scholarly journals Photodynamic Therapy and the Biophysics of the Tumor Microenvironment

2020 ◽  
Vol 96 (2) ◽  
pp. 232-259 ◽  
Author(s):  
Aaron J. Sorrin ◽  
Mustafa Kemal Ruhi ◽  
Nathaniel A. Ferlic ◽  
Vida Karimnia ◽  
William J. Polacheck ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Microenvironment

Photoactive conjugated polymer/graphdiyne nanocatalyst for CO2 reduce into CO in living cells for hypoxia tumor treatment

2021 ◽  
Author(s):  
Endong Zhang ◽  
Zicheng Zuo ◽  
Wen Yu ◽  
Hao Zhao ◽  
Shengpeng Xia ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Conjugated Polymer ◽  
Tumor Therapy ◽  
Living Cells ◽  
Tumor Treatment ◽  
Treatment Efficiency ◽  
Therapy Strategy ◽  
Co Gas

Carbon monoxide (CO) gas therapy has grown to be an emerging tumor therapy strategy to avoid low treatment efficiency of photodynamic therapy (PDT) caused by the hypoxia tumor microenvironment. However,...

Oxygen-producing proenzyme hydrogels for photodynamic mediated metastasis-inhibited combinational therapy

2021 ◽  
Author(s):  
Jiansheng Liu ◽  
Xueqin Qing ◽  
Qin Zhang ◽  
Ningyue Yu ◽  
Mengbin Ding ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Solid Tumors ◽  
Therapeutic Efficacy ◽  
Tumor Metastasis ◽  
Combinational Therapy ◽  
Hypoxic Tumor

Photodynamic therapy (PDT) has provided a promising approach for treatment of solid tumors, while the therapeutic efficacy is often limited due to hypoxic tumor microenvironment, resulting in tumor metastasis. We...

A Near-Infrared Light-Excitable Immunomodulating Nano-photosensitizer for Effective Photoimmunotherapy

2021 ◽  
Author(s):  
Yadan Zheng ◽  
Zhanzhan Zhang ◽  
Qi Liu ◽  
Ying Wang ◽  
Jialei Hao ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Immune Responses ◽  
Near Infrared ◽  
Tumor Ablation ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Therapeutic Efficiency ◽  
Immunosuppressive Tumor Microenvironment

Photodynamic therapy has great potential for tumor ablation and the activation of antitumor immune responses. However, its overall therapeutic efficiency is often limited by the immunosuppressive tumor microenvironment. We developed...

Double pH-sensitive Nanotheranostics of Polypeptide Nanoparticle-Encapsulated BODIPY with Both NIR Activated Fluorescence and Enhanced Photodynamic Therapy

2021 ◽  
Author(s):  
Huiping Dang ◽  
Quan Cheng ◽  
Youliang Tian ◽  
Changchang Teng ◽  
Kai Xie ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Fluorescence Imaging ◽  
Intelligent Systems ◽  
Ph Sensitive ◽  
Nir Fluorescence

To achieve accurate fluorescence imaging-guided cancer therapy, intelligent systems with specific responsiveness to the tumor microenvironment need to be designed. Here, we have achieved both enhanced NIR fluorescence and photodynamic...

Tumor-Microenvironment Activable Smart Nanocarrier System for Photodynamic Therapy of Cancers

2018 ◽  
Vol 45 (2) ◽  
pp. 0207008
Author(s):  
蓝善优 Lan Shanyou ◽  
张达 Zhang Da ◽  
刘小龙 Liu Xiaolong ◽  
曾永毅 Zeng Yongyi
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Microenvironment

Responsive agarose hydrogel incorporated with natural humic acid and MnO2 nanoparticles for effective relief of tumor hypoxia and enhanced photo-induced tumor therapy

2020 ◽  
Vol 8 (1) ◽  
pp. 353-369 ◽  
Author(s):  
Mengmeng Hou ◽  
Weiwei Liu ◽  
Lei Zhang ◽  
Leiyang Zhang ◽  
Zhigang Xu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Humic Acid ◽  
Tumor Microenvironment ◽  
Tumor Therapy ◽  
Tumor Hypoxia ◽  
Therapeutic Outcome ◽  
Severe Hypoxia ◽  
Tumor Penetration ◽  
Mno2 Nanoparticles ◽  
Agarose Hydrogel

In spite of widespread applications of nano-photosensitizers, poor tumor penetration and severe hypoxia in the tumor microenvironment (TME) always result in an undesirable therapeutic outcome of photodynamic therapy (PDT).

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