A Surgical Device to Study the Efficacy of Bioengineered Skin Substitutes in Mice Wound Healing Models

2017 ◽  
Vol 23 (4) ◽  
pp. 237-242 ◽  
Author(s):  
Marc G. Jeschke ◽  
Ali-Reza Sadri ◽  
Cassandra Belo ◽  
Saeid Amini-Nik
Keyword(s):  
Wound Healing ◽  
Skin Substitutes ◽  
Surgical Device ◽  
Bioengineered Skin

scholarly journals Wound-healing Gene Family Expression Differences Between Fetal and Foreskin Cells Used for Bioengineered Skin Substitutes

2008 ◽  
Vol 32 (7) ◽  
pp. 509-518 ◽  
Author(s):  
Nathalie Hirt-Burri ◽  
Corinne Scaletta ◽  
Stefan Gerber ◽  
Dominique P. Pioletti ◽  
Lee Ann Applegate
Keyword(s):  
Wound Healing ◽  
Gene Family ◽  
Skin Substitutes ◽  
Bioengineered Skin

NANOPARTICLES FOR SKIN WOUND HEALING

Nano LIFE ◽  
2013 ◽  
Vol 03 (03) ◽  
pp. 1342004 ◽  
Author(s):  
MELISSA PRZYBOROWSKI ◽  
FRANCOIS BERTHIAUME
Keyword(s):  
Wound Healing ◽  
Bacterial Load ◽  
Skin Wound ◽  
Bioactive Molecules ◽  
Therapeutic Effects ◽  
Skin Substitutes ◽  
Skin Wound Healing ◽  
Design Elements ◽  
Design Options ◽  
Bioengineered Skin

Over the past two decades, there has been a surge in the development of nanoparticle technologies for therapeutic applications. In the area of skin wound healing, silver nanoparticles have been long used as topical antibacterials, but new types of multifunctional nanosystems that can provide more comprehensive therapeutic effects on wounds are being rolled out. The ability to provide a reservoir of bioactive molecules that can be released over time is a feature of many of these systems, which is critically important for nonhealing wounds, where there often is a persistent bacterial load and a chronic lack of growth factors necessary for healing. A great advantage of nanosystems is that by virtue of their extremely small size, they can be easily incorporated into a wide variety of topical treatments that are currently available for use in the clinic. For example, nanoparticles can be easily introduced into decellularized skin products as well as other bioengineered skin substitutes. The design options available for the nanocarriers are very diverse, including encapsulating the drug in the particle's core or presenting it on the outside of the particle, which can also be decorated with a targeting agent, and the ability to change conformation in response to environmental cues (e.g., pH). These various design elements have been optimized differently to treat different types of wounds.

3D Bioprinted Skin Substitutes for Accelerated Wound Healing and Reduced Scar

2021 ◽  
Vol 18 (4) ◽  
pp. 900-914
Author(s):  
Qin Lian ◽  
Tian Jiao ◽  
Tingze Zhao ◽  
Huichao Wang ◽  
Siming Yang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Skin Substitutes

Bioengineered skin substitutes for the management of burns: A systematic review

Burns ◽  
2007 ◽  
Vol 33 (8) ◽  
pp. 946-957 ◽  
Author(s):  
Clarabelle Pham ◽  
John Greenwood ◽  
Heather Cleland ◽  
Peter Woodruff ◽  
Guy Maddern
Keyword(s):  
Systematic Review ◽  
Skin Substitutes ◽  
Bioengineered Skin

Surface modification of electrospun PLGA scaffold with collagen for bioengineered skin substitutes

2016 ◽  
Vol 66 ◽  
pp. 130-137 ◽  
Author(s):  
A.R. Sadeghi ◽  
S. Nokhasteh ◽  
A.M. Molavi ◽  
M. Khorsand-Ghayeni ◽  
H. Naderi-Meshkin ◽  
...  
Keyword(s):  
Surface Modification ◽  
Skin Substitutes ◽  
Plga Scaffold ◽  
Bioengineered Skin

scholarly journals Invasive Techniques in Scar Management: Skin Substitutes

2020 ◽  
pp. 317-323
Author(s):  
F. W. Timmermans ◽  
E. Middelkoop
Keyword(s):  
Wound Healing ◽  
Scar Formation ◽  
Wound Management ◽  
Skin Substitutes ◽  
Current State ◽  
Scar Management ◽  
Scar Quality ◽  
Engineered Skin Substitutes ◽  
Invasive Techniques

AbstractIn the last decades, skin substitutes have emerged as an important innovation in improving scar quality. They can be applied during the initial wound management but also during scar reconstruction procedures. This chapter provides an overview on the development, current state, and future of cell-seeded and tissue-engineered skin substitutes. We will discuss some of the most important varieties of skin substitutes in the context of scar formation and wound healing.

