Tumor-targeted Biomimetic Nanoplatform Precisely Integrate Photodynamic Therapy and Autophagy Inhibiton for Collaborative Treatment of Oral Cancer

2022 ◽  
Author(s):  
Hao Dai ◽  
Han Yan ◽  
Fan Dong ◽  
Ludan Zhang ◽  
Ning Du ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Oral Cancer ◽  
Surgical Resection ◽  
Functional Impairment ◽  
Malignant Tumor

Oral cancer is a common malignant tumor in the maxillofacial regions. Surgical resection is the preferred treatment, but severe functional impairment after surgery forces us to look for noninvasive treatments....

Dysphagia following Various Degrees of Surgical Resection for Oral Cancer

1992 ◽  
Vol 101 (2) ◽  
pp. 138-141 ◽  
Author(s):  
Minoru Hirano ◽  
Hidetaka Matsuoka ◽  
Yasunao Kuroiwa ◽  
Kiminori Sato ◽  
Shinzo Tanaka ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Surgical Resection ◽  
Tongue Cancer ◽  
Tube Feeding ◽  
The Other ◽  
Surgical Removal ◽  
Swallowing Function ◽  
Pharyngeal Wall ◽  
Swallowing Problems ◽  
Nasogastric Tube Feeding

Postoperative swallowing problems were investigated in 20 patients who had undergone various degrees of surgical resection for oral cancer. The swallowing problems were evaluated on the basis of type of food, degree of aspiration, and duration of postoperative nasogastric tube feeding. Two patients with tongue cancer who had had hemiglossectomy without reconstruction ate normal food without aspiration within a week after operation. Eight patients who had undergone two- to three-quarter glossectomy for tongue cancer ate gruel with no or occasional liquid aspiration. Among 4 patients who had had near-total or total glossectomy for tongue cancer, 3 ate thin gruel or liquid with occasional aspiration. The other could not eat orally because of consistent severe aspiration. One patient with mouth floor cancer underwent resection of the mouth floor in combination with hemiglossectomy and she ate gruel without aspiration. Among 5 patients with mouth floor cancer who had had surgical removal accompanied by near-total or total glossectomy, 3 ate gruel with no or occasional liquid aspiration, 1 ate thin gruel with no aspiration, and the other could not eat orally. A diagnosis of T4 lesions, extensive removal of the tongue base, removal of the geniohyoid and mylohyoid muscles, and removal of the lateral pharyngeal wall were significantly related to poor swallowing function.

scholarly journals Long-term results of ERCP- or PTCS-directed photodynamic therapy for unresectable hilar cholangiocarcinoma

2020 ◽  
Author(s):  
Zongyan Li ◽  
Xiaofeng Jiang ◽  
Hua Xiao ◽  
Shaoyi Chen ◽  
Wenfeng Zhu ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Photodynamic Therapy ◽  
Adverse Events ◽  
Survival Time ◽  
Surgical Resection ◽  
Stent Placement ◽  
Median Survival Time ◽  
Hilar Cholangiocarcinoma ◽  
Stent Group

Abstract Background Photodynamic therapy (PDT) can be performed as palliative therapy for cholangiocarcinoma, while there is currently insufficient evidence for the efficacy. The aim of this study was to explore the clinical efficacy and safety of endoscopic retrograde cholangiopancreatography (ERCP)- or percutaneous transhepatic cholangioscopy (PTCS)-directed PDT combined with stent placement for unresectable hilar cholangiocarcinoma. Methods A retrospective analysis was conducted on 62 patients with unresectable hilar cholangiocarcinoma. Thirty patients received PDT using hematoporphyrin combined with biliary stent placement (PDT+stent group), including 22 receiving ERCP-directed PDT and 8 receiving PTCS-directed PDT. Survival time, quality of life, and postoperative adverse events were compared to 32 patients receiving biliary stent placement alone (Stent-only group). Results After 42 months of follow-up, median survival time was significantly longer in the PDT+stent group than the Stent-only group (14.2 vs. 9.8 months, P = 0.003). In the PDT+stent group, the median survival time was longer in the 6 patients with recurrence after surgical resection than the 24 patients without prior surgical resection (20.0 vs. 13.0 months, P = 0.017). The QOL total scores was significantly higher in the PDT+stent group than the Stent-only group at postoperative 6, 9, and 12 months (P<0.05). There was no significant difference in the incidence of postoperative adverse events between the two groups (24 [38.7%] vs. 20 [29.0%], P = 0.239). Conclusion ERCP- or PTCS-directed PDT + stent placement can prolong the survival of patients with unresectable hilar cholangiocarcinoma, especially those with recurrence and improve quality of life without increasing adverse events.

scholarly journals A HER2 selective theranostic agent for surgical resection guidance and photodynamic therapy

2016 ◽  
Vol 15 (10) ◽  
pp. 1227-1238 ◽  
Author(s):  
H. Pye ◽  
M. A. Butt ◽  
H. W. Reinert ◽  
A. Maruani ◽  
J. P. M. Nunes ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Surgical Resection ◽  
Near Infrared ◽  
Fluorescent Imaging ◽  
Fab Fragment ◽  
Theranostic Agent

This work describes production of a HER2 targeting antibody Fab fragment dual conjugated for both near-infrared fluorescent imaging and photodynamic therapy.

scholarly journals Primary Endobronchial Leiomyosarcoma of the Lung: Clinical, Gross and Microscopic Findings of Two Cases

2012 ◽  
Vol 2 ◽  
pp. 35 ◽  
Author(s):  
Hafsa Elouazzani ◽  
Fouad Zouaidia ◽  
Ahmed Jahid ◽  
Zakiya Bernoussi ◽  
Najat Mahassini
Keyword(s):  
Surgical Resection ◽  
Malignant Tumor ◽  
Preoperative Diagnosis ◽  
Histological Study ◽  
Final Diagnosis ◽  
Immunohistochemical Stain ◽  
Microscopic Findings ◽  
Primary Leiomyosarcoma

Primary leiomyosarcoma of the lung is an unusual malignant tumor. Among this entity, the endobronchial form is very rare and the preoperative diagnosis is extremely difficult. We present two different presentations and outcomes of primary endobronchial leiomyosarcoma of the lung. In both cases, the histological study and the immunohistochemical stain, of the surgical resection, provided the final diagnosis. Through those cases we present the diagnostic and therapeutic difficulties encountered.

scholarly journals Lung cancer as a second primary malignant tumor: prognostic values after surgical resection

2008 ◽  
Vol 7 (1) ◽  
pp. 50-53 ◽  
Author(s):  
J. Furak ◽  
I. Trojan ◽  
T. Szoke ◽  
A. Wolfard ◽  
E. Nagy ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Surgical Resection ◽  
Malignant Tumor ◽  
Second Primary ◽  
Primary Malignant Tumor

O1. Case-matched comparison of photodynamic therapy and surgery of early stage oral cancer

Oral Oncology ◽  
2011 ◽  
Vol 47 ◽  
pp. S28
Author(s):  
M.B. Karakullukcu ◽  
M. Copper ◽  
W.M.C. Klop ◽  
I.B. Tan
Keyword(s):  
Photodynamic Therapy ◽  
Oral Cancer ◽  
Early Stage ◽  
Matched Comparison
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