A bilayered skin substitute developed using eggshell membrane crosslinked gelatin-chitosan cryogel

2021 ◽  
Author(s):  
Rituparna Saha ◽  
Shivali Patkar ◽  
Drishti Maniar ◽  
Mamatha M Pillai ◽  
Prakriti Tayalia
Keyword(s):  
Eggshell Membrane ◽  
Skin Substitute ◽  
Risk Of Infection ◽  
Immune Rejection ◽  
Skin Substitutes ◽  
Infection Transmission ◽  
Bioengineered Skin ◽  
Cost Risk

Commercially available allografts and xenografts pose problems such as high cost, risk of infection transmission and immune rejection of grafts. Thus, bioengineered skin substitutes fabricated from natural biomaterials or synthetic...

scholarly journals Bioengineered Skin Substitutes: Advances and Future Trends

2021 ◽  
Vol 11 (4) ◽  
pp. 1493
Author(s):  
Shima Tavakoli ◽  
Agnes S. Klar
Keyword(s):  
Three Dimensional ◽  
Skin Substitute ◽  
Skin Damage ◽  
Skin Substitutes ◽  
Composite Grafts ◽  
Alternative Approach ◽  
Life Threatening ◽  
The Common ◽  
Bioengineered Skin ◽  
Large Skin

As the largest organ in the human body, the skin has the function of maintaining balance and protecting from external factors such as bacteria, chemicals, and temperature. If the wound does not heal in time after skin damage, it may cause infection or life-threatening complications. In particular, medical treatment of large skin defects caused by burns or trauma remains challenging. Therefore, human bioengineered skin substitutes represent an alternative approach to treat such injuries. Based on the chemical composition and scaffold material, skin substitutes can be classified into acellular or cellular grafts, as well as natural-based or synthetic skin substitutes. Further, they can be categorized as epidermal, dermal, and composite grafts, based on the skin component they contain. This review presents the common commercially available skin substitutes and their clinical use. Moreover, the choice of an appropriate hydrogel type to prepare cell-laden skin substitutes is discussed. Additionally, we present recent advances in the field of bioengineered human skin substitutes using three-dimensional (3D) bioprinting techniques. Finally, we discuss different skin substitute developments to meet different criteria for optimal wound healing.

Bioengineered skin substitutes for the management of burns: A systematic review

Burns ◽  
2007 ◽  
Vol 33 (8) ◽  
pp. 946-957 ◽  
Author(s):  
Clarabelle Pham ◽  
John Greenwood ◽  
Heather Cleland ◽  
Peter Woodruff ◽  
Guy Maddern
Keyword(s):  
Systematic Review ◽  
Skin Substitutes ◽  
Bioengineered Skin

Surface modification of electrospun PLGA scaffold with collagen for bioengineered skin substitutes

2016 ◽  
Vol 66 ◽  
pp. 130-137 ◽  
Author(s):  
A.R. Sadeghi ◽  
S. Nokhasteh ◽  
A.M. Molavi ◽  
M. Khorsand-Ghayeni ◽  
H. Naderi-Meshkin ◽  
...  
Keyword(s):  
Surface Modification ◽  
Skin Substitutes ◽  
Plga Scaffold ◽  
Bioengineered Skin

scholarly journals RESIKO PENULARAN INFEKSI DI RUANG AUTOPSI DAN PENERAPAN KEWASPADAAN UNIVERSAL

2015 ◽  
Vol 38 (3) ◽  
pp. 228
Author(s):  
Citra Manela
Keyword(s):  
Infectious Disease ◽  
Developing Countries ◽  
Hepatitis B ◽  
Medical Waste ◽  
Protective Equipment ◽  
Risk Of Infection ◽  
Universal Precaution ◽  
Infection Transmission ◽  
Medical Waste Management ◽  
Selection Of