Skin substitutes for acute and chronic wound healing: an updated review

2020 ◽  
Vol 31 (6) ◽  
pp. 639-648 ◽  
Author(s):  
Christina Dai ◽  
Shawn Shih ◽  
Amor Khachemoune
Keyword(s):  
Wound Healing ◽  
Chronic Wound ◽  
Skin Substitutes

scholarly journals Development of a Novel Pre-Vascularized Three-Dimensional Skin Substitute Using Blood Plasma Gel

2018 ◽  
Vol 27 (10) ◽  
pp. 1535-1547 ◽  
Author(s):  
Niann-Tzyy Dai ◽  
Wen-Shyan Huang ◽  
Fang-Wei Chang ◽  
Lin-Gwei Wei ◽  
Tai-Chun Huang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Human Plasma ◽  
Three Dimensional ◽  
Skin Substitute ◽  
Strength Analysis ◽  
Full Thickness ◽  
Skin Substitutes ◽  
Full Thickness Skin ◽  
Post Surgery ◽  
Thickness Skin

Skin substitutes with existing vascularization are in great demand for the repair of full-thickness skin defects. In the present study, we hypothesized that a pre-vascularized skin substitute can potentially promote wound healing. Novel three-dimensional (3D) skin substitutes were prepared by seeding a mixture of human endothelial progenitor cells (EPCs) and fibroblasts into a human plasma/calcium chloride formed gel scaffold, and seeding keratinocytes onto the surface of the plasma gel. The capacity of the EPCs to differentiate into a vascular-like tubular structure was evaluated using immunohistochemistry analysis and WST-8 assay. Experimental studies in mouse full-thickness skin wound models showed that the pre-vascularized gel scaffold significantly accelerated wound healing 7 days after surgery, and resembled normal skin structures after 14 days post-surgery. Histological analysis revealed that pre-vascularized gel scaffolds were well integrated in the host skin, resulting in the vascularization of both the epidermis and dermis in the wound area. Moreover, mechanical strength analysis demonstrated that the healed wound following the implantation of the pre-vascularized gel scaffolds exhibited good tensile strength. Taken together, this novel pre-vascularized human plasma gel scaffold has great potential in skin tissue engineering.

scholarly journals Nanostructured Fibers Containing Natural or Synthetic Bioactive Compounds in Wound Dressing Applications

Materials ◽  
2020 ◽  
Vol 13 (10) ◽  
pp. 2407 ◽  
Author(s):  
Alexa-Maria Croitoru ◽  
Denisa Ficai ◽  
Anton Ficai ◽  
Natalia Mihailescu ◽  
Ecaterina Andronescu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Electrospun Nanofibers ◽  
Natural Compounds ◽  
Electrospinning Process ◽  
Wound Dressings ◽  
Wound Healing Process ◽  
Skin Substitutes ◽  
Bioactive Constituents ◽  
Electrospinning Method

The interest in wound healing characteristics of bioactive constituents and therapeutic agents, especially natural compounds, is increasing because of their therapeutic properties, cost-effectiveness, and few adverse effects. Lately, nanocarriers as a drug delivery system have been actively investigated and applied in medical and therapeutic applications. In recent decades, researchers have investigated the incorporation of natural or synthetic substances into novel bioactive electrospun nanofibrous architectures produced by the electrospinning method for skin substitutes. Therefore, the development of nanotechnology in the area of dressings that could provide higher performance and a synergistic effect for wound healing is needed. Natural compounds with antimicrobial, antibacterial, and anti-inflammatory activity in combination with nanostructured fibers represent a future approach due to the increased wound healing process and regeneration of the lost tissue. This paper presents different approaches in producing electrospun nanofibers, highlighting the electrospinning process used in fabricating innovative wound dressings that are able to release natural and/or synthetic substances in a controlled way, thus enhancing the healing process.

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