Fluorescence-enhanced covalent organic framework nanosystem for tumor imaging and photothermal therapy

Nanoscale ◽  
2019 ◽  
Vol 11 (21) ◽  
pp. 10429-10438 ◽  
Author(s):  
Yang Liu ◽  
Yapei Zhang ◽  
Xiaomin Li ◽  
Xuefeng Gao ◽  
Xiaoyan Niu ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Tumor Imaging ◽  
Ph Responsive ◽  
Covalent Organic Framework ◽  
Enhanced Imaging ◽  
Organic Framework

Fluorescence-enhanced imaging and photothermal therapy based on pH-responsive covalent organic framework nanoplatform.

Covalent organic framework based nanoagent for enhanced mild-temperature photothermal therapy

2021 ◽  
Author(s):  
Qiaoqiao Sun ◽  
Kun Tang ◽  
Liqun Song ◽  
Yanhua Li ◽  
Wei Pan ◽  
...  
Keyword(s):  
Laser Irradiation ◽  
Photothermal Therapy ◽  
Covalent Organic Framework ◽  
Mild Temperature ◽  
Organic Framework

Photothermal therapy effectively ablate tumor by the hyperthermia (>50 °C), which was caused by laser irradiation. However, the hyperthermia may inevitably diffuse to the surrounding healthy tissues and induce additional...

scholarly journals A covalent organic framework as a nanocarrier for synergistic phototherapy and immunotherapy

2020 ◽  
Vol 8 (25) ◽  
pp. 5451-5459 ◽  
Author(s):  
Ying Zhou ◽  
Sainan Liu ◽  
Chunling Hu ◽  
Lihan Cai ◽  
Maolin Pang
Keyword(s):  
Photodynamic Therapy ◽  
Local Recurrence ◽  
Cancer Treatment ◽  
Photothermal Therapy ◽  
Tumor Metastasis ◽  
Primary Tumors ◽  
Treatment Methods ◽  
Covalent Organic Framework ◽  
Organic Framework

As traditional cancer treatment methods, photodynamic therapy (PDT) and photothermal therapy (PTT) can eliminate primary tumors, but they cannot inhibit extensive tumor metastasis and local recurrence.

Nanoscale Covalent Organic Framework for Combinatorial Antitumor Photodynamic and Photothermal Therapy

ACS Nano ◽  
2019 ◽  
Vol 13 (11) ◽  
pp. 13304-13316 ◽  
Author(s):  
Qun Guan ◽  
Le-Le Zhou ◽  
Yan-An Li ◽  
Wen-Yan Li ◽  
Shumei Wang ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Covalent Organic Framework ◽  
Organic Framework

Template-free synthesis and metalation of hierarchical covalent organic framework spheres for photothermal therapy

2019 ◽  
Vol 55 (95) ◽  
pp. 14315-14318 ◽  
Author(s):  
Yanshu Shi ◽  
Sainan Liu ◽  
Zhixiang Zhang ◽  
Ying Liu ◽  
Maolin Pang
Keyword(s):  
Photothermal Therapy ◽  
Room Temperature ◽  
Covalent Organic Framework ◽  
Template Free ◽  
Organic Framework

Room temperature synthesized hierarchical COF spheres were metalated with Fe3+ and utilized for photothermal therapy.

Covalent organic frameworks as pH responsive signaling scaffolds

2016 ◽  
Vol 52 (74) ◽  
pp. 11088-11091 ◽  
Author(s):  
Yuwei Zhang ◽  
Xiaochen Shen ◽  
Xiao Feng ◽  
Hong Xia ◽  
Ying Mu ◽  
...  
Keyword(s):  
Aqueous Solutions ◽  
Ph Sensor ◽  
Luminescence Properties ◽  
Covalent Organic Frameworks ◽  
Ph Responsive ◽  
High Crystallinity ◽  
Covalent Organic Framework ◽  
Organic Framework

A β-ketoenamine based covalent organic framework possesses high crystallinity, good porosity, stability and luminescence properties. It can serve as the first COF-based fluorescent pH sensor in aqueous solutions.

