ROS-Responsive Dexamethasone Micelles Normalize the Tumor Microenvironment to Enhance Hypericin in Cancer Photodynamic Therapy

2022 ◽  
Author(s):  
Ruifeng Liang ◽  
Ka Hong Wong ◽  
Yan Yang ◽  
Yourong Duan ◽  
Meiwan Chen
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Vascular System ◽  
Drug Distribution

Efficacy of photodynamic therapy (PDT) for cancer is limited due to the abnormality of tumor microenvironment (TME), such as dysfunctional tumor vascular system leading to restrict the drug distribution in...

Photoactive conjugated polymer/graphdiyne nanocatalyst for CO2 reduce into CO in living cells for hypoxia tumor treatment

2021 ◽  
Author(s):  
Endong Zhang ◽  
Zicheng Zuo ◽  
Wen Yu ◽  
Hao Zhao ◽  
Shengpeng Xia ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Conjugated Polymer ◽  
Tumor Therapy ◽  
Living Cells ◽  
Tumor Treatment ◽  
Treatment Efficiency ◽  
Therapy Strategy ◽  
Co Gas

Carbon monoxide (CO) gas therapy has grown to be an emerging tumor therapy strategy to avoid low treatment efficiency of photodynamic therapy (PDT) caused by the hypoxia tumor microenvironment. However,...

Oxygen-producing proenzyme hydrogels for photodynamic mediated metastasis-inhibited combinational therapy

2021 ◽  
Author(s):  
Jiansheng Liu ◽  
Xueqin Qing ◽  
Qin Zhang ◽  
Ningyue Yu ◽  
Mengbin Ding ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Solid Tumors ◽  
Therapeutic Efficacy ◽  
Tumor Metastasis ◽  
Combinational Therapy ◽  
Hypoxic Tumor

Photodynamic therapy (PDT) has provided a promising approach for treatment of solid tumors, while the therapeutic efficacy is often limited due to hypoxic tumor microenvironment, resulting in tumor metastasis. We...

scholarly journals Foscan-mediated photodynamic therapy for a peritoneal-cancer model: Drug distribution and efficacy studies

1997 ◽  
Vol 73 (2) ◽  
pp. 230-235 ◽  
Author(s):  
Ruth B. Veenhuizen ◽  
Marjan C. Ruevekamp ◽  
Hugo Oppelaar ◽  
Theo J.M. Helmerhorst ◽  
Peter Kenemans ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Drug Distribution ◽  
Cancer Model ◽  
Peritoneal Cancer ◽  
Model Drug ◽  
Efficacy Studies

scholarly journals Photodynamic Therapy and the Biophysics of the Tumor Microenvironment

2020 ◽  
Vol 96 (2) ◽  
pp. 232-259 ◽  
Author(s):  
Aaron J. Sorrin ◽  
Mustafa Kemal Ruhi ◽  
Nathaniel A. Ferlic ◽  
Vida Karimnia ◽  
William J. Polacheck ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Microenvironment

A Near-Infrared Light-Excitable Immunomodulating Nano-photosensitizer for Effective Photoimmunotherapy

2021 ◽  
Author(s):  
Yadan Zheng ◽  
Zhanzhan Zhang ◽  
Qi Liu ◽  
Ying Wang ◽  
Jialei Hao ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Immune Responses ◽  
Near Infrared ◽  
Tumor Ablation ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Therapeutic Efficiency ◽  
Immunosuppressive Tumor Microenvironment

Photodynamic therapy has great potential for tumor ablation and the activation of antitumor immune responses. However, its overall therapeutic efficiency is often limited by the immunosuppressive tumor microenvironment. We developed...

scholarly journals Numerical Investigation of Drug Transport from Blood Vessels to Tumor Tissue Using a Tumor-Vasculature-on-a-Chip

2019 ◽  
Author(s):  
Wei Li ◽  
Hao-Fei Wang ◽  
Zhi-Yong Li ◽  
Tong Wang ◽  
Chun-Xia Zhao
Keyword(s):  
Tumor Microenvironment ◽  
Blood Vessel ◽  
Drug Concentration ◽  
Tumor Size ◽  
Drug Transport ◽  
Tumor Tissue ◽  
Transport Model ◽  
Temporal Structure ◽  
Drug Distribution ◽  
Tumor Vasculature

AbstractThe delivery of adequate concentration of anticancer drugs to tumor site is critical to achieve effective therapeutic treatment, but it is challenging to experimentally observe drug transport and investigate the spatial distribution of the drug in tumor microenvironment. In this study, we investigated the drug transport from a blood vessel to tumor tissue, and explored the effect of tumor size, tumor numbers and positioning on drug concentration distribution using a numerical method in combination with a microfluidic Tumor-Vasculature-on-a-Chip (TVOC) model. The TVOC model is composed of a vessel channel, a tumor channel sandwiched with a porous membrane. A species transport model based on computational fluid dynamics was adapted to investigate drug transport. The numerical simulation was firstly validated using experimental data, and then used to analyse the spatial-temporal structure of the flow, and to investigate the effect of tumor size and positioning on drug transport and drug concentration heterogeneity. We found the drug concentration surrounding the tumor is highly heterogeneous, with the most downstream point the most difficult for drugs to transport and the nearest point to the blood vessel the easiest. Moreover, tumor size and positioning contribute significantly to this drug concentration heterogeneity on tumor surface, which is dramatically augmented in large and downstream-positioned tumors. These studies established the relationship between solid tumor size/positioning and drug concentration heterogeneity in the tumor microenvironment, which could help to understand heterogenous drug distribution in tumor microenvironment.

Double pH-sensitive Nanotheranostics of Polypeptide Nanoparticle-Encapsulated BODIPY with Both NIR Activated Fluorescence and Enhanced Photodynamic Therapy

2021 ◽  
Author(s):  
Huiping Dang ◽  
Quan Cheng ◽  
Youliang Tian ◽  
Changchang Teng ◽  
Kai Xie ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Fluorescence Imaging ◽  
Intelligent Systems ◽  
Ph Sensitive ◽  
Nir Fluorescence

To achieve accurate fluorescence imaging-guided cancer therapy, intelligent systems with specific responsiveness to the tumor microenvironment need to be designed. Here, we have achieved both enhanced NIR fluorescence and photodynamic...

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