AbstrakPeningkatan resiko penularan infeksi di ruang autopsi semakin meningkat. Hal ini terjadi karena peningkatan jumlah kasus korban meninggal yang terinfeksi penyakit terutama di negara berkembang. Beberapa studi menyatakan terjadinya peningkatan prevalensi HIV, hepatitis B, C, D dan G, tuberkulosis, penyakit Prion, Hantavirus, campak, infeksi bakteri atau HTCV pada pekerja di ruang autopsi. Penerapan kewaspadaan universal, termasuk standar OSHA, pemilihan disinfektan dan pengolahan limbah medis sangat penting diperhatikan untuk mencegah resiko terjadinya penularan infeksi. Tujuan penulisan tinjauan pustaka ini adalah mengetahui risiko penularan infeksi pada pekerja di ruang autopsi dan penerapan kewaspadaan universal. Penulisan ini berdasarkan studi kepustakaan yang terkait dengan dua topik ini. Penerapan kewaspadaan universal sangat diperlukan dalam pencegahan penularan penyakit infeksi pada pekerja di ruang autopsi yaitu meliputi penggunaan alat pelindung diri yang tepat, perilaku, tindakan mencegah infeksi, disinfeksi dan penanganan sampah medis yang sesuai aturan.AbstractThe risk of infection transmissions in autopsy room is increasing. This happens because the increase of the number of cases died affected by infectious disease, especially in developing countries. Several studies found an increase on the prevalence of HIV , Hepatitis B , C , D and G, Tuberculosis , Prion Disease , Hantavirus , Measles , Bacterial Infection or HTCV on workers in autopsy room .The application of universal precaution , including OSHA standards , the selection of disinfectant, medical waste management is very important to prevent the risk of the infection transmission. The aim of this review was to explain the risks of infection transmissions on workers in autopsy room and the application of universal precaution. Literatures on these two topics were evaluated. Application of universal precautions are very necessary in the prevention of transmission of infectious disease in workers in the autopsy room which includes the use of appropriate personal protective equipment, behaviors, actions to prevent infection, disinfection and treatment of medical waste according to the rules.

scholarly journals Development of a Novel Pre-Vascularized Three-Dimensional Skin Substitute Using Blood Plasma Gel

2018 ◽  
Vol 27 (10) ◽  
pp. 1535-1547 ◽  
Author(s):  
Niann-Tzyy Dai ◽  
Wen-Shyan Huang ◽  
Fang-Wei Chang ◽  
Lin-Gwei Wei ◽  
Tai-Chun Huang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Human Plasma ◽  
Three Dimensional ◽  
Skin Substitute ◽  
Strength Analysis ◽  
Full Thickness ◽  
Skin Substitutes ◽  
Full Thickness Skin ◽  
Post Surgery ◽  
Thickness Skin

Skin substitutes with existing vascularization are in great demand for the repair of full-thickness skin defects. In the present study, we hypothesized that a pre-vascularized skin substitute can potentially promote wound healing. Novel three-dimensional (3D) skin substitutes were prepared by seeding a mixture of human endothelial progenitor cells (EPCs) and fibroblasts into a human plasma/calcium chloride formed gel scaffold, and seeding keratinocytes onto the surface of the plasma gel. The capacity of the EPCs to differentiate into a vascular-like tubular structure was evaluated using immunohistochemistry analysis and WST-8 assay. Experimental studies in mouse full-thickness skin wound models showed that the pre-vascularized gel scaffold significantly accelerated wound healing 7 days after surgery, and resembled normal skin structures after 14 days post-surgery. Histological analysis revealed that pre-vascularized gel scaffolds were well integrated in the host skin, resulting in the vascularization of both the epidermis and dermis in the wound area. Moreover, mechanical strength analysis demonstrated that the healed wound following the implantation of the pre-vascularized gel scaffolds exhibited good tensile strength. Taken together, this novel pre-vascularized human plasma gel scaffold has great potential in skin tissue engineering.

Comparison of Skin Substitutes for Acute and Chronic Wound Management

2021 ◽  
Vol 35 (03) ◽  
pp. 171-180
Author(s):  
Caroline Bay ◽  
Zachary Chizmar ◽  
Edward M. Reece ◽  
Jessie Z. Yu ◽  
Julian Winocour ◽  
...  
Keyword(s):  
Chronic Wound ◽  
Relevant Literature ◽  
Wound Management ◽  
Foot Ulcers ◽  
Skin Substitute ◽  
Diabetic Foot Ulcers ◽  
Structural Elements ◽  
Skin Substitutes ◽  
Treatment Alternative ◽  
Chronic Wound Management

AbstractChronic and acute wounds, such as diabetic foot ulcers and burns, respectively, can be difficult to treat, especially when autologous skin transplantations are unavailable. Skin substitutes can be used as a treatment alternative by providing the structural elements and growth factors necessary for reepithelialization and revascularization from a nonautologous source. As of 2020, there are 76 commercially available skin substitute products; this article provides a review of the relevant literature related to the major categories of skin substitutes available.

A Surgical Device to Study the Efficacy of Bioengineered Skin Substitutes in Mice Wound Healing Models

2017 ◽  
Vol 23 (4) ◽  
pp. 237-242 ◽  
Author(s):  
Marc G. Jeschke ◽  
Ali-Reza Sadri ◽  
Cassandra Belo ◽  
Saeid Amini-Nik
Keyword(s):  
Wound Healing ◽  
Skin Substitutes ◽  
Surgical Device ◽  
Bioengineered Skin
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