2+4) cyclization reaction of γ-vinyl allenoates with aldimine ester has been developed to provide a series of chromeno[4,3-b]pyrrole derivatives, which contain three contiguous stereogenic centers. The method...

Enantioselective construction of dispirotriheterocycles featuring a 4-aminopyrazolone motif through a cascade Michael/cyclization process

2020 ◽  
Vol 56 (73) ◽  
pp. 10690-10693 ◽  
Author(s):  
Shiqiang Wei ◽  
Xiaoze Bao ◽  
Wenyao Wang ◽  
Shah Nawaz ◽  
Qimin Dai ◽  
...  
Keyword(s):  
Michael Addition ◽  
Cyclization Reaction ◽  
Cyclization Process ◽  
Stereogenic Centers

A highly asymmetric approach to multicyclic dispiro [pyrazolone-pyrrolidinethione-oxindole] core structures bearing three contiguous stereogenic centers through a cascade Michael addition/cyclization reaction of 4-isothiocyanato pyrazolones with 3-ylideneoxindoles was developed.

Brønsted Acid Catalyzed Selective Cyclization Reaction: An Efficient and Facile Synthesis of Polysubstituted Imidazole and Pyrrole Derivatives

Synthesis ◽  
2016 ◽  
Vol 49 (03) ◽  
pp. 637-646 ◽  
Author(s):  
Liangce Rong ◽  
Lei Dai ◽  
Ping Shu ◽  
Zhansheng Wang ◽  
Qingyang Li ◽  
...  
Keyword(s):  
Cyclization Reaction ◽  
Bronsted Acid ◽  
Brønsted Acid ◽  
Facile Synthesis ◽  
Pyrrole Derivatives ◽  
Brönsted Acid ◽  
Acid Catalyzed

Diverse Cyclopentenes via Enantioselective Cu-Catalyzed Desymmetrization

2018 ◽  
Author(s):  
Reece Jacques ◽  
Robert D. C. Pullin ◽  
Stephen P. Fletcher
Keyword(s):  
Ring Systems ◽  
Quaternary Centers ◽  
Stereogenic Centers

<div> <div> <div> <p>A highly regio-, diastereo- and enantioselective Cu-catalyzed desymmetrization of diverse meso-bisphosphates with alkyl zirconium nucleophiles has been developed. The reaction allows access to a broad range of functionalized cyclopentenes with up to three contiguous stereogenic centers, including quaternary centers and spirocyclic ring systems.</p></div></div></div>

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