Integration of a highly monodisperse covalent organic framework photosensitizer with cation exchange synthesized Ag2Se nanoparticles for enhanced phototherapy

2019 ◽  
Vol 55 (62) ◽  
pp. 9164-9167 ◽  
Author(s):  
Chunling Hu ◽  
Lihan Cai ◽  
Sainan Liu ◽  
Maolin Pang
Keyword(s):  
Cation Exchange ◽  
Photothermal Therapy ◽  
Covalent Organic Framework ◽  
Se Nanoparticles ◽  
Organic Framework

COF–Ag2Se nanoparticles were synthesized via a cation exchange approach and utilized for combined photodynamic and photothermal therapy.

A carbon nanomaterial derived from a nanoscale covalent organic framework for photothermal therapy in the NIR-II biowindow

2020 ◽  
Vol 56 (56) ◽  
pp. 7793-7796 ◽  
Author(s):  
Qun Guan ◽  
Le-Le Zhou ◽  
Li-Na Zhou ◽  
Mengdi Li ◽  
Guo-Xin Qin ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Carbon Nanoparticles ◽  
Carbon Nanomaterial ◽  
Covalent Organic Framework ◽  
Highly Efficient ◽  
Organic Framework

A nanoscale carbon nanomaterial was synthesized through pyrolysis of its NCOF precursor, and the obtained carbon nanoparticles (CNPs) can be highly efficient NIR-II photothermal agents for antitumor treatment via PTT.

Tuning the pore structures and photocatalytic properties of a 2D covalent organic framework with multi-branched photoactive moieties

Nanoscale ◽  
2020 ◽  
Vol 12 (30) ◽  
pp. 16136-16142
Author(s):  
Xuan Wang ◽  
Ming-Jie Dong ◽  
Chuan-De Wu
Keyword(s):  
Photocatalytic Properties ◽  
Effective Strategy ◽  
Covalent Organic Framework ◽  
Highly Efficient ◽  
Pore Structures ◽  
Local Connection ◽  
Organic Framework

An effective strategy to incorporate accessible metalloporphyrin photoactive sites into 2D COFs by establishing a 3D local connection for highly efficient photocatalysis was developed.

A Three-Dimensional Tetraphenylethylene-Based Fluorescence Covalent Organic Framework for Molecular Recognition

2020 ◽  
Author(s):  
Junxia Ren ◽  
Yaozu Liu ◽  
Xin Zhu ◽  
Yangyang Pan ◽  
Yujie Wang ◽  
...  
Keyword(s):  
Molecular Recognition ◽  
Fluorescence Probe ◽  
Three Dimensional ◽  
Hazardous Substances ◽  
Covalent Organic Framework ◽  
Highly Sensitive ◽  
Volatile Organic ◽  
Polycyclic Aromatic ◽  
Better Than ◽  
Organic Framework

<p><a></a><a></a><a></a><a></a><a></a><a></a><a></a><a>The development of highly-sensitive recognition of </a><a></a><a></a><a></a><a></a><a>hazardous </a>chemicals, such as volatile organic compounds (VOCs) and polycyclic aromatic hydrocarbons (PAHs), is of significant importance because of their widespread social concerns related to environment and human health. Here, we report a three-dimensional (3D) covalent organic framework (COF, termed JUC-555) bearing tetraphenylethylene (TPE) side chains as an aggregation-induced emission (AIE) fluorescence probe for sensitive molecular recognition.<a></a><a> </a>Due to the rotational restriction of TPE rotors in highly interpenetrated framework after inclusion of dimethylformamide (DMF), JUC-555 shows impressive AIE-based strong fluorescence. Meanwhile, owing to the large pore size (11.4 Å) and suitable intermolecular distance of aligned TPE (7.2 Å) in JUC-555, the obtained material demonstrates an excellent performance in the molecular recognition of hazardous chemicals, e.g., nitroaromatic explosives, PAHs, and even thiophene compounds, via a fluorescent quenching mechanism. The quenching constant (<i>K</i><sub>SV</sub>) is two orders of magnitude better than those of other fluorescence-based porous materials reported to date. This research thus opens 3D functionalized COFs as a promising identification tool for environmentally hazardous substances.</p>